List of works - Pär Nordlund

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery ⬇️

scientific article published on February 27, 2012

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions

scientific article published in PLoS ONE

Arginine 104 Is a Key Catalytic Residue in Leukotriene C4 Synthase

scientific article

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

scientific article

Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome

scientific article published on 27 April 2020

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes

scientific article

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim

scientific article

Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site

scientific article

Crystal structure of a human mitochondrial deoxyribonucleotidase

scientific article

Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition

scientific article

Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes

scientific article

Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus

scientific article

Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues

scientific article

Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization

scientific article published on 23 January 2004

Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data

scientific article (publication date: 18 March 2003)

EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center

scientific article (publication date: 15 November 2002)

Engineering membrane protein overproduction in Escherichia coli

scientific article

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell

scientific article

HF-EPR, Raman, UV/VIS light spectroscopic, and DFT studies of the ribonucleotide reductase R2 tyrosyl radical from Epstein-Barr virus

scientific article

High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris

scientific journal article

High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA

scientific article

In situ proteolysis for protein crystallization and structure determination

scientific article

Molecular and structural basis for redox regulation of beta-actin

scientific article

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

scientific article

Protein production and purification

scientific article

Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II ⬇️

scientific article published on March 17, 2011

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

scientific article

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase ⬇️

scientific article published on March 22, 2013

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1

scientific article

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

scientific article

Structural basis for adenosylcobalamin activation in AdoCbl-dependent ribonucleotide reductases

scientific article

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization ⬇️

scientific article published on February 20, 2011

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases

scientific article

Structural basis for recognition by an in vitro evolved affibody

scientific article

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters ⬇️

scientific article published on April 28, 2013

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

scientific article

Structural studies of tri-functional human GART

scientific article

Structure and function of the Escherichia coli ribonucleotide reductase protein R2

scientific article

Structure of the C-terminal domain of nsp4 from feline coronavirus

scientific article

Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

scientific article

Structures of BIR domains from human NAIP and cIAP2

scientific article

Substrate specificity and oligomerization of human GMP synthetase

scientific article

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site

scientific article

The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor ⬇️

scientific article published on February 21, 2013

The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism

scientific article

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

scientific article

The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins

scientific article

The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass

scientific article

The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity

scientific article

The structure of human collapsin response mediator protein 2, a regulator of axonal growth

scientific article

The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle

scientific article

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.

scientific article

Three-dimensional structure of the free radical protein of ribonucleotide reductase

scientific article

List of works by Pär Nordlund

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery ⬇️

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions

Arginine 104 Is a Key Catalytic Residue in Leukotriene C4 Synthase

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim

Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site

Crystal structure of a human mitochondrial deoxyribonucleotidase

Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition

Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes

Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus

Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues

Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization

Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data

EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center

Engineering membrane protein overproduction in Escherichia coli

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell

HF-EPR, Raman, UV/VIS light spectroscopic, and DFT studies of the ribonucleotide reductase R2 tyrosyl radical from Epstein-Barr virus

High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris

High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA

In situ proteolysis for protein crystallization and structure determination

Molecular and structural basis for redox regulation of beta-actin

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

Protein production and purification

Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II ⬇️

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase ⬇️

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

Structural basis for adenosylcobalamin activation in AdoCbl-dependent ribonucleotide reductases

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization ⬇️

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases

Structural basis for recognition by an in vitro evolved affibody

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters ⬇️

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Structural studies of tri-functional human GART

Structure and function of the Escherichia coli ribonucleotide reductase protein R2

Structure of the C-terminal domain of nsp4 from feline coronavirus

Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

Structures of BIR domains from human NAIP and cIAP2

Substrate specificity and oligomerization of human GMP synthetase

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site

The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor ⬇️

The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins

The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass

The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity

The structure of human collapsin response mediator protein 2, a regulator of axonal growth

The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.

Three-dimensional structure of the free radical protein of ribonucleotide reductase