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List of works by Martha Sedegah

A Heterologous DNA Prime-Venezuelan Equine Encephalitis Virus Replicon Particle Boost Dengue Vaccine Regimen Affords Complete Protection from Virus Challenge in Cynomolgus Macaques

scientific article

A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates

scientific article

A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexual-stage antigen, Pfs230.

scientific article published in July 2003

A small peptide (CEL-1000) derived from the beta-chain of the human major histocompatibility complex class II molecule induces complete protection against malaria in an antigen-independent manner

scientific article

Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

scientific article published on 6 July 2015

Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults

scientific article (publication date: 2011)

Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component

scientific article (publication date: 2011)

Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation

scientific article published on 17 March 2014

Cellular immune response to DNA and vaccinia prime-boost immunization kills Plasmodium yoelii-infected hepatocytes in vitro

scientific article published on 5 May 2017

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

scientific article published on November 2012

Co-expression of Interleukin-15 Enhances the Protective Immune Responses Induced by Immunization with a Murine Malaria MVA-Based Vaccine Encoding the Circumsporozoite Protein

scientific article published on 27 October 2015

Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

scientific article

Correction: Vaccine Strain-Specificity of Protective HLA-Restricted Class 1 P. falciparum Epitopes

scientific article published on 20 December 2016

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity

scientific article

Decrease in circulating CD25(hi)Foxp3(+) regulatory T cells following vaccination with the candidate malaria vaccine RTS,S.

scientific article published on 18 July 2016

Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

scientific article

Development of replication-deficient adenovirus malaria vaccines

scientific article published on 8 September 2016

Development of whole sporozoite malaria vaccines

scientific article published on 21 June 2016

Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development

scientific article (publication date: 2015)

Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vec

scientific article published on 29 October 2013

Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines

scientific article

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

scientific article

Human adenovirus 5-vectoredPlasmodium falciparumNMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection ⬇️

scientific article published on 04 June 2013

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

scientific article

Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population

scientific article published on 10 February 2020

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

scientific article published in 2013

Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates

scientific article

Immunological responses of neonates and infants to DNA vaccines

scientific article published on January 2006

Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria

scientific article published on February 2016

Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults

scientific article

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

scientific article

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

scientific article published on 22 July 2016

New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model

scientific article

Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8(+)-T-cell populations

scientific article

Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity

scientific article published on 26 February 2009

Profiling the Targets of Protective CD8+ T Cell Responses to Infection

scientific article published on 18 August 2017

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

scientific article

Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine

scientific article

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

scientific article (publication date: 15 April 2002)

Reduced production of RNA transcripts from individual DNA plasmids given in a multivalent DNA vaccine formula

scientific article published on 9 March 2007

Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update

scientific article published on 29 May 2007

Seroprevalence of antibodies against plasmodium falciparum sporozoite antigens as predictive disease transmission markers in an area of Ghana with seasonal malaria transmission

scientific article

Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes

scientific article

Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers

scientific article published in September 2003

T-cell responses against Malaria: Effect of parasite antigen diversity and relevance for vaccine development

scientific article

The Ex Vivo IFN-γ Enzyme-Linked Immunospot (ELISpot) Assay

scientific article published in January 2015

Vaccine Strain-Specificity of Protective HLA-Restricted Class 1 P. falciparum Epitopes

scientific article

Vaxfectin enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses

scientific article published on 30 October 2009

Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines

scientific article published on 2 November 2005

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