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Authors whose works are in public domain in at least one jurisdiction

List of works by Namandjé N. Bumpus

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pr

scientific article published on September 6, 2011

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

scientific article published on 14 February 2020

A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarate

scientific article

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

scientific article published on 12 December 2013

A targeted proteomics approach for profiling murine cytochrome P450 expression

scientific article published on 04 March 2014

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women ⬇️

scientific article published on July 11, 2012

Antiretroviral drug concentrations in brain tissue of adult decedents

scientific article published on 17 July 2020

Biotransformation and bioactivation reactions - 2018 literature highlights

scientific article published on 01 May 2019

Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism

scientific article published on 23 January 2012

CYP3A5 genotype impacts maraviroc concentrations in healthy volunteers

scientific article

Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid ⬇️

scientific article published on November 19, 2012

Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

scientific article published in 2022

Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study

scientific article

Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction

scientific article

Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc ⬇️

scientific article published on August 24, 2012

Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz ⬇️

scientific article published on September 13, 2012

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.

scientific article

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067.

scientific article published on 11 April 2018

Dissimilarities in the metabolism of antiretroviral drugs used in HIV pre-exposure prophylaxis in colon and vagina tissues ⬇️

scientific article published on August 18, 2013

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

scientific article published on 22 January 2016

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

scientific article

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

scientific article published on 02 July 2019

Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes ⬇️

scientific article published on September 19, 2011

Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1

scientific article published on 15 November 2018

Genetic Variation of the Kinases that Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells

scientific article published on 17 February 2018

Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir

scientific article published on 10 January 2019

HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention

scientific article

Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison ⬇️

scientific article published on 05 August 2013

In silico approach to accelerate the development of mass spectrometry-based proteomics methods for detection of viral proteins: Application to COVID-19

scientific article (preprint)

Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity

scientific article published on 11 July 2008

MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema

scientific article published on 23 July 2018

MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments

scientific article

Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications

scientific article published on 04 December 2007

Metabolism of Long-Acting Rilpivirine Following Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076)

scientific article published on 15 November 2020

Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms

scientific article published on 30 April 2004

Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms

scientific article published on 12 April 2006

Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

scientific article published on 24 September 2021

Pharmacogenomics of Antiretroviral Drug Metabolism and Transport

scientific article published on 22 September 2020

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial

article

Probing ligand structure-activity relationships in pregnane X receptor (PXR): efavirenz and 8-hydroxyefavirenz exhibit divergence in activation.

scientific article published on 11 February 2018

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

scientific article published on 20 October 2021

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate

scientific article

Response to "clinical relevance of CYP3A5 genotype on maraviroc exposures".

scientific article published on May 2015

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

scientific article

Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6.

scientific article published on 10 November 2016

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

scientific article

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization

scientific article

Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following In Vivo Dosing Correlate with Their Safety Profiles in Humans

scientific article published on 23 April 2020

Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz

scientific article published on 4 September 2014

Tenofovir Plasma Concentration from Preexposure Prophylaxis at the Time of Potential HIV Exposure: a Population Pharmacokinetic Modeling and Simulation Study Involving Serodiscordant Couples in East Africa

scientific article published on 25 July 2019

The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation

scientific article

Too many senior white academics still resist recognizing racism

scientific article published on 01 July 2020

Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men

scientific article published on 01 November 2019

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

scientific article published on 27 February 2020

Undisclosed Antiretroviral Drug Use in a Multinational Clinical Trial (HIV Prevention Trials Network 052) ⬇️

scientific article published on November 15, 2013

Utility of Different Adherence Measures for PrEP: Patterns and Incremental Value

scientific article

Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice ⬇️

scientific article published on 08 October 2013

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