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List of works by Sten Orrenius

1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions

scientific article published on January 1996

16 Preparation and characteristics of isolated kidney cells

scientific article published on 01 January 1981

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo

scientific article

2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration

scientific article published on 01 November 1987

2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel mobilizer of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

scientific article published on January 1990

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

scientific article

4th IUBMB conference on 'The Life and Death of the Cell'. Edinburgh 14-17th July 1996.

scientific article published in April 1997

66 Detection and measurement of drug-induced oxygen radical formation

scientific article published on 01 January 1984

A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis

scientific article published on February 1999

A comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes

scientific article

A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria

scientific article published in January 2001

A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis

scientific article published on July 2002

A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells

scientific article published in July 1974

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei

scientific article

ATP stimulates the uptake of S-dinitrophenylglutathione by rat liver plasma membrane vesicles

scientific article published on 01 November 1988

Activation of hepatocyte protein kinase C by redox-cycling quinones

scientific article published on June 1989

Active transport of leukotrienes into rat hepatocytes

scientific article published on 01 January 1983

Adenosine inhibits protein synthesis in isolated rat hepatocytes. Evidence for a lack of involvement of intracellular calcium in the mechanism of inhibition

scientific article published on 01 April 1995

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes

scientific article published on 01 August 1990

All along the watchtower: on the regulation of apoptosis regulators.

scientific article

Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinones

scientific article published on 01 November 1988

Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes

scientific article published on 01 February 1987

Alterations in intracellular calcium compartmentation following inhibition of calcium efflux from isolated hepatocytes ⬇️

scientific article published on 01 October 1984

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes ⬇️

scientific article published on 01 December 1984

Alterations in thiol and calcium-ion homoeostasis during hydroperoxide and drug metabolism in hepatocytes

scientific article published on 01 February 1984

Alterations of surface morphology caused by the metabolism of menadione in mammalian cells are associated with the oxidation of critical sulfhydryl groups in cytoskeletal proteins

scientific article published on 01 September 1988

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death

scientific article published on 19 September 2008

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei

scientific article

Analysis of mitochondrial dysfunction during cell death

scientific article

Analysis of mitochondrial dysfunction during cell death

scientific article published on 01 August 2003

Analysis of mitochondrial dysfunction during cell death

scientific article published on 01 May 2004

Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid

scientific article published on 01 September 1995

Apoptosis and cancer: where we are and where to go …

article by Boris Zhivotovsky & Sten Orrenius published April 2003 in Seminars in Cancer Biology

Apoptosis in human disease: a new skin for the old ceremony?

scientific article

Apoptosis in neuronal cells: role of caspases

scientific article published in July 1998

Apoptosis induced by a human milk protein

scientific article

Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2.

scientific article published on August 1998

Apoptosis--molecular mechanisms and biomedical implications

scientific article published on February 1996

Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease

scientific article

Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo

Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition

scientific article

Autophagy in toxicology: cause or consequence?

scientific article published on 16 October 2012

BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells

scientific article published on December 1996

Biological Reactive Intermediates and Mechanisms of Cell Death ⬇️

scientific article published on January 1, 2001

Biotransformation of bromobenzene to reactive metabolites by isolated hepatocytes

scientific article published on 01 January 1981

Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis

scientific article published on 01 September 1982

Buried alive: a novel approach to cancer treatment

scientific article published on 01 January 2004

Butylated hydroxytoluene prevents cumene hydroperoxide-induced Ca2+ release from liver mitochondria by inhibiting pyridine nucleotide hydrolysis

scientific article published on 01 June 1992

Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death

scientific article published on December 1, 1992

Ca2(+)-mobilizing hormones stimulate Ca2+ efflux from hepatocytes

scientific article

Ca2+ and cell death

scientific article

Ca2+ and endonuclease activation in radiation-induced lymphoid cell death

scientific article published on 01 July 1993

Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells

scientific article published on 01 October 1997

Ca2+ homeostasis and cytotoxicity in isolated hepatocytes: studies with extracellular adenosine 5'-triphosphate

scientific article published on 01 March 1986

Ca2+-activated mechanisms in cell killing

scientific article

Calcineurin and mitochondrial function in glutamate-induced neuronal cell death

scientific article published in October 1996

Calcium Signaling in Apoptosis

Calcium and cell death mechanisms: a perspective from the cell death community

scientific article published on 03 April 2011

Calcium and mitochondria in the regulation of cell death

scientific article published on April 2015

Calcium ions and oxidative cell injury

scientific article published on January 1, 1992

Calcium signaling and cytotoxicity

scientific article

Calcium signalling and the regulation of apoptosis

scientific article published in October 1998

Calcium-Mediated Mechanisms in Chemically Induced Cell Death ⬇️

scientific article published on January 1, 1992

Calcium-activated DNA fragmentation in rat liver nuclei

scientific article published on 01 April 1989

Calcium-activated DNA fragmentation kills immature thymocytes

scientific article published on 01 May 1989

Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock

scientific article published in January 1990

Calcium-dependent cell death. Role of the endonuclease, protein kinase C, and chromatin conformation

scientific article published on November 21, 1992

Carcinogenesis and apoptosis: paradigms and paradoxes

scientific article

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria ⬇️

scientific article published on 08 October 2003

Cardiolipin oxidation sets cytochrome c free

scientific article published in September 2005

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

scientific article

Caspase-2 function in response to DNA damage

scientific article (publication date: 10 June 2005)

Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids

scientific article published on 8 October 2004

Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death

scientific article

Caspases: their intracellular localization and translocation during apoptosis.

scientific article published in July 1999

Cell cycle and cell death in disease: past, present and future

scientific article

Cell death in adult neural stem cells

scientific article published in December 2002

Cell death in human atherosclerotic plaques involves both oncosis and apoptosis

scientific article published in April 1997

Cell death mechanisms and their implications in toxicology

scientific article published on 09 September 2010

Cell death mechanisms: cross-talk and role in disease

scientific article published on 06 March 2010

Cellular defense mechanisms against toxic substances

scientific article

Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes

scientific article published on August 1995

Cellular signaling in thymocyte apoptosis

scientific article published on December 1, 1992

Cellular signalling in programmed cell death (apoptosis).

scientific article published on April 1990

Characteristics of glutathione biosynthesis by freshly isolated rat kidney cells

scientific article published on 01 January 1980

Characteristics of renal glutathione oxidase activity

scientific article published on 01 August 1981

Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration ⬇️

scientific article published on October 1, 1975

Chelation of intracellular zinc triggers apoptosis in mature thymocytes

scientific article published on 01 July 1993

Chromatin condensation during apoptosis requires ATP.

scientific article published on September 1996

Citrate kills tumor cells through activation of apical caspases

scientific article

Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells

scientific article published on May 1999

Clinical perspectives of cell death: where we are and where to go...

scientific article published on April 2009

Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes. Implications for negative selection

scientific article published on 01 September 1994

Comparison between the effects of the microsomal Ca(2+)-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes

scientific article published on July 1991

Constitutive nuclear NF kappa B/rel DNA-binding activity of rat thymocytes is increased by stimuli that promote apoptosis, but not inhibited by pyrrolidine dithiocarbamate

scientific article published on December 1995

Conversion of catalase to the secondary catalase-peroxide complex (compound II) by alpha-methyldopa ⬇️

scientific article published on 01 July 1981

Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress

scientific article published on November 1988

Corrigendum to "Reactive oxygen species generated in different compartments induce cell death, survival, or senescence". [Free Radic. Biol. Med. 2013 Apr; 57:176-187.].

scientific article

Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis

scientific article published on 29 October 2010

Critical role of sulfhydryl group(s) in ATP-dependent Ca2+ sequestration by the plasma membrane fraction from rat liver

scientific article published on 01 October 1983

Current Concepts in Cell Toxicity ⬇️

scientific article published on May 1, 2001

Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes

scientific article published on 01 April 1993

Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity

scientific article published on November 17, 1992

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system

scientific article published on 01 November 1986

Cytochrome P-450-linked activation of 3-hydroxybenzo(a)pyrene ⬇️

scientific article published on August 4, 1975

Cytochrome P-450-product Complexes Produced by Amphetamine Derivatives: A Comparative Study with Isolated Liver Microsomes and Hepatocytes ⬇️

scientific article published on 01 August 1977

Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis

scientific article published in June 1998

Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells

scientific article published in March 1999

Cytochrome c release from mitochondria proceeds by a two-step process

scientific article

Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.

scientific article

Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca2+-dependent mechanisms

scientific article published in May 1989

Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation.

scientific article published in December 1996

Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia

scientific article published on 01 January 1989

Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells

scientific article published on March 1, 1992

DNA damage induces two distinct modes of cell death in ovarian carcinomas

scientific article published on 7 December 2007

Defects in the apoptotic machinery of cancer cells: role in drug resistance

scientific article

Demonstration and partial characterization of glutathione disulfide-stimulated ATPase activity in the plasma membrane fraction from rat hepatocytes

scientific article published on 01 February 1985

Demonstration of nuclear compartmentalization of glutathione in hepatocytes ⬇️

scientific article published on May 15, 1992

Detection of pro-caspase-3 in cytosol and mitochondria of various tissues

scientific article published in July 1998

Determination of apoptosis and necrosis

scientific article published in May 2001

Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system ⬇️

scientific article published on September 10, 1978

Dexamethasone pre-treatment interferes with apoptotic death in glioma cells.

scientific article published in January 2000

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

scientific article published on December 1994

Differential regulation of the mitochondrial and death receptor pathways in neural stem cells

scientific article published on May 2004

Distinct pathways for stimulation of cytochrome c release by etoposide

scientific article published on 01 October 2000

Disulfiram Is a Potent Inhibitor of Proteases of the Caspase Family ⬇️

scientific article published on 01 December 1997

Dithiocarbamate Toxicity toward Thymocytes Involves Their Copper-Catalyzed Conversion to Thiuram Disulfides, Which Oxidize Glutathione in a Redox Cycle without the Release of Reactive Oxygen Species ⬇️

scientific article published on 01 May 1998

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper ⬇️

scientific article published on 01 November 1995

Dithiocarbamates and the redox regulation of cell death

scientific article published on November 1996

Drug Biotransformation and Hepatotoxicity. Studies with Bromobenzene in Isolated Hepatocytes ⬇️

scientific article published on January 1, 1978

Drug metabolism in isolated rat liver cells

scientific article published on January 1, 1975

Drug-stimulated H2O2 formation in hepatocytes. Possible toxicological implications

scientific article published on 01 January 1981

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis ⬇️

scientific article published on September 15, 1997

Early work on apoptosis, an interview with Sten Orrenius

scientific article published in January 2006

Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes ⬇️

scientific article published on December 15, 1979

Effect of phenobarbital and 3,4-benzpyrene treatment of rats on the microsomal binding and hydroxylation of nortriptyline and desmethyl-imipramine: evidence for qualitative changes in cytochrome P-450-ligand interaction following phenobarbital pretr

scientific article published in January 1972

Effects of N-acetyl-L-cysteine on T-cell apoptosis are not mediated by increased cellular glutathione

scientific article published on 01 March 1995

Effects of different cell constituents on metabolic activation and binding of benzo(a)pyrene to purified and nuclear DNA ⬇️

scientific article published on December 14, 1979

Effects of glutathione and chelating agents on copper-mediated DNA oxidation: pro-oxidant and antioxidant properties of glutathione

scientific article published on 01 July 1993

Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes

scientific article published on January 1986

Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells

scientific article published in February 2001

Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver

scientific article published on 01 June 1993

Evaluation of caspase activity in apoptotic cells

scientific article

Evidence for different localization of glutathione oxidase and γ-glutamyltransferase activities during extracellular glutathione metabolism in isolated perfused rat kidney ⬇️

scientific article published on January 18, 1982

Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes

scientific article published on May 1992

Familial Hemophagocytic Lymphohistiocytosis: Too Little Cell Death Can Seriously Damage Your Health ⬇️

scientific article published on June 1, 2001

Fas-triggered phosphatidylserine exposure is modulated by intracellular ATP.

scientific article

Fatty acid hydroxylation in rat kidney cortex microsomes ⬇️

scientific article published on August 30, 1975

Fatty acid inducible cy tochrome P-454 of rat kidney cortex microsomes

scientific article

Fatty acid interaction with the hydroxylating enzyme system of rat liver microsomes

scientific article published on 01 June 1969

Fluorescence study of DNA-binding metabolites of benzo(a)pyrene formed in hepatocytes isolated from 3-methylcholanthrene-treated rats ⬇️

scientific article published on 01 August 1978

Formation and efflux of glutathione disulfide studied in isolated rat hepatocytes

scientific article published on 01 May 1981

Formation and metabolism of a glutathione-S-conjugate in isolated rat liver and kidney cells.

scientific article published in July 1978

Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone)

scientific article published on 01 April 1987

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA ⬇️

scientific article published on November 1, 1976

Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation

scientific article

Formation of DNA-binding products from isolated benzo[a]pyrene metabolites in rat liver nuclei

scientific article published on 01 March 1978

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

scientific article

Further Studies on Lipid-Peroxide Formation in Isolated Hepatocytes ⬇️

scientific article published on November 15, 1975

Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants

scientific article published on June 1994

Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.

scientific article

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

scientific article published in February 1989

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

scientific article published on December 1998

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function ⬇️

scientific article published on October 1, 1995

Glutathione S-conjugates stimulate ATP hydrolysis in the plasma membrane fraction of rat hepatocytes

scientific article published on 01 July 1985

HAMLET, protein folding, and tumor cell death

scientific article

Heat shock proteins: regulators of stress response and apoptosis

scientific article

Hemoprotein quantitation in isolated hepatocytes

scientific article published on January 25, 1979

Host biochemical defense mechanisms against prooxidants

scientific article published on January 1988

Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c.

scientific article published in January 2001

Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli

scientific article

Hydroperoxide-supported cytochrome P-450-linked fatty acid hydroxylation in liver microsomes ⬇️

scientific article published on February 15, 1975

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts ⬇️

scientific article published on January 1, 1998

Increase in cytosolic Ca2+ concentration during t-butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores

scientific article published on 01 March 1984

Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis

scientific article

Induction of Apoptosis and Potentiation of TNF- and Fas-Mediated Apoptosis in U937 Cells by the Xanthogenate Compound D609 ⬇️

scientific article published on August 25, 1997

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells

scientific article published on 01 February 1991

Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients

scientific article published on August 1999

Induction of dna damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes

scientific article published in June 1984

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione

scientific article published on 01 May 1983

Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C

scientific article published on 01 August 1989

Inhibition of binding of benzo(a)pyrene metabolites to nuclear DNA by glutathione and glutathione S-transferase B

scientific article published on 01 May 1980

Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells

scientific article published in August 1997

Injected cytochrome c induces apoptosis

scientific article published on January 1998

Interaction between the metabolism of drugs: pharmacological aspects

scientific article published on 01 March 1968

Interaction of imipramine, desmethylimipramine, nortriptyline and 1-naphthol with microsomal preparations ⬇️

scientific article published on August 1, 1971

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes

scientific article published on 01 February 1990

Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin

scientific article published on 01 May 1994

Intracellular redox changes during apoptosis

scientific article published in January 1996

Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization

scientific article published in October 2010

Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis

scientific article published in July 1994

Involvement of cellular proteolytic machinery in apoptosis

scientific article

Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis

scientific article published on December 1996

Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes

scientific article published on May 1995

Isolated rat hepatocytes as an experimental tool in the study of cell injury. Effect of anoxia

scientific article published on November 1, 1976

Isolation and partial characterization of a protease involved in Fas-induced apoptosis

scientific article published on May 1995

Isolation and use of liver cells

scientific article published on 01 January 1978

Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+

scientific article published on 01 July 1995

Lamin and beta-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis

scientific article

Lipid Peroxidation in Isolated Hepatocytes ⬇️

scientific article published on January 15, 1975

MITCHELL MEDAL LECTURE

scientific article

Mechanism of Dithiocarbamate Inhibition of Apoptosis: Thiol Oxidation by Dithiocarbamate Disulfides Directly Inhibits Processing of the Caspase-3 Proenzyme

scientific article published on 01 June 1997

Mechanism of inhibition of microsomal mixed-function oxidation by the gut-contents inhibitor of the southern armyworm (Prodenia eridania).

scientific article published on September 1971

Mechanisms of calcium-related cell death

scientific article published on 01 January 1996

Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation

scientific article

Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin ⬇️

scientific article published on 01 July 1988

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis ⬇️

scientific article published on 01 December 1984

Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes

scientific article published on February 1, 1979

Metabolic activation and hepatotoxicity. Metabolism of bromobenzene in isolated hypatocytes

scientific article published on May 1978

Metabolic activation and hepatotoxicity. Toxicity of bromobenzene in hepatocytes isolated from phenobarbital-and diethylmaleate-treated rats

scientific article

Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives

scientific article published on 01 September 1977

Metabolism of benzo[a]pyrene-3,6-quinone by isolated hepatocytes ⬇️

scientific article published on September 22, 1980

Metabolism of glutathione and a glutathione conjugate by isolated kidney cells ⬇️

scientific article published on April 25, 1979

Metabolism of hydrogen peroxide in isolated hepatocytes: Relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2 ⬇️

scientific article published on 01 September 1981

Mitochondria as targets for cancer chemotherapy

scientific article published on 03 December 2008

Mitochondria as targets for chemotherapy

scientific article published on April 2009

Mitochondria in cancer cells: what is so special about them?

scientific article published on 04 March 2008

Mitochondria, oxidative stress and cell death

scientific article (publication date: May 2007)

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition

scientific article published in February 2004

Mitochondrial oxidative stress: implications for cell death

scientific article published on January 2007

Mitochondrial regulation of apoptotic cell death

scientific article published on April 2004

Mitochondrial regulation of apoptotic cell death

scientific article

Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF).

scientific article published on May 2010

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

scientific article published on 12 June 2009

Mobilization of the hormone-sensitive calcium pool increases hepatocyte tight junctional permeability in the perfused rat liver

scientific article published on 01 March 1991

Modifications of Ca2+ signaling by inorganic mercury in PC12 cells

scientific article published on 01 December 1993

Modifications of cell signalling in the cytotoxicity of metals

scientific article

Modulation of cellular glutathione and protein thiol status during quinone metabolism

scientific article published on 01 January 1990

Molecular mechanisms of apoptosis induced by cytotoxic chemicals

scientific article

Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei

scientific article

Multiple Proteases Are Involved in Thymocyte Apoptosis

scientific article published on 01 December 1995

Multiple pathways of cytochrome c release from mitochondria in apoptosis

scientific article

NADPH-dependent reductase solubilized from microsomes by peroxidation and its activity

scientific article published on 01 February 1974

NK cell-induced cytotoxicity is dependent on a Ca2+ increase in the target.

scientific article published in June 1990

Neural stem cells and cell death

scientific article published on April 2004

Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.

scientific article published on January 1997

Newer aspects of substrate binding to cytochrome P-450.

scientific article published in January 1973

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

scientific article published on March 1995

Nuclear calcium transport and the role of calcium in apoptosis

scientific article published on October 1994

On the effect of cellular nucleophiles on the binding of metabolites of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene and 9-hydroxybenzo(a)pyrene to nuclear DNA

scientific article published on 01 May 1980

On the relationship between Ca2+ efflux and membrane damage during t-butylhydroperoxide metabolism by liver mitochondria

scientific article published on 01 March 1983

On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes

scientific article published in January 1989

On the role of calcium in chemical toxicity

scientific article published on 01 January 1987

On the role of thiol groups in the inhibition of liver microsomal Ca2+ sequestration by toxic agents

scientific article published in October 1985

On the significance of drug-induced spectral changes in liver microsomes

scientific article published on January 1972

Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli

scientific article

Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes

scientific article published in July 2001

Outer mitochondrial membrane permeabilization: an open-and-shut case? ⬇️

scientific article published on May 1, 2003

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release

scientific article

Oxidation of glutathione by free radical intermediates formed during peroxidase-catalyzed N-demethylation reactions

scientific article published on 01 October 1983

Oxidation of glutathione during hydroperoxide metabolism. A study using isolated hepatocytes and the glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosourea

scientific article published on 01 February 1984

Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing

scientific article published on 4 January 2010

Oxidative stress-induced plasma membrane blebbing and cytoskeletal alterations in normal and cancer cells

scientific article

Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine ⬇️

scientific article published on December 15, 1979

Partial characterization of a glutathione oxidase present in rat kidney plasma membrane fraction ⬇️

scientific article published on July 27, 1979

Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat

scientific article published on 01 January 1983

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression

scientific article published on 01 December 1999

Phosphatidylserine exposure in Fas type I cells is mitochondria-dependent

scientific article published on June 2003

Phosphatidylserine externalization in cardiolipin-deficient cells

scientific article

Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.

scientific article published on 3 February 2005

Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+ ⬇️

scientific article published on May 25, 1984

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells

scientific article

Proceedings: Isolated liver cells: a valuable tool for the study of drug metabolism

scientific article published on August 1, 1975

Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity

scientific article

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

scientific article published in Journal of Biological Chemistry

Protease activation in apoptosis induced by MAL

scientific article

Proteases in Fas-mediated apoptosis

scientific article

Proteases in apoptosis

scientific article

Purines and their roles in apoptosis ⬇️

scientific article published on September 1, 1997

Pyridine-nucleotide oxidation, Ca2+ cycling and membrane damage during tert-butyl hydroperoxide metabolism by rat-liver mitochondria

scientific article published on 01 April 1984

Quantitation of DNA fragmentation using fiberglass filters

scientific article published on 01 November 1989

Quantitation of hemoproteins in rat small intestinal mucosa with identification of mitochondrial cytochrome P-450 ⬇️

scientific article published on March 25, 1980

Quinone toxicity in hepatocytes without oxidative stress.

scientific article

Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives

scientific article

Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells

scientific article published in May 1999

Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells

Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody

scientific article published on 01 June 1996

Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin

scientific article published on 01 November 1989

Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis

scientific article published on 01 April 1990

Reactive oxygen species generated in different compartments induce cell death, survival, or senescence

scientific article

Reactive oxygen species in mitochondria-mediated cell death

scientific article published on January 2007

Recent studies on cytochrome P-450-linked functions in isolated rat liver cells ⬇️

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Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese

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Redox regulation of apoptotic cell death in the immune system

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Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis

scientific article published on 01 January 1995

Regulation and mechanisms of apoptosis in T lymphocytes.

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Regulation of cell death: the calcium-apoptosis link

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Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide

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Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver

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Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

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Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

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Review: nuclear events in apoptosis

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Role of Ca2+ in toxic cell killing

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Role of Cell Death in Toxicology: Does It Matter How Cells Die?

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Role of apoptosis in pancreatic beta-cell death in diabetes

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Role of calcium in toxic and programmed cell death

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Role of cardiolipin in cytochrome c release from mitochondria

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Role of mitochondria in neuronal apoptosis

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Role of mitochondria in toxic cell death

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Role of mitochondria in toxic oxidative stress.

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Role of nucleases in apoptosis

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Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria

scientific article published on December 1988

Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera

scientific article published in September 2005

Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts

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Signal transduction pathways in apoptosis

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Signal transduction pathways to apoptosis

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Signalling and Chromatin Fragmentation in Thymocyte Apoptosis ⬇️

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Signalling mechanisms and oxidative stress in apoptosis

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Solubilization and partial purification of cytochrome P-450 from rat lung microsomes

scientific article published on 01 January 1975

Special issue composed of minireviews written by scientists from Karolinska Institutet to celebrate its 200-year anniversary. Preface

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Spectral studies on drug-cytochrome P-450 interaction in isolated rat liver cells

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Spectral studies on the rapid uptake and subsequent binding of drugs to cytochrome P-450 in isolated rat liver cells

scientific article published in July 1974

Spermine prevents endonuclease activation and apoptosis in thymocytes*1 ⬇️

scientific article published on 01 August 1991

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress

scientific article published on 01 August 1988

Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling ⬇️

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Susceptibility of different subsets of immature thymocytes to apoptosis

scientific article published on 01 May 1997

Sydney Brenner, Robert Horvitz and John Sulston. Winners of the 2002 Nobel Prize in medicine or physiology. Genetic regulation of organ development and programmed cell death

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Targeting hepatoma using nitric oxide donor strategies

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Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression

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The Consequences of Lipid Peroxidation in Isolated Hepatocytes ⬇️

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The Influence of Inducers on Drug-Metabolizing Enzyme Activity and on Formation of Reactive Drug Metabolites in the Liver ⬇️

scientific article published on 01 January 1980

The Inhibition of the Mitochondrial NADH Oxidase by Alprenolol and the Protective Effect of Cytochrome P-450 ⬇️

scientific article published on 01 August 1975

The Possible Role of Cytochrome P-450 in the Liver “First Pass Elimination” of a P-Receptor Blocking Drug ⬇️

scientific article published on September 1, 1974

The Potential Role of Apoptosis in Human Disease

The Role of Calcium in the Regulation of Apoptosis ⬇️

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The Warburg Effect returns to the cancer stage

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The Warburg effect and mitochondrial stability in cancer cells

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The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis

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The cytochrome P-450-containing mono-oxygenase system of rat kidney cortex microsomes.

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The cytoskeleton as a target in quinone toxicity

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The effect of ethanol on drug oxidations in vitro and the significance of ethanol-cytochrome P-450 interaction

scientific article published on June 1973

The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non-lysosomal proteolytic system

scientific article published on 01 December 1986

The future of toxicology--does it matter how cells die?

scientific article published on June 2006

The measurement of lipid peroxidation in isolated hepatocytes

scientific article published on 01 January 1982

The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium

scientific article published on 01 February 1988

The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells

scientific article published on December 1986

The metabolism of benzo(alpha)pyrene in isolated rat liver cells ⬇️

scientific article published on August 1, 1975

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells ⬇️

scientific article published on October 25, 1982

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium

scientific article published on 01 October 1982

The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release

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The most unkindest cut of all: on the multiple roles of mammalian caspases

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The regulation of apoptosis in thymocytes

scientific article published on August 1994

The renal thiol (glutathione) oxidase subcellular localization and properties ⬇️

scientific article published on June 25, 1984

The role of Ca2+ in cell killing

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The role of calcium in apoptosis

scientific article published on 01 February 1998

The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis

scientific article published on 01 December 1999

The role of intracellular oxidants in apoptosis ⬇️

scientific article published on May 24, 1995

The role of lipid peroxidation in the toxicity of foreign compounds to liver cells

scientific article published on 01 March 1983

The role of methionine in glutathione biosynthesis by isolated hepatocytes

scientific article published on August 22, 1977

The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes

scientific article published on 01 August 1986

The significance of drug-induced spectral changes in liver microsomal fraction ⬇️

scientific article published on November 1, 1971

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+

scientific article published on 01 October 1985

Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins

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Thiol modification and cell signalling in chemical toxicity

scientific article published on December 1, 1992

Toxic Injury to Isolated Hepatocytes Is Not Dependent on Extracellular Calcium ⬇️

scientific article published on September 11, 1981

Toxicity of S-pentachlorobutadienyl-L-cysteine studied with isolated rat renal cortical mitochondria

scientific article published in November 1987

Translocation of amino acids and glutathione studied with the perfused kidney and isolated renal cells

scientific article published on 01 March 1980

Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms

scientific article

Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux

scientific article published on October 1, 1992

Tributyltin stimulates apoptosis in rat thymocytes

scientific article published on 01 November 1990

Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production

scientific article published on 01 October 1999

Triggering and modulation of apoptosis by oxidative stress

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Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation ⬇️

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Tumor radiosensitivity and apoptosis

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Two Different Proteases Are Involved in the Proteolysis of Lamin during Apoptosis

scientific article published on 01 April 1997

Two independently regulated Ca2+ entry mechanisms coexist in Jurkat T cells during T cell receptor antigen activation

scientific article published on July 1993

Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes

scientific article published on 01 September 1994

Use of isolated kidney cells for study of drug metabolism ⬇️

scientific article published on March 15, 1979

Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells

scientific article published on 15 November 2002

Xenobiotic metabolism by isolated rat small intestinal cells

scientific article published on October 1, 1979

[Apoptosis required for maintenance of homeostasis: familial hemophagocytic lymphohistiocytosis caused by too little cell death]

scientific article published on 01 March 2000

[Interaction between the metabolism of drugs: biochemical aspects]

scientific article published on 01 March 1968

m-iodobenzylguanidine increases the mitochondrial Ca2+ pool in isolated hepatocytes

scientific article published on 01 November 1992

tert-Butylhydroperoxide-induced toxicity in isolated hepatocytes: contribution of thiol oxidation and lipid peroxidation

scientific article published on 01 September 1986

‘Centennial’ Nobel Conference on apoptosis and human disease

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