List of works - Dieter M Drexler

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).

scientific article published on 7 October 2016

Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS): A Novel Process Flow for Quality Control Screening of Compound Libraries

scientific article published on 22 July 2015

Addressing the need for biomarker liquid chromatography/mass spectrometry assays: A protocol for effective method development for the bioanalysis of endogenous compounds in cerebrospinal fluid ⬇️

scientific article published on August 30, 2013

Advances in mass spectrometry applied to pharmaceutical metabolomics.

scientific article

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion

scientific article published on 01 February 2008

An empirical process for the design of high-throughput screening deck filters.

scientific article published in May 2006

Analysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometry

scientific article published on 15 February 2014

Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension

scientific article

Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

scientific article

Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides

scientific article published on 01 May 2008

Assessing the risk of drug crystallization in vivo

scientific article published on 13 December 2018

Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds

scientific article published on 15 October 2015

Bioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometry

scientific article published on 01 January 2014

Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.

scientific article published on 24 February 2015

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.

scientific article

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

scientific article

Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening

scientific article published on 29 September 2015

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest. ⬇️

scientific article

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

scientific article published on 25 October 2018

Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips.

scientific article

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

scientific article

Ionization sources and mass analyzers in MS imaging.

scientific article published on 29 October 2015

Labware additives identified to be selective monoamine oxidase-B inhibitors

scientific article published on 08 October 2014

Mass spectrometry techniques for qualitative and quantitative analysis of biomarkers

scientific article published on 01 September 2004

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

scientific article

Normalization strategies for metabonomic analysis of urine samples.

scientific article published on 14 January 2009

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

scientific article

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

scientific article published on 9 March 2016

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

scientific article published on 20 April 2016

Screening and characterization of reactive compounds with in vitro peptide-trapping and liquid chromatography/high-resolution accurate mass spectrometry.

scientific article

Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

scientific article published on April 2010

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures

scientific article

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

scientific article published on 18 November 2014

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.

scientific article published on 6 July 2017

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

scientific article published on 28 March 2016

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

scientific article published on 20 April 2016

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development

scientific article published on 3 February 2017

Tissue Analysis By Imaging Ms ⬇️

scientific article published on January 1, 2012

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

scientific article published in August 2012

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.

scientific article

Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs ⬇️

scientific article published on October 29, 2010

List of works by Dieter M Drexler

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).

Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS): A Novel Process Flow for Quality Control Screening of Compound Libraries

Addressing the need for biomarker liquid chromatography/mass spectrometry assays: A protocol for effective method development for the bioanalysis of endogenous compounds in cerebrospinal fluid ⬇️

Advances in mass spectrometry applied to pharmaceutical metabolomics.

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion

An empirical process for the design of high-throughput screening deck filters.

Analysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometry

Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension

Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides

Assessing the risk of drug crystallization in vivo

Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds

Bioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometry

Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest. ⬇️

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Ionization sources and mass analyzers in MS imaging.

Labware additives identified to be selective monoamine oxidase-B inhibitors

Mass spectrometry techniques for qualitative and quantitative analysis of biomarkers

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

Normalization strategies for metabonomic analysis of urine samples.

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

Screening and characterization of reactive compounds with in vitro peptide-trapping and liquid chromatography/high-resolution accurate mass spectrometry.

Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development

Tissue Analysis By Imaging Ms ⬇️

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.

Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs ⬇️