List of works - Chiye J Aoki

A Distributed Network for Social Cognition Enriched for Oxytocin Receptors

scientific article published on February 2016

A method of combining biocytin tract-tracing with avidin-biotin-peroxidase complex immunocytochemistry for pre-embedding electron microscopic labeling in neonatal tissue ⬇️

scientific article published on June 1, 1998

AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice.

scholarly article

Activation of β-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume.

scientific article published on 16 April 2016

Activity-based anorexia during adolescence disrupts normal development of the CA1 pyramidal cells in the ventral hippocampus of female rats.

scientific article

Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1 ⬇️

scientific article published on November 1, 2014

Adolescence as a Critical Period for Developmental Plasticity

scientific article published in January 2017

Adolescent female C57BL/6 mice with vulnerability to activity-based anorexia exhibit weak inhibitory input onto hippocampal CA1 pyramidal cells.

scientific article published on 21 March 2013

Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor α4 and δ subunits at the plasma membrane of hippocampal CA1 spines

scientific article published on 15 February 2012

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

scientific journal article

Alterations in receptor number, affinity and laminar distribution in cat visual cortex during the critical period ⬇️

scientific article published on January 1, 1984

Anxiety is correlated with running in adolescent female mice undergoing activity-based anorexia

scientific article

C-terminal tail of beta-adrenergic receptors: immunocytochemical localization within astrocytes and their relation to catecholaminergic neurons in N. tractus solitarii and area postrema

scientific article published on January 31, 1992

Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons ⬇️

scientific article published on April 1, 1998

Cerebellar sub-divisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia

scientific article

Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.

scientific article

Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice

scientific article

Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition ⬇️

scientific article published on July 11, 2012

Cholinergic terminals in the cat visual cortex: ultrastructural basis for interaction with glutamate-immunoreactive neurons and other cells

scientific article published on 01 March 1992

Comparison of proteins involved with cyclic AMP metabolism between synaptic membrane and postsynaptic density preparations isolated from canine cerebral cortex and cerebellum.

scientific article published in March 1985

Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

scientific article published on 06 March 2020

Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes

scientific article

Cytoplasmic loop of beta-adrenergic receptors: synaptic and intracellular localization and relation to catecholaminergic neurons in the nuclei of the solitary tracts

scientific article published on 01 July 1989

Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression.

scientific article

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

scientific article published on 29 March 2019

Dendrites of the dorsal and ventral hippocampal CA1 pyramidal neurons of singly housed female rats exhibit lamina-specific growths and retractions during adolescence that are responsive to pair housing

scientific article published on 6 April 2018

Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey.

scientific article published in November 2006

Differential glucose utilization in the parafascicular region during slow-wave sleep, the still-alert state and locomotion.

scientific article published in October 1987

Differential timing for the appearance of neuronal and astrocytic β-adrenergic receptors in the developing rat visual cortex as revealed by light and electron-microscopic immunocytochemistry ⬇️

scientific article published on 01 November 1997

Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses

scientific journal article

Drebrin a knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex.

scientific article published on November 2009

Early life trauma increases threat response of peri-weaning rats, reduction of axo-somatic synapses formed by parvalbumin cells and perineuronal net in the basolateral nucleus of amygdala

scientific article published on 18 October 2018

Effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration of female rats

scientific article published on 04 November 2020

Endogenous GluR1‐containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: An electron microscopic immunocytochemical study ⬇️

scientific article published on December 1, 2010

Enlargement of Axo-Somatic Contacts Formed by GAD-Immunoreactive Axon Terminals onto Layer V Pyramidal Neurons in the Medial Prefrontal Cortex of Adolescent Female Mice Is Associated with Suppression of Food Restriction-Evoked Hyperactivity and Resi

scientific article published on 15 May 2015

Excitatory synapses on dendritic shafts of the caudal basal amygdala exhibit elevated levels of GABAAreceptor α4 subunits following the induction of activity-based anorexia ⬇️

scientific article published on July 30, 2013

Exogenous progesterone exacerbates running response of adolescent female mice to repeated food restriction stress by changing α4-GABAA receptor activity of hippocampal pyramidal cells

scientific article

Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain

scientific journal article

From attachment to independence: Stress hormone control of ecologically relevant emergence of infants' responses to threat.

scientific article published on April 2017

Gain modulation by nicotine in macaque v1.

scientific article

Hearing loss raises excitability in the auditory cortex.

scientific article

Identification of mitochondrial and non-mitochondrial glutaminase within select neurons and glia of rat forebrain by electron microscopic immunocytochemistry ⬇️

scientific article published on April 1, 1991

In vivo blockade of N-methyl-D-aspartate receptors induces rapid trafficking of NR2B subunits away from synapses and out of spines and terminals in adult cortex.

scientific article

In vivo, competitive blockade of N-methyl-D-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex.

scientific article

Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.

scientific article published on August 2000

Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.

scientific article published on 22 February 2012

Making of a Synapse: Recurrent Roles of Drebrin A at Excitatory Synapses Throughout Life.

scientific article

Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons

scientific article

Muscarinic receptor M(2) in cat visual cortex: laminar distribution, relationship to gamma-aminobutyric acidergic neurons, and effect of cingulate lesions.

scientific article

NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals.

scientific article published in February 2003

NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise.

scientific article

Neuropeptide Y in the cerebral cortex and the caudate-putamen nuclei: ultrastructural basis for interactions with GABAergic and non-GABAergic neurons

scientific article published in December 1989

Neuropeptide Y-containing neurons in the rat striatum: ultrastructure and cellular relations with tyrosine hydroxylase- containing terminals and with astrocytes

scientific article published on 01 September 1988

Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse

scientific article published on 24 December 2014

Nitric oxide synthase in the visual cortex of monocular monkeys as revealed by light and electron microscopic immunocytochemistry ⬇️

scientific article published on August 20, 1993

Obituary

scientific article published on 01 February 2000

Pathogenesis of murine encephalitis limited by defective interfering particles. An immunohistochemical study

scientific article published on June 1, 1995

Perikaryal and synaptic localization of alpha 2A-adrenergic receptor-like immunoreactivity.

scientific article

Postnatal changes in the laminar and subcellular distribution of NMDA-R1 subunits in the cat visual cortex as revealed by immuno-electron microscopy

scientific article published on 01 January 1997

Presenilin conditional double knockout mice exhibit decreases in drebrin a at hippocampal CA1 synapses ⬇️

scientific article published on July 20, 2012

Preservation of ultrastructure and antigenicity for EM immunocytochemistry following intracellular recording and labeling of single cortical neurons in brain slices ⬇️

scientific article published on June 1, 1998

Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice.

scientific article published on April 1996

Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty

scientific article published on 11 March 2007

Role of α4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period.

scientific article published on 26 January 2016

SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.

scientific article published on 20 July 2009

Single injection of ketamine during mid-adolescence promotes long-lasting resilience to activity-based anorexia of female mice by increasing food intake and attenuating hyperactivity as well as anxiety-like behavior

scientific article published on 13 August 2018

Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes.

scientific article published on 2 December 2005

Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expression of metallothionein-III (GIF) mRNA in immortalized mouse brain glial cells (VR-2g) ⬇️

scientific article published on May 11, 1998

Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa.

scientific article

The biochemical anatomy of cortical inhibitory synapses

scientific article

The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons

scientific article

Ultrastructural immunolocalization of the alpha 7 nAChR subunit in guinea pig medial prefrontal cortex.

scientific article

Ultrastructural relations between beta-adrenergic receptors and catecholaminergic neurons.

scientific article published in September 1992

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

scientific article

Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia.

scientific article

Voluntary Wheel Running Exercise Evoked by Food-Restriction Stress Exacerbates Weight Loss of Adolescent Female Rats But Also Promotes Resilience by Enhancing GABAergic Inhibition of Pyramidal Neurons in the Dorsal Hippocampus

scientific article published on 01 September 2019

α4βδ-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at exc

scientific article published on 20 February 2017

α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia.

scientific article published on 18 January 2014

⍺4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males.

scientific article published on 20 April 2018

List of works by Chiye J Aoki

A Distributed Network for Social Cognition Enriched for Oxytocin Receptors

A method of combining biocytin tract-tracing with avidin-biotin-peroxidase complex immunocytochemistry for pre-embedding electron microscopic labeling in neonatal tissue ⬇️

AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice.

Activation of β-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume.

Activity-based anorexia during adolescence disrupts normal development of the CA1 pyramidal cells in the ventral hippocampus of female rats.

Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1 ⬇️

Adolescence as a Critical Period for Developmental Plasticity

Adolescent female C57BL/6 mice with vulnerability to activity-based anorexia exhibit weak inhibitory input onto hippocampal CA1 pyramidal cells.

Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor α4 and δ subunits at the plasma membrane of hippocampal CA1 spines

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

Alterations in receptor number, affinity and laminar distribution in cat visual cortex during the critical period ⬇️

Anxiety is correlated with running in adolescent female mice undergoing activity-based anorexia

C-terminal tail of beta-adrenergic receptors: immunocytochemical localization within astrocytes and their relation to catecholaminergic neurons in N. tractus solitarii and area postrema

Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons ⬇️

Cerebellar sub-divisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia

Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.

Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice

Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition ⬇️

Cholinergic terminals in the cat visual cortex: ultrastructural basis for interaction with glutamate-immunoreactive neurons and other cells

Comparison of proteins involved with cyclic AMP metabolism between synaptic membrane and postsynaptic density preparations isolated from canine cerebral cortex and cerebellum.

Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes

Cytoplasmic loop of beta-adrenergic receptors: synaptic and intracellular localization and relation to catecholaminergic neurons in the nuclei of the solitary tracts

Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression.

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

Dendrites of the dorsal and ventral hippocampal CA1 pyramidal neurons of singly housed female rats exhibit lamina-specific growths and retractions during adolescence that are responsive to pair housing

Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey.

Differential glucose utilization in the parafascicular region during slow-wave sleep, the still-alert state and locomotion.

Differential timing for the appearance of neuronal and astrocytic β-adrenergic receptors in the developing rat visual cortex as revealed by light and electron-microscopic immunocytochemistry ⬇️

Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses

Drebrin a knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex.

Early life trauma increases threat response of peri-weaning rats, reduction of axo-somatic synapses formed by parvalbumin cells and perineuronal net in the basolateral nucleus of amygdala

Effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration of female rats

Endogenous GluR1‐containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: An electron microscopic immunocytochemical study ⬇️

Enlargement of Axo-Somatic Contacts Formed by GAD-Immunoreactive Axon Terminals onto Layer V Pyramidal Neurons in the Medial Prefrontal Cortex of Adolescent Female Mice Is Associated with Suppression of Food Restriction-Evoked Hyperactivity and Resi

Excitatory synapses on dendritic shafts of the caudal basal amygdala exhibit elevated levels of GABAAreceptor α4 subunits following the induction of activity-based anorexia ⬇️

Exogenous progesterone exacerbates running response of adolescent female mice to repeated food restriction stress by changing α4-GABAA receptor activity of hippocampal pyramidal cells

Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain

From attachment to independence: Stress hormone control of ecologically relevant emergence of infants' responses to threat.

Gain modulation by nicotine in macaque v1.

Hearing loss raises excitability in the auditory cortex.

Identification of mitochondrial and non-mitochondrial glutaminase within select neurons and glia of rat forebrain by electron microscopic immunocytochemistry ⬇️

In vivo blockade of N-methyl-D-aspartate receptors induces rapid trafficking of NR2B subunits away from synapses and out of spines and terminals in adult cortex.

In vivo, competitive blockade of N-methyl-D-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex.

Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.

Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.

Making of a Synapse: Recurrent Roles of Drebrin A at Excitatory Synapses Throughout Life.

Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons

Muscarinic receptor M(2) in cat visual cortex: laminar distribution, relationship to gamma-aminobutyric acidergic neurons, and effect of cingulate lesions.

NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals.

NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise.

Neuropeptide Y in the cerebral cortex and the caudate-putamen nuclei: ultrastructural basis for interactions with GABAergic and non-GABAergic neurons

Neuropeptide Y-containing neurons in the rat striatum: ultrastructure and cellular relations with tyrosine hydroxylase- containing terminals and with astrocytes

Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse

Nitric oxide synthase in the visual cortex of monocular monkeys as revealed by light and electron microscopic immunocytochemistry ⬇️

Obituary

Pathogenesis of murine encephalitis limited by defective interfering particles. An immunohistochemical study

Perikaryal and synaptic localization of alpha 2A-adrenergic receptor-like immunoreactivity.

Postnatal changes in the laminar and subcellular distribution of NMDA-R1 subunits in the cat visual cortex as revealed by immuno-electron microscopy

Presenilin conditional double knockout mice exhibit decreases in drebrin a at hippocampal CA1 synapses ⬇️

Preservation of ultrastructure and antigenicity for EM immunocytochemistry following intracellular recording and labeling of single cortical neurons in brain slices ⬇️

Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice.

Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty

Role of α4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period.

SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.

Single injection of ketamine during mid-adolescence promotes long-lasting resilience to activity-based anorexia of female mice by increasing food intake and attenuating hyperactivity as well as anxiety-like behavior

Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes.

Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expression of metallothionein-III (GIF) mRNA in immortalized mouse brain glial cells (VR-2g) ⬇️

Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa.

The biochemical anatomy of cortical inhibitory synapses

The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons

Ultrastructural immunolocalization of the alpha 7 nAChR subunit in guinea pig medial prefrontal cortex.

Ultrastructural relations between beta-adrenergic receptors and catecholaminergic neurons.

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia.

Voluntary Wheel Running Exercise Evoked by Food-Restriction Stress Exacerbates Weight Loss of Adolescent Female Rats But Also Promotes Resilience by Enhancing GABAergic Inhibition of Pyramidal Neurons in the Dorsal Hippocampus

α4βδ-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at exc

α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia.

⍺4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males.