List of works - Andrea Armirotti

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

scientific article published on 14 July 2015

3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

scientific article published on 14 May 2014

5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1.

scientific article

A New Drug Delivery System Based on Tauroursodeoxycholic Acid and PEDOT

scientific article published on 15 January 2019

A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.

scientific article

A Swath Label-Free Proteomics insight into the Faah Mouse Liver

scientific article published in Scientific Reports

A new SWATH ion library for mouse adult hippocampal neural stem cells.

scientific article

Achievements and perspectives of top-down proteomics.

scientific article published on October 2010

Activity-Based Probe for N-Acylethanolamine Acid Amidase

scientific article

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling.

scientific article published on 10 February 2017

Author Correction: Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.

scientific article published on 24 May 2018

Bcl-2 Phosphorylation by p38 MAPK

scientific article published in Journal of Biological Chemistry

Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.

scientific article published on 13 November 2014

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

scientific article published on 16 July 2019

Biochemically Controlled Release of Dexamethasone Covalently Bound to PEDOT

scientific article published on 25 June 2018

Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI.

scientific article published in October 2017

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

scientific article published on 19 December 2017

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease

scientific article

Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

scientific article published on 30 March 2020

Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hy

scientific article

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

scientific article published on 08 December 2020

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

scientific article published in 2021

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

scientific article

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells.

scientific article published on 21 August 2007

Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.

scientific article

Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

scientific article

Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine

scientific article

Electrospray ionization ion trap multiple-stage mass spectrometric fragmentation pathways of leucine and isoleucine: an ab initio computational study

scientific article published on 01 January 2007

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study

scientific article published on 01 January 2019

Endogenous N-acyl taurines regulate skin wound healing

scientific article published on 13 July 2016

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

scientific article

GADD34 is a modulator of autophagy during starvation

scientific article published on 25 September 2020

Gender specific decrease of a set of circulating N-acylphosphatidyl ethanolamines (NAPEs) in the plasma of Parkinson's disease patients

scientific article published on 03 May 2019

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

scientific article published on 17 July 2015

Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

scientific article published on 12 March 2016

Graphene Oxide Nanosheets Disrupt Lipid Composition, Ca(2+) Homeostasis, and Synaptic Transmission in Primary Cortical Neurons.

scientific article published on 30 June 2016

Graphene Oxide Upregulates the Homeostatic Functions of Primary Astrocytes and Modulates Astrocyte-to-Neuron Communication

scientific article published on 15 August 2018

Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders

scientific article published on 20 October 2015

How to discriminate between leucine and isoleucine by low energy ESI-TRAP MSn

scientific article published on 28 September 2006

Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses.

scientific article

In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes.

scientific article

Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics

scientific article published on 8 February 2016

Isobaric Labeling Proteomics Allows a High-Throughput Investigation of Protein Corona Orientation

scientific article published on 07 December 2020

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.

scientific article

Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

scientific article (publication date: June 2015)

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

scientific article published on 26 March 2020

Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase.

scientific article

Matrix-assisted laser desorption/ionization mass spectrometry of taxanes.

scientific article published in January 2005

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.

scientific article published on 10 March 2015

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

scientific article published on 20 October 2020

Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose.

scientific article published on 4 April 2003

Patch clamp-assisted single neuron lipidomics.

scientific article

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions ⬇️

scientific article published on 07 March 2012

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons

scientific article published on May 2015

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

scientific article published on 10 May 2018

Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.

scientific article

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies

scientific article published on 23 December 2015

Purification and HPLC-MS analysis of a naturally processed HCMV-derived peptide isolated from the HEK-293T/HLA-E+/Ul40+ cell transfectants and presented at the cell surface in the context of HLA-E.

scientific article published on 21 February 2007

Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS.

scientific article published on 8 March 2015

Role of oleoylethanolamide as a feeding regulator in goldfish.

scientific article

Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia.

scientific article

Searching for a therapy of creatine transporter deficiency: some effects of creatine ethyl ester in brain slices in vitro.

scientific article

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

scientific article published on 12 July 2016

Self-Adhesive and Antioxidant Poly(vinylpyrrolidone)/Alginate-Based Bilayer Films Loaded with <i>Malva sylvestris</i> Extracts as Potential Skin Dressings

scientific article published on 18 May 2022

Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies

scientific article published on 10 August 2017

Structural characterization of the As/Sb reductase LmACR2 from Leishmania major

scientific article

Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain

scientific article

Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.

scientific article published on 10 March 2017

Synthesis of Highly Fluorescent Copper Clusters Using Living Polymer Chains as Combined Reducing Agents and Ligands

scientific article published on 09 November 2015

Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors

scientific article published on 08 January 2014

Temsirolimus in patients with renal cancer on hemodialysis.

scientific article

The N-acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis.

scientific article published on 17 October 2017

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.

scientific article published on 8 February 2018

Top-down proteomics with a quadrupole time-of-flight mass spectrometer and collision-induced dissociation.

scientific article

Trastuzumab quantification in serum: a new, rapid, robust ELISA assay based on a mimetic peptide that specifically recognizes trastuzumab.

scientific article

beta-amyloid is different in normal aging and in Alzheimer disease.

scientific article published on 15 August 2005

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine

scientific article

List of works by Andrea Armirotti

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1.

A New Drug Delivery System Based on Tauroursodeoxycholic Acid and PEDOT

A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.

A Swath Label-Free Proteomics insight into the Faah Mouse Liver

A new SWATH ion library for mouse adult hippocampal neural stem cells.

Achievements and perspectives of top-down proteomics.

Activity-Based Probe for N-Acylethanolamine Acid Amidase

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling.

Author Correction: Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.

Bcl-2 Phosphorylation by p38 MAPK

Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

Biochemically Controlled Release of Dexamethasone Covalently Bound to PEDOT

Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI.

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease

Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hy

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells.

Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.

Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine

Electrospray ionization ion trap multiple-stage mass spectrometric fragmentation pathways of leucine and isoleucine: an ab initio computational study

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study

Endogenous N-acyl taurines regulate skin wound healing

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

GADD34 is a modulator of autophagy during starvation

Gender specific decrease of a set of circulating N-acylphosphatidyl ethanolamines (NAPEs) in the plasma of Parkinson's disease patients

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

Graphene Oxide Nanosheets Disrupt Lipid Composition, Ca(2+) Homeostasis, and Synaptic Transmission in Primary Cortical Neurons.

Graphene Oxide Upregulates the Homeostatic Functions of Primary Astrocytes and Modulates Astrocyte-to-Neuron Communication

Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders

How to discriminate between leucine and isoleucine by low energy ESI-TRAP MSn

Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses.

In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes.

Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics

Isobaric Labeling Proteomics Allows a High-Throughput Investigation of Protein Corona Orientation

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.

Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase.

Matrix-assisted laser desorption/ionization mass spectrometry of taxanes.

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose.

Patch clamp-assisted single neuron lipidomics.

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions ⬇️

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies

Purification and HPLC-MS analysis of a naturally processed HCMV-derived peptide isolated from the HEK-293T/HLA-E+/Ul40+ cell transfectants and presented at the cell surface in the context of HLA-E.

Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS.

Role of oleoylethanolamide as a feeding regulator in goldfish.

Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia.

Searching for a therapy of creatine transporter deficiency: some effects of creatine ethyl ester in brain slices in vitro.

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

Self-Adhesive and Antioxidant Poly(vinylpyrrolidone)/Alginate-Based Bilayer Films Loaded with <i>Malva sylvestris</i> Extracts as Potential Skin Dressings

Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies

Structural characterization of the As/Sb reductase LmACR2 from Leishmania major

Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain

Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.

Synthesis of Highly Fluorescent Copper Clusters Using Living Polymer Chains as Combined Reducing Agents and Ligands

Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors

Temsirolimus in patients with renal cancer on hemodialysis.

The N-acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis.

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.

Top-down proteomics with a quadrupole time-of-flight mass spectrometer and collision-induced dissociation.

Trastuzumab quantification in serum: a new, rapid, robust ELISA assay based on a mimetic peptide that specifically recognizes trastuzumab.

beta-amyloid is different in normal aging and in Alzheimer disease.

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine