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List of works by Hiroshi Kawashima

Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women.

scientific article published on 21 March 2011

Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.

scientific article published on 27 August 2009

Arachidonate-enriched triglyceride oil does not promote tumor development in a rat medium-term multi-organ carcinogenesis model.

scientific article

Arachidonic acid and cancer risk: a systematic review of observational studies.

scientific article

Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice

scientific article published on 13 April 2015

Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses

scientific article

Arachidonic acid enhances intracellular calcium levels in dentate gyrus, but not CA1, in aged rat.

scientific article published on 6 March 2009

Arachidonic acid improves aged rats' spatial cognition.

scientific article published in March 2005

Arachidonic acid-enriched triacylglycerol improves cognitive function in elderly with low serum levels of arachidonic acid

scientific article published on 13 February 2014

Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in Tg2576 Mice.

scientific article published in August 2015

Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly

scientific article published on 21 December 2015

Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers ⬇️

scientific article published on August 13, 2011

Cloning and sequencing of the ura3 and ura5 genes, and isolation and characterization of uracil auxotrophs of the fungus Mortierella alpina 1S-4.

scientific article

Construction and expression of a mouse-human chimeric antibody against human tumor necrosis factor-alpha

scientific article published on 01 December 1998

Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers

scientific article published on 22 December 2015

Dietary effects of mead acid on N-methyl-N-nitrosourea-induced mammary cancers in female Sprague-Dawley rats

scientific article published on 14 October 2015

Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin A₄ contents in colon, but does not affect severity or prostaglandin E₂ content in murine colitis model.

scientific article published on 10 February 2014

Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model

scientific article published on 16 January 2015

Differential effect of arachidonic acid and docosahexaenoic acid on age-related decreases in hippocampal neurogenesis.

scientific article published on 19 August 2014

Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin D1 production in NC/Tnd mice.

scientific article published on 6 April 2015

Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats.

scientific article published on 7 September 2006

Effect of dietary enrichment with n-3 polyunsaturated fatty acids (PUFA) or n-9 PUFA on arachidonate metabolism in vivo and experimentally induced inflammation in mice.

scientific article published in March 2004

Effect of human plasma-type platelet-activating factor acetylhydrolase in two anaphylactic shock models.

scientific article

Effects of arachidonate-enriched triacylglycerol supplementation on serum fatty acids and platelet aggregation in healthy male subjects with a fish diet

scientific article published on 20 April 2007

Effects of dietary arachidonic acid supplementation on age-related changes in endothelium-dependent vascular responses

scientific article published on 01 February 2007

Effects of oleic, arachidonic and 5,8,11,14-nonadecatetraenoic acids on lipid secretion and ketogenesis in perfused rat liver

scientific article published on 01 January 1991

Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway

scientific article published on 11 November 2010

Epitope mapping of monoclonal antibodies against N-domain of carcinoembryonic antigen

scientific article published on 01 March 1999

Establishment of an overall transformation system for an oil-producing filamentous fungus, Mortierella alpina 1S-4.

scientific article

Fucoidin, a potent inhibitor of L-selectin function, reduces contact hypersensitivity reaction in mice

scientific article published on 01 October 1997

Fungal mycelia as a novel source of eicosapentaenoic acid. Activation of enzyme(s) involved in eicosapentaenoic acid production at low temperature

scientific article published on 01 January 1988

Humanization of a mouse neutralizing monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha)

scientific article published on 01 January 1999

Inhibition of rat liver microsomal desaturases by curcumin and related compounds.

scientific article published in January 1996

Inhibitory effect of curcumin on fatty acid desaturation in Mortierella alpina 1S-4 and rat liver microsomes

scientific article published on 01 July 1992

Inhibitory effects of alkyl gallate and its derivatives on fatty acid desaturation

scientific article published on 01 January 1996

Intake of arachidonic acid-containing lipids in adult humans: dietary surveys and clinical trials

scientific article published on 16 April 2019

Interrelated effects of dihomo-γ-linolenic and arachidonic acids, and sesamin on hepatic fatty acid synthesis and oxidation in rats

scientific article published on 28 February 2012

Long-chain Polyunsaturated Fatty Acid Supplementation Improves Mood in Elderly Japanese Men.

scientific article published on 13 June 2017

Longitudinal Association between -3 Long-Chain Polyunsaturated Fatty Acid Intake and Depressive Symptoms: A Population-Based Cohort Study in Japan

scientific article published on 03 November 2018

Low Doses of Long-chain Polyunsaturated Fatty Acids Affect Cognitive Function in Elderly Japanese Men: A Randomized Controlled Trial

scientific article published on 20 April 2015

Low-dose arachidonic acid intake increases erythrocytes and plasma arachidonic acid in young women.

scientific article published on 26 June 2010

Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice.

scientific article published in January 2016

Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites

scientific article published on 18 November 2015

Mead acid inhibits the growth of KPL-1 human breast cancer cells in vitro and in vivo.

scientific article

Mead acid supplementation does not rescue rats from cataract and retinal degeneration induced by N-methyl-N-nitrosourea

scientific article

Nicardipine and nifedipine inhibit fatty acid desaturases in rat liver microsomes

scientific article published on 01 October 1996

Occurrence of a novel sterol, 24,25-methylenecholest-5-en-3β-ol, inMortierella alpina 1S-4

scientific article published on 01 June 1992

Oral administration of dihomo-gamma-linolenic acid prevents development of atopic dermatitis in NC/Nga mice.

scientific article published on 6 November 2007

Oral supplementation with dihomo-gamma-linolenic acid-enriched oil altered serum fatty acids in healthy men.

scientific article

Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults

scientific article published on 14 March 2012

Preparation of 13C-labeled polyunsaturated fatty acids by an arachidonic acid-producing fungus Mortierella alpina 1S-4

scientific article published on 01 August 1995

Production of 5,8,11-eicosatrienoic acid by a delta5 and delta6 desaturation activity-enhanced mutant derived from a delta12 desaturation activity-defective mutant of Mortierella alpina 1S-4.

scientific article published on 5 October 2002

Production of Polyunsaturated Fatty Acids by Microorganisms ⬇️

scientific article published on January 1, 1992

Purification and characterization of two forms of cytochrome b5 from an arachidonic acid-producing fungus, Mortierella hygrophila

scientific article published on 01 June 1995

Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis

scientific article published on 01 July 1991

Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled study.

scientific article published on 22 December 2011

Synaptic plasticity preserved with arachidonic acid diet in aged rats.

scientific article published in August 2003

Transformation of oil-producing fungus, Mortierella alpina 1S-4, using Zeocin, and application to arachidonic acid production.

scientific article published in December 2005

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