Search filters

List of works by Ronald M. Summers

2D view aggregation for lymph node detection using a shallow hierarchy of linear classifiers

article

3D left ventricular extracellular volume fraction by low-radiation dose cardiac CT: assessment of interstitial myocardial fibrosis

scientific article

A Bottom-up Approach for Pancreas Segmentation using Cascaded Superpixels and (Deep) Image Patch Labeling

scientific article published in November 2016

A Machine Learning Algorithm to Estimate Sarcopenia on Abdominal CT

scientific article published on 22 May 2019

A Review of Deep Learning in Medical Imaging: Imaging Traits, Technology Trends, Case Studies With Progress Highlights, and Future Promises

scientific article published in 2021

A Road Map for Translational Research on Artificial Intelligence in Medical Imaging: From the 2018 National Institutes of Health/RSNA/ACR/The Academy Workshop

scientific article published on 28 May 2019

A cross-platform and distributive database system for cumulative tumor measurement

scientific article

A disentangled generative model for disease decomposition in chest X-rays via normal image synthesis

scientific article published on 07 October 2020

A framework of whole heart extracellular volume fraction estimation for low dose cardiac CT images

article

A framework of whole heart extracellular volume fraction estimation for low-dose cardiac CT images

scientific article

A framework to measure myocardial extracellular volume fraction using dual-phase low dose CT images

scientific article published on October 2013

A multi-center milestone study of clinical vertebral CT segmentation

scientific article

A new 2.5D representation for lymph node detection using random sets of deep convolutional neural network observations ⬇️

scientific article published on 01 January 2014

A prostate cancer computer-aided diagnosis system using multimodal magnetic resonance imaging and targeted biopsy labels

article

A variational framework for joint detection and segmentation of ovarian cancer metastases

article

ANATOMICAL VARIABILITY OF ORGANS VIA PRINCIPAL FACTOR ANALYSIS FROM THE CONSTRUCTION OF AN ABDOMINAL PROBABILISTIC ATLAS

scientific article

Abdominal multi-organ CT segmentation using organ correlation graph and prediction-based shape and location priors

article

Abdominal multi-organ segmentation from CT images using conditional shape-location and unsupervised intensity priors.

scientific article

Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: A multireader study

scientific article published on 8 July 2016

Adaptive deformable model for colonic polyp segmentation and measurement on CT colonography

scientific article published in May 2007

An automatic method for renal cortex segmentation on CT images: evaluation on kidney donors

scientific article published on 15 February 2012

Are we at a crossroads or a plateau? Radiomics and machine learning in abdominal oncology imaging

scientific article published on 01 June 2019

Artificial Intelligence in Musculoskeletal Imaging: A Paradigm Shift

scientific article published on 09 August 2019

Artificial Intelligence of COVID-19 Imaging: A Hammer in Search of a Nail

scientific article published on 22 December 2020

Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets

scientific article published on 14 August 2020

Assessing hepatomegaly: automated volumetric analysis of the liver

scientific article published on 22 February 2012

Assessing splenomegaly: automated volumetric analysis of the spleen

scientific article published on 25 March 2013

Assessment of polyp and mass histopathology by intravenous contrast-enhanced CT colonography.

scientific article published in December 2006

Association between visceral adiposity and colorectal polyps on CT colonography

scientific article

Associations among pericolonic fat, visceral fat, and colorectal polyps on CT colonography

scientific article

Atherosclerotic Plaque Burden on Abdominal CT: Automated Assessment With Deep Learning on Noncontrast and Contrast-enhanced Scans

scientific article published on 18 September 2020

Atlas-based Automated Segmentation of Spleen and Liver using Adaptive Enhancement Estimation

scientific article published on 01 January 2009

Atlas-based automated segmentation of spleen and liver using adaptive enhancement estimation

scientific article published on 01 January 2009

Automated Abdominal CT Imaging Biomarkers for Opportunistic Prediction of Future Major Osteoporotic Fractures in Asymptomatic Adults

scientific article published on 11 August 2020

Automated CT biomarkers for opportunistic prediction of future cardiovascular events and mortality in an asymptomatic screening population: a retrospective cohort study

scientific article published on 02 March 2020

Automated Detection, Localization, and Classification of Traumatic Vertebral Body Fractures in the Thoracic and Lumbar Spine at CT.

scientific article

Automated Liver Fat Quantification at Nonenhanced Abdominal CT for Population-based Steatosis Assessment

scientific article published on 17 September 2019

Automated Polyp Detector for CT Colonography: Feasibility Study

article

Automated abnormality classification of chest radiographs using deep convolutional neural networks

scientific article published on 14 May 2020

Automated centerline for computed tomography colonography

scientific article published in November 2003

Automated detection of sclerotic metastases in the thoracolumbar spine at CT.

scientific article published on 28 February 2013

Automated image‐based colon cleansing for laxative‐free CT colonography computer‐aided polyp detection ⬇️

scientific article published on December 1, 2011

Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps

scientific article

Automated noninvasive classification of renal cancer on multiphase CT ⬇️

scientific article published on October 1, 2011

Automated prostate cancer detection using T2-weighted and high-b-value diffusion-weighted magnetic resonance imaging

scientific article

Automated seed placement for colon segmentation in computed tomography colonography

scientific article published on 01 February 2005

Automated segmentation and quantification of aortic calcification at abdominal CT: application of a deep learning-based algorithm to a longitudinal screening cohort

scientific article published on 01 August 2019

Automated segmentation and quantification of liver and spleen from CT images using normalized probabilistic atlases and enhancement estimation

scientific article

Automated segmentation of the thyroid gland on thoracic CT scans by multiatlas label fusion and random forest classification.

scientific article

Automated teniae coli detection and identification on computed tomographic colonography

scientific article published on February 2012

Automatic correction of level set based subvoxel precise centerlines for virtual colonoscopy using the colon outer wall

scientific article published in August 2007

Automatic magnetic resonance prostate segmentation by deep learning with holistically nested networks

scientific article

Automatic multi-resolution shape modeling of multi-organ structures

scientific article

Automatic segmentation and measurement of pleural effusions on CT.

scientific article

Biomedical Imaging Research Opportunities Workshop II: Report and Recommendations

article

Biopsy-guided learning with deep convolutional neural networks for Prostate Cancer detection on multiparametric MRI

article

Build 4-dimensional myocardial model for dynamic CT images

article

CAD of colon cancer on CT colonography cases without cathartic bowel preparation

scientific article published on January 2008

COMPUTER AIDED EVALUATION OF PLEURAL EFFUSION USING CHEST CT IMAGES.

scientific article

COVID-19-CT-CXR: A Freely Accessible and Weakly Labeled Chest X-Ray and CT Image Collection on COVID-19 From Biomedical Literature

scientific article published on 04 November 2020

COVID-19-CT-CXR: a freely accessible and weakly labeled chest X-ray and CT image collection on COVID-19 from biomedical literature

scientific article published on 11 June 2020

CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension

scientific article published on January 2008

CT colonography computer-aided polyp detection: Effect on radiologist observers of polyp identification by CAD on both the supine and prone scans

scientific article

CT colonography with computer-aided detection as a second reader: observer performance study

scientific article

CT colonography with computer-aided detection: automated recognition of ileocecal valve to reduce number of false-positive detections

scientific article published in October 2004

CT colonography with computer-aided polyp detection: volume and attenuation thresholds to reduce false-positive findings owing to the ileocecal valve

scientific article published on 27 September 2006

CT thermometry for cone-beam CT guided ablation

article

CT virtual bronchoscopy of the central airways in patients with Wegener's granulomatosis.

scientific article published in January 2002

Can computer-aided diagnosis assist in the identification of prostate cancer on prostate MRI? a multi-center, multi-reader investigation

article

Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging

scientific article

Colonic polyp segmentation in CT colonography-based on fuzzy clustering and deformable models

scientific article published in November 2004

Colonic polyps: complementary role of computer-aided detection in CT colonography

scientific article published in November 2002

Combining Statistical and Geometric Features for Colonic Polyp Detection in CTC Based on Multiple Kernel Learning

scientific article

Comparative Evaluation of Three Software Packages for Liver and Spleen Segmentation and Volumetry

scientific article published on 28 February 2017

Comparative evaluation of super high-resolution CT scan and virtual bronchoscopy for the detection of tracheobronchial malignancies

scientific article published in November 2003

Comparative performance of two polyp detection systems on CT colonography.

scientific article

Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population

scientific article

Computer aided detection of epidural masses on computed tomography scans

scientific article

Computer aided evaluation of ankylosing spondylitis using high-resolution CT

scientific article

Computer aided-diagnosis of prostate cancer on multiparametric MRI: a technical review of current research

scientific article

Computer-Aided Infarction Identification from Cardiac CT Images: A Biomechanical Approach with SVM

article

Computer-aided detection of exophytic renal lesions on non-contrast CT images

scientific article

Computer-aided detection of polyps in a colon phantom: effect of scan orientation, polyp size, collimation, and dose

scientific article published in November 2002

Computer-aided detection of polyps on oral contrast-enhanced CT colonography

scientific article published in January 2005

Computer-aided detection of renal calculi from noncontrast CT images using TV-flow and MSER features

scientific article

Computer-aided diagnosis of pulmonary infections using texture analysis and support vector machine classification

scientific article

Computer-aided diagnosis prior to conventional interpretation of prostate mpMRI: an international multi-reader study.

scientific article published on 12 April 2018

Computer-aided renal cancer quantification and classification from contrast-enhanced CT via histograms of curvature-related features

scientific article published on January 2009

Computer-assisted detection of colonic polyps with CT colonography using neural networks and binary classification trees.

scientific article published in January 2003

Computer-assisted detection of subcutaneous melanomas: feasibility assessment

scientific article published on 01 June 2004

Conspicuity of colorectal polyps at CT colonography: visual assessment, CAD performance, and the important role of polyp height

scientific article

Convolutional Invasion and Expansion Networks for Tumor Growth Prediction

scientific article published in February 2018

Convolutional neural network based deep-learning architecture for prostate cancer detection on multiparametric magnetic resonance images

article

Cortical shell unwrapping for vertebral body abnormality detection on computed tomography

scientific article

Current status of CT colonography

article

Data augmentation using generative adversarial networks (CycleGAN) to improve generalizability in CT segmentation tasks

scientific article published on 15 November 2019

Decreased aerobic capacity in children with juvenile dermatomyositis

article

Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning

scientific article published on 11 February 2016

Deep Learning Lends a Hand to Pediatric Radiology

scientific article published on 01 April 2018

Deep learning in medical imaging and radiation therapy

article

Deep learning-based muscle segmentation and quantification at abdominal CT: application to a longitudinal adult screening cohort for sarcopenia assessment

scientific article published on 24 June 2019

DeepLesion: automated mining of large-scale lesion annotations and universal lesion detection with deep learning

scientific article published on 20 July 2018

DeepPap: Deep Convolutional Networks for Cervical Cell Classification

scientific article published on 19 May 2017

Detection and diagnosis of colitis on computed tomography using deep convolutional neural networks

scientific article published on 08 June 2017

Detection of prostate cancer in multiparametric MRI using random forest with instance weighting

scientific article published on April 2017

Detection of vertebral body fractures based on cortical shell unwrapping

scientific article published on 01 January 2012

Discriminative ensemble learning for few-shot chest x-ray diagnosis

scientific article published on 19 November 2020

Distributed human intelligence for colonic polyp classification in computer-aided detection for CT colonography

scientific article published on 24 January 2012

Dose reduction in CT: the time is now.

scientific article

EMPLOYING TOPOGRAPHICAL HEIGHT MAP IN COLONIC POLYP MEASUREMENT AND FALSE POSITIVE REDUCTION

scientific article published on January 2009

Effect of computer-aided detection for CT colonography in a multireader, multicase trial

scientific article

Efficient Hilbert transform-based alternative to Tofts physiological models for representing MRI dynamic contrast-enhanced images in computer-aided diagnosis of prostate cancer

article

Erratum: Prostate cancer detection from multi-institution multiparametric MRIs using deep convolutional neural networks system (Erratum)

scientific article published on 01 July 2019

Evaluation of computer-aided detection and diagnosis systems

scientific article

Evaluation of computer-aided detection devices: consensus is developing

scientific article published on 01 April 2012

FEM-based 3-D tumor growth prediction for kidney tumor

scientific article

Feasibility of simultaneous computed tomographic colonography and fully automated bone mineral densitometry in a single examination

scientific article

Feasibility of using the marginal blood vessels as reference landmarks for CT colonography

scientific article

Fully automated CT imaging biomarkers of bone, muscle, and fat: correcting for the effect of intravenous contrast

scientific article published on 18 September 2020

Fully automated prostate whole gland and central gland segmentation on MRI using holistically nested networks with short connections

scientific article published on 01 April 2019

Fully automated segmentation and quantification of visceral and subcutaneous fat at abdominal CT: application to a longitudinal adult screening cohort

scientific article published on 28 March 2018

Gaussian process inference for estimating pharmacokinetic parameters of dynamic contrast-enhanced MR images

scientific article published on 01 January 2012

Guest Editorial Deep Learning in Medical Imaging: Overview and Future Promise of an Exciting New Technique

scientific article

Holistic classification of CT attenuation patterns for interstitial lung diseases via deep convolutional neural networks.

scientific article published on 6 June 2016

Holistic segmentation of the lung in cine MRI.

scientific article published in October 2017

Hybrid segmentation of colon filled with air and opacified fluid for CT colonography

scientific article published in March 2006

Improved classifier for computer-aided polyp detection in CT colonography by nonlinear dimensionality reduction

scientific article published on April 2008

Improved computer-aided detection of small polyps in CT colonography using interpolation for curvature estimation.

scientific article

Improving Computer-Aided Detection Using Convolutional Neural Networks and Random View Aggregation. ⬇️

scientific article published on 28 September 2015

Improving Polyp Detection Algorithms for CT Colonography: Pareto Front Approach

scientific article

Improving the accuracy of CTC interpretation: computer-aided detection

scientific article

Interpretability of anatomical variability analysis of abdominal organs via clusterization of decomposition modes

scientific article published on January 2008

Interreader Variability of Prostate Imaging Reporting and Data System Version 2 in Detecting and Assessing Prostate Cancer Lesions at Prostate MRI

scientific article published on 27 March 2019

Kidney tumor growth prediction by coupling reaction-diffusion and biomechanical model

scientific article

Linear measurement of polyps in CT colonography using level sets on 3D surfaces

scientific article

Liver Steatosis Categorization on Contrast-Enhanced CT Using a Fully-Automated Deep Learning Volumetric Segmentation Tool: Evaluation in 1,204 Heathy Adults Using Unenhanced CT as Reference Standard

scientific article published on 16 September 2020

Lytic metastases in thoracolumbar spine: computer-aided detection at CT--preliminary study

scientific article published on March 2007

Machine learning and radiology ⬇️

scientific article published on February 23, 2012

Manifold diffusion for exophytic kidney lesion detection on non-contrast CT images

article

Matching 3-D prone and supine CT colonography scans using graphs

scientific article

Mediastinal lymph node detection and station mapping on chest CT using spatial priors and random forest

scientific article published on July 2016

Medical Image Data and Datasets in the Era of Machine Learning-Whitepaper from the 2016 C-MIMI Meeting Dataset Session

scientific article

Mesenteric vasculature-guided small bowel segmentation on 3-D CT.

scientific article

Mixed spine metastasis detection through positron emission tomography/computed tomography synthesis and multiclassifier

scientific article published on April 2017

Multi-organ Segmentation from Multi-phase Abdominal CT via 4D Graphs Using Enhancement, Shape and Location Optimization ⬇️

scientific article published on 01 January 2010

Multi-organ segmentation in abdominal CT images

scientific article published on January 2012

Multicenter Multireader Evaluation of an Artificial Intelligence-Based Attention Mapping System for the Detection of Prostate Cancer With Multiparametric MRI

scientific article published on 05 August 2020

Multimodal image driven patient specific tumor growth modeling

scientific article published on 01 January 2013

Multiple neural network classification scheme for detection of colonic polyps in CT colonography data sets

scientific article

Myocardial strain estimation from CT: towards computer-aided diagnosis on infarction identification

article

NegBio: a high-performance tool for negation and uncertainty detection in radiology reports.

scientific article

Neopterin and quinolinic acid are surrogate measures of disease activity in the juvenile idiopathic inflammatory myopathies.

scientific article published in October 2002

Nomograms for Automated Body Composition Analysis: A Crucial Step for Routine Clinical Implementation

scientific article published on 24 November 2020

Normalized distance along the colon centerline: a method for correlating polyp location on CT colonography and optical colonoscopy

scientific article

Novel thoracic imaging augments diagnosis of bronchial obstruction.

scientific article

On the Interpretability of Artificial Intelligence in Radiology: Challenges and Opportunities

scientific article published on 27 May 2020

Open-Source Radiation Exposure Extraction Engine (RE3) with Patient-Specific Outlier Detection

scientific article published on 7 December 2015

Opportunistic Osteoporosis Screening at Routine Abdominal and Thoracic CT: Normative L1 Trabecular Attenuation Values in More than 20 000 Adults

scientific article published on 26 March 2019

Opportunistic Screening for Metabolic Syndrome in Asymptomatic Adults Utilizing Fully Automated Abdominal CT-based Biomarkers

scientific article published on 29 June 2020

Optimizing area under the ROC curve using semi-supervised learning

scientific article

Optimizing computer-aided colonic polyp detection for CT colonography by evolving the Pareto fronta.

scientific article published on January 2009

Oral contrast adherence to polyps on CT colonography

scientific article published in January 2006

Pancreatic Tumor Growth Prediction With Elastic-Growth Decomposition, Image-Derived Motion, and FDM-FEM Coupling

scientific article

Pancreatic Tumor Growth Prediction with Multiplicative Growth and Image-Derived Motion

scientific article published on January 2015

Patient specific tumor growth prediction using multimodal images

scientific article published on 20 February 2014

Performance of a previously validated CT colonography computer-aided detection system in a new patient population

scientific article published in July 2008

Point-guided modeling and segmentation of myocardium for low dose cardiac CT images

scientific article

Polyp size measurement at CT colonography: what do we know and what do we need to know?

scientific article

Polyps: linear and volumetric measurement at CT colonography

scientific article published on December 2006

Population-based opportunistic osteoporosis screening: Validation of a fully automated CT tool for assessing longitudinal BMD changes

scientific article published on 28 November 2018

Predicting polyp location on optical colonoscopy from CT colonography by minimal-energy curve modeling of the colonoscope path

scientific article

Preparing Medical Imaging Data for Machine Learning

scientific article published on 18 February 2020

Progress in Fully Automated Abdominal CT Interpretation

scientific article published on 21 April 2016

Prostate cancer detection from multi-institution multiparametric MRIs using deep convolutional neural networks

scientific article published on 01 October 2018

Pulmonary artery segmentation and quantification in sickle cell associated pulmonary hypertension

article

Quality assessment for CT colonography: validation of automated measurement of colonic distention and residual fluid

scientific article published in December 2007

Quality assurance and training procedures for computer-aided detection and diagnosis systems in clinical use

scientific article

RENAL TUMOR QUANTIFICATION AND CLASSIFICATION IN TRIPLE-PHASE CONTRAST-ENHANCED ABDOMINAL CT.

scientific article

Radiomics to Predict Microvascular Invasion in Hepatocellular Carcinoma: A Promising Biomarker for Tumor Recurrence

scientific article published in 2023

Reduction of false positives on the rectal tube in computer-aided detection for CT colonography

scientific article published in October 2004

Regional infarction identification from cardiac CT images: a computer-aided biomechanical approach

scientific article published on 12 April 2016

Registration of prone and supine CT colonography scans based on correlation optimized warping and canonical correlation analysis

scientific article

Registration of prone and supine CT colonography scans using correlation optimized warping and canonical correlation analysis

scientific article published on December 2009

Renal Tumor Quantification and Classification in Contrast-Enhanced Abdominal CT.

scientific article published on June 2009

Reversible projection technique for colon unfolding

scientific article

Revisiting oral barium sulfate contrast agents

scientific article published on January 2007

Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography ⬇️

scientific article published on April 26, 2011

Road maps for advancement of radiologic computer-aided detection in the 21st century

scientific article published on 01 October 2003

Scale-based scatter correction for computer-aided polyp detection in CT colonography

scientific article published on December 2008

Science to practice: Detection of active colonic hemorrhage with use of helical CT: findings in a swine model.

scientific article

Seeing is believing: video classification for computed tomographic colonography using multiple-instance learning

scientific article

Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension

scientific article

Sequential Monte Carlo tracking for marginal artery segmentation on CT angiography by multiple cue fusion

article

Sequential Monte Carlo tracking of the marginal artery by multiple cue fusion and random forest regression

scientific article

Sharing images

scientific article published on 01 July 2003

Skeletal muscle magnetic resonance biomarkers in GNE myopathy

scientific article published on 20 November 2020

Spatial aggregation of holistically-nested convolutional neural networks for automated pancreas localization and segmentation.

scientific article published in February 2018

Spatio-Temporal Convolutional LSTMs for Tumor Growth Prediction by Learning 4D Longitudinal Patient Data

scientific article published on 25 September 2019

Special Section Guest Editorial: Radiomics and Deep Learning

scientific article published in October 2017

Statistical 4D graphs for multi-organ abdominal segmentation from multiphase CT ⬇️

scientific article published on February 11, 2012

Statistical location model for abdominal organ localization

scientific article published on 01 January 2009

Strategies for improved interpretation of computer-aided detections for CT colonography utilizing distributed human intelligence ⬇️

scientific article published on May 3, 2012

Support vector machines committee classification method for computer-aided polyp detection in CT colonography

scientific article published in April 2005

Technical and Clinical Factors Affecting Success Rate of a Deep Learning Method for Pancreas Segmentation on CT

scientific article published on 16 September 2019

Temporal and multiinstitutional quality assessment of CT colonography

scientific article published on November 2008

Teniae coli-based circumferential localization system for CT colonography: feasibility study.

scientific article published on May 2007

Texture analysis in radiology: Does the emperor have no clothes?

scientific article published on 21 October 2016

The Evolving Status of Radiomics

scientific article published on 04 February 2020

The elephant in the room: bowel preparation for CT colonography

scientific article published on July 2009

The future of digital health with federated learning

scientific article published on 14 September 2020

Tracheal and central bronchial aerodynamics using virtual bronchoscopy and computational fluid dynamics

scientific article published on 01 August 2004

Tumor burden analysis on computed tomography by automated liver and tumor segmentation

scientific article published on 07 August 2012

Tumor growth prediction with hyperelastic biomechanical model, physiological data fusion, and nonlinear optimization

scientific article published on 01 January 2014

Tumor growth prediction with reaction-diffusion and hyperelastic biomechanical model by physiological data fusion

scientific article

Tumor response assessment using volumetric doubling time: better than RECIST?

scientific article published on 01 August 2014

Tumor sensitive matching flow: A variational method to detecting and segmenting perihepatic and perisplenic ovarian cancer metastases on contrast-enhanced abdominal CT.

scientific article

Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies

article

Validation of the Dominant Sequence Paradigm and Role of Dynamic Contrast-enhanced Imaging in PI-RADS Version 2.

scientific article published on 19 July 2017

Vertebral Body Compression Fractures and Bone Density: Automated Detection and Classification on CT Images

scientific article published on 16 March 2017

Virtual Contrast for Coronary Vessels Based on Level Set Generated Subvoxel Accurate Centerlines ⬇️

scientific article published on September 3, 2006

Virtual bronchoscopy for evaluation of airway disease

scientific article

Virtual bronchoscopy for evaluation of malignant tumors of the thorax

scientific article published in May 2002

Virtual colonoscopy

Visceral fat quantification in asymptomatic adults using abdominal CT: is it predictive of future cardiac events?

scientific article

Visual phrase learning and its application in computed tomographic colonography

article

Wavelet method for CT colonography computer-aided polyp detection

scientific article published on August 2008

Paulina is supported by:

About Paulina

Help