List of works - Sivaramesh Wigneshweraraj

A Rapid Colorimetric Method to Visualize Protein Interactions.

scientific article published on 5 March 2018

A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement

scientific article

A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism.

scientific article published on April 2013

A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation

article

A role for the conserved GAFTGA motif of AAA+ transcription activators in sensing promoter DNA conformation.

scientific article published on 6 November 2006

Activity map of the Escherichia coli RNA polymerase bridge helix

scientific article published on 25 February 2011

Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG.

scientific article

Beta subunit residues 186-433 and 436-445 are commonly used by Esigma54 and Esigma70 RNA polymerase for open promoter complex formation.

scientific article published on June 2002

Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes.

scientific article published on 21 November 2017

Conservation of sigma-core RNA polymerase proximity relationships between the enhancer-independent and enhancer-dependent sigma classes.

scientific article

Construction and functional analyses of a comprehensive sigma54 site-directed mutant library using alanine-cysteine mutagenesis

scientific article

Correlating protein footprinting with mutational analysis in the bacterial transcription factor sigma54 (sigmaN).

scientific article published on February 2002

Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein.

scientific article published on 19 September 2007

Coupling sigma factor conformation to RNA polymerase reorganisation for DNA melting

scientific article published on 31 January 2009

Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies ⬇️

scientific article published on 19 February 2014

Erratum for Switzer et al., “The Adaptive Response to Long-Term Nitrogen Starvation in Escherichia coli Requires the Breakdown of Allantoin”

scientific article published in 2022

Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase.

scientific article published on 18 July 2017

Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein

scientific article published on 9 May 2017

Functionality of purified sigma(N) (sigma(54)) and a NifA-like protein from the hyperthermophile Aquifex aeolicus.

scientific article

Interplay between the beta' clamp and the beta' jaw domains during DNA opening by the bacterial RNA polymerase at sigma54-dependent promoters.

scientific article

Key roles of the downstream mobile jaw of Escherichia coli RNA polymerase in transcription initiation.

scientific article published on 14 November 2012

Low Resolution Structure of the ς54 Transcription Factor Revealed by X-ray Solution Scattering

scientific article published in Journal of Biological Chemistry

Mapping ATP-dependent activation at a sigma54 promoter

scientific article published on 22 August 2006

Mapping sigma 54-RNA polymerase interactions at the -24 consensus promoter element.

scientific article published on 15 May 2003

Mechanochemical ATPases and transcriptional activation.

scientific article

Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor

scientific article published on 04 March 2008

Molecular insights into the control of transcription initiation at the Staphylococcus aureus agr operon.

scientific article published on 25 June 2011

Molecular mechanism of transcription inhibition by phage T7 gp2 protein

scientific article published on 21 September 2011

Multiple roles of the RNA polymerase beta subunit flap domain in sigma 54-dependent transcription

scientific article published on 06 November 2002

Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility.

scientific article

New insights into the adaptive transcriptional response to nitrogen starvation in

scientific article published on 04 December 2018

Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo

scientific article published on 19 November 2013

Nitrogen stress response and stringent response are coupled in Escherichia coli

scientific article published on 20 June 2014

Opening and closing of the bacterial RNA polymerase clamp

scientific article

Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of 70 domain 1.1

scientific article

Phenotypic consequences of RNA polymerase dysregulation in Escherichia coli.

scientific article published on 23 August 2017

Protein-DNA interactions that govern AAA+ activator-dependent bacterial transcription initiation.

scientific article published on 23 October 2007

Regulatory sequences in sigma 54 localise near the start of DNA melting.

scientific article

Reorganisation of an RNA polymerase-promoter DNA complex for DNA melting.

scientific article published on 7 October 2004

Reprint of: inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2.

scientific article

Sensing DNA opening in transcription using quenchable Förster resonance energy transfer.

scientific article

Sensor I threonine of the AAA+ ATPase transcriptional activator PspF is involved in coupling nucleotide triphosphate hydrolysis to the restructuring of sigma 54-RNA polymerase.

scientific article published on 22 January 2007

Sigma54-dependent transcription activator phage shock protein F of Escherichia coli: a fragmentation approach to identify sequences that contribute to self-association

scientific article

Stable DNA opening within open promoter complexes is mediated by the RNA polymerase beta'-jaw domain.

scientific article

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids.

scientific article published on 24 October 2016

Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2

scientific article

Structural insights into the activity of enhancer-binding proteins.

scientific article

Systematic mutational analysis of the LytTR DNA binding domain of Staphylococcus aureus virulence gene transcription factor AgrA.

scientific article published on 28 October 2014

T7 phage factor required for managing RpoS in Escherichia coli.

scientific article

T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site

scientific article

The Agr quorum-sensing system regulates fibronectin binding but not hemolysis in the absence of a functional electron transport chain.

scientific article

The RNA-binding protein Hfq assembles into foci-like structures in nitrogen starved Escherichia coli

scientific article published on 12 June 2020

The Rsb Phosphoregulatory Network Controls Availability of the Primary Sigma Factor in Chlamydia trachomatis and Influences the Kinetics of Growth and Development.

scientific article published on 27 August 2015

The Xp10 Bacteriophage Protein P7 Inhibits Transcription by the Major and Major Variant Forms of the Host RNA Polymerase via a Common Mechanism.

scientific article published on 8 August 2016

The adaptive response to long-term nitrogen starvation in Escherichia coli requires the breakdown of allantoin

scientific article published on 22 June 2020

The prevalence and implications of single nucleotide polymorphisms in genes encoding the RNA polymerase of clinical isolates of Staphylococcus aureus

scientific article published on 17 May 2020

The sabotage of the bacterial transcription machinery by a small bacteriophage protein.

scientific article published on January 2014

The second paradigm for activation of transcription.

scientific article

Transcriptional downregulation of agr expression in Staphylococcus aureus during growth in human serum can be overcome by constitutively active mutant forms of the sensor kinase AgrC.

scientific article published on 18 November 2013

Visualizing the organization and reorganization of transcription complexes for gene expression.

scientific article

What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?

scientific article

Xenogeneic modulation of the ClpCP protease of Bacillus subtilis by a phage-encoded adaptor-like protein

scientific article published on 30 July 2019

List of works by Sivaramesh Wigneshweraraj

A Rapid Colorimetric Method to Visualize Protein Interactions.

A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement

A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism.

A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation

A role for the conserved GAFTGA motif of AAA+ transcription activators in sensing promoter DNA conformation.

Activity map of the Escherichia coli RNA polymerase bridge helix

Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG.

Beta subunit residues 186-433 and 436-445 are commonly used by Esigma54 and Esigma70 RNA polymerase for open promoter complex formation.

Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes.

Conservation of sigma-core RNA polymerase proximity relationships between the enhancer-independent and enhancer-dependent sigma classes.

Construction and functional analyses of a comprehensive sigma54 site-directed mutant library using alanine-cysteine mutagenesis

Correlating protein footprinting with mutational analysis in the bacterial transcription factor sigma54 (sigmaN).

Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein.

Coupling sigma factor conformation to RNA polymerase reorganisation for DNA melting

Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies ⬇️

Erratum for Switzer et al., “The Adaptive Response to Long-Term Nitrogen Starvation in Escherichia coli Requires the Breakdown of Allantoin”

Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase.

Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein

Functionality of purified sigma(N) (sigma(54)) and a NifA-like protein from the hyperthermophile Aquifex aeolicus.

Interplay between the beta' clamp and the beta' jaw domains during DNA opening by the bacterial RNA polymerase at sigma54-dependent promoters.

Key roles of the downstream mobile jaw of Escherichia coli RNA polymerase in transcription initiation.

Low Resolution Structure of the ς54 Transcription Factor Revealed by X-ray Solution Scattering

Mapping ATP-dependent activation at a sigma54 promoter

Mapping sigma 54-RNA polymerase interactions at the -24 consensus promoter element.

Mechanochemical ATPases and transcriptional activation.

Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor

Molecular insights into the control of transcription initiation at the Staphylococcus aureus agr operon.

Molecular mechanism of transcription inhibition by phage T7 gp2 protein

Multiple roles of the RNA polymerase beta subunit flap domain in sigma 54-dependent transcription

Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility.

New insights into the adaptive transcriptional response to nitrogen starvation in

Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo

Nitrogen stress response and stringent response are coupled in Escherichia coli

Opening and closing of the bacterial RNA polymerase clamp

Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of 70 domain 1.1

Phenotypic consequences of RNA polymerase dysregulation in Escherichia coli.

Protein-DNA interactions that govern AAA+ activator-dependent bacterial transcription initiation.

Regulatory sequences in sigma 54 localise near the start of DNA melting.

Reorganisation of an RNA polymerase-promoter DNA complex for DNA melting.

Reprint of: inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2.

Sensing DNA opening in transcription using quenchable Förster resonance energy transfer.

Sensor I threonine of the AAA+ ATPase transcriptional activator PspF is involved in coupling nucleotide triphosphate hydrolysis to the restructuring of sigma 54-RNA polymerase.

Sigma54-dependent transcription activator phage shock protein F of Escherichia coli: a fragmentation approach to identify sequences that contribute to self-association

Stable DNA opening within open promoter complexes is mediated by the RNA polymerase beta'-jaw domain.

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids.

Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2

Structural insights into the activity of enhancer-binding proteins.

Systematic mutational analysis of the LytTR DNA binding domain of Staphylococcus aureus virulence gene transcription factor AgrA.

T7 phage factor required for managing RpoS in Escherichia coli.

T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site

The Agr quorum-sensing system regulates fibronectin binding but not hemolysis in the absence of a functional electron transport chain.

The RNA-binding protein Hfq assembles into foci-like structures in nitrogen starved Escherichia coli

The Rsb Phosphoregulatory Network Controls Availability of the Primary Sigma Factor in Chlamydia trachomatis and Influences the Kinetics of Growth and Development.

The Xp10 Bacteriophage Protein P7 Inhibits Transcription by the Major and Major Variant Forms of the Host RNA Polymerase via a Common Mechanism.

The adaptive response to long-term nitrogen starvation in Escherichia coli requires the breakdown of allantoin

The prevalence and implications of single nucleotide polymorphisms in genes encoding the RNA polymerase of clinical isolates of Staphylococcus aureus

The sabotage of the bacterial transcription machinery by a small bacteriophage protein.

The second paradigm for activation of transcription.

Transcriptional downregulation of agr expression in Staphylococcus aureus during growth in human serum can be overcome by constitutively active mutant forms of the sensor kinase AgrC.

Visualizing the organization and reorganization of transcription complexes for gene expression.

What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?

Xenogeneic modulation of the ClpCP protease of Bacillus subtilis by a phage-encoded adaptor-like protein