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List of works by Denise V Tambourgi

A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice

scientific article

A biotechnological approach to immunotherapy: Antivenom against Crotalus durissus cascavella snake venom produced from biodegradable nanoparticles

scientific article published on 01 October 2018

A natural carrier effect and the generation of specific antibodies to biologically active peptides

scientific article published on 30 March 2006

A new anti-loxoscelic serum produced against recombinant sphingomyelinase D: results of preclinical trials.

scientific article

A serine protease isolated from the bristles of the Amazonic caterpillar, Premolis semirufa, is a potent complement system activator.

scientific article

Adaptive evolution in the toxicity of a spider's venom enzymes.

scientific article published on 21 December 2015

Administration of M. leprae Hsp65 interferes with the murine lupus progression.

scientific article

African adders: partial characterization of snake venoms from three Bitis species of medical importance and their neutralization by experimental equine antivenoms

scientific article published on 2 February 2015

Analysis of Spleen Cells in Susceptible and Resistant Mice with Experimental Lagochilascariosis

scientific article published on 12 September 2012

Analysis of the toxic potential of venom from Loxosceles adelaida, a Brazilian brown spider from karstic areas.

scientific article published on 21 January 2005

Angiotensin-degrading serine peptidase: a new chymotrypsin-like activity in the venom of Bothrops jararaca partially blocked by the commercial antivenom.

scientific article published on 10 November 2011

Animal venoms/toxins and the complement system

scientific article published on 03 July 2014

Antibody response from whole-cell pertussis vaccine immunized Brazilian children against different strains of Bordetella pertussis.

scientific article

Anticomplementary activity of horse IgG and F(ab')2 antivenoms.

scientific article published on 20 January 2014

Antigenic cross-reactivity and immunogenicity of Bothrops venoms from snakes of the Amazon region

scientific article published on 29 December 2009

Antivenom Production against Bothrops jararaca and Bothrops erythromelas Snake Venoms Using Cross-Linked Chitosan Nanoparticles as an Immunoadjuvant.

scientific article published on 16 April 2018

Autoimmune uveitis: study of treatment therapies

scientific article

Biotinylation a fast and reproducible method for labelling Trypanosoma cruzi cell surface proteins

scientific article published on 01 June 1993

Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.

scientific article published on January 2000

C5a receptor is cleaved by metalloproteases induced by sphingomyelinase D from Loxosceles spider venom.

scientific article published on 10 January 2012

Caissarolysin I (Bcs I), a new hemolytic toxin from the Brazilian sea anemone Bunodosoma caissarum: purification and biological characterization.

scientific article published on 17 January 2006

Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands.

scientific article published on 15 January 2016

Characterization of anti-crotalic antibodies

scientific article published on 08 February 2013

Characterization of phenotypes of immune cells and cytokines associated with chronic exposure to Premolis semirufa caterpillar bristles extract

scientific article

Characterization of the gene encoding component C3 of the complement system from the spider Loxosceles laeta venom glands: Phylogenetic implications

scientific article published on 24 May 2016

Clinical aspects, diagnosis and management of Loxosceles spider envenomation: literature and case review

scientific article published on 30 March 2020

Comparative analysis of a Bordetella pertussis patient isolated strain and classical strains used in the pertussis vaccine

scientific article published on 01 July 2005

Comparison of the C-mediating killing activity and C-activating properties of mouse monoclonal and polyclonal antibodies against Trypanosoma cruzi.

scientific article published on January 1992

Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: Chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity.

scientific article

Conformational changes of Loxosceles venom sphingomyelinases monitored by circular dichroism.

scientific article published in February 2005

Crystallization and preliminary crystallographic analysis of SMase I, a sphingomyelinase from Loxosceles laeta spider venom.

scientific article

Ctenus medius and Phoneutria nigriventer spiders venoms share noxious proinflammatory activities.

scientific article published in January 2009

Cytotoxic and genotoxic effects on human keratinocytes triggered by sphingomyelinase D from Loxosceles venom

scientific article published on 30 June 2020

Detection of Trypanosoma-decay accelerating factor antibodies in mice and humans infected with Trypanosoma cruzi

scientific article published on 01 June 1995

Diversity of Micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization

scientific article

Effect of Trypanosoma cruzi membrane components on the formation of the classical pathway C3 convertase

scientific article published on 01 January 1986

Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators.

scientific article published in February 1998

Enzymatic and Pro-Inflammatory Activities of Bothrops lanceolatus Venom: Relevance for Envenomation.

scientific article published on 7 August 2017

Erratum: Adaptive evolution in the toxicity of a spider's venom enzymes

scientific article published on 7 March 2016

Human complement activation and anaphylatoxins generation induced by snake venom toxins from Bothrops genus ⬇️

scientific article published on July 31, 2010

IgY: a promising antibody for use in immunodiagnostic and in immunotherapy.

scientific article published on 07 January 2010

Immunological parameters related to the adjuvant effect of the ordered mesoporous silica SBA-15

scientific article published on 25 October 2010

Incorporation of a 35-kilodalton purified protein from Loxosceles intermedia spider venom transforms human erythrocytes into activators of autologous complement alternative pathway.

scientific article

Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms

scientific article published on 01 September 2000

Inhibition of local effects induced by Bothrops erythromelas snake venom: Assessment of the effectiveness of Brazilian polyvalent bothropic antivenom and aqueous leaf extract of Jatropha gossypiifolia

scientific article published on 24 November 2016

Insights into scorpion venom peptides: alternative processing of β-KTx propeptide from Tityus serrulatus venom results in a new naturally occurring thimet oligopeptidase inhibitor

scientific article published on 08 December 2012

Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus.

scientific article

Ipomoea asarifolia neutralizes inflammation induced by Tityus serrulatus scorpion venom

scientific article published on 2 April 2014

Kn-Ba: a novel serine protease isolated from snake venom with fibrinogenolytic and kinin-releasing activities

scientific article published on 13 December 2018

Lagochilascaris minor: experimental infection of C57BL/6 and BALB/c isogenic mice reveals the presence of adult worms.

scientific article published on 26 March 2008

Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase.

scientific article published on 13 December 2017

Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis

scientific article published on 01 January 2000

Loxosceles sphingomyelinase induces complement-dependent dermonecrosis, neutrophil infiltration, and endogenous gelatinase expression

scientific article published on 01 April 2005

Loxosceles spider venom induces the release of thrombomodulin and endothelial protein C receptor: implications for the pathogenesis of intravascular coagulation as observed in loxoscelism.

scientific article published on 9 January 2007

Loxosceles venom Sphingomyelinase D activates human blood leukocytes: Role of the complement system

scientific article published on 16 December 2017

Loxoscelism: From basic research to the proposal of new therapies.

scientific article published on 06 February 2010

Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor.

scientific article published on 20 January 2014

Microcirculation abnormalities provoked by Loxosceles spiders' envenomation.

scientific article

Micrurus snake species: Venom immunogenicity, antiserum cross-reactivity and neutralization potential

scientific article published on April 2016

Micrurus snake venoms activate human complement system and generate anaphylatoxins.

scientific article

Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation

scientific article published on 18 January 2019

Nanostructured SBA-15 silica as an adjuvant in immunizations with hepatitis B vaccine.

scientific article

Nanostructured SBA-15 silica: An effective protective vehicle to oral hepatitis B vaccine immunization

scientific article published on 20 June 2016

Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms.

scientific article published on 19 September 2014

Neutralizing effects of Mimosa tenuiflora extracts against inflammation caused by Tityus serrulatus scorpion venom.

scientific article published on 11 June 2014

New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms.

scientific article published on 14 February 2015

Ontogenetic development of Loxosceles intermedia spider venom

scientific article published on 01 April 1999

Ordered mesoporous silica SBA-15: a new effective adjuvant to induce antibody response

scientific article published on 01 February 2006

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade

scientific article

P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model

scientific article published on 24 November 2020

Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System

scientific article published on 07 November 2018

Preface to the special issue for the XXV International Complement Workshop

scientific article published on 22 July 2014

Premolis semirufa (Walker, 1856) Envenomation, Disease Affecting Rubber Tappers of the Amazon: Searching for Caterpillar-Bristles Toxic Components ⬇️

scientific article published on February 28, 2012

Presence of Loxosceles similis Moenkhaus, 1898 (Araneae, Sicariidae) in Serra da Bodoquena, State of Mato Grosso do Sul, Brazil

scientific article published in May 2001

Pro-inflammatory activities in elapid snake venoms.

scientific article published on July 1994

Quality of horse F(ab')2 antitoxins and anti-rabies immunoglobulins: protein content and anticomplementary activity.

scientific article

Self-Assembled Cationic-Covered Nanoemulsion as A Novel Biocompatible Immunoadjuvant for Antiserum Production Against Tityus serrulatus Scorpion Venom

scientific article published on 29 September 2020

Snake venoms from Angola: Intra-specific variations and immunogenicity

scientific article published on 16 April 2018

Snakebites and scorpion stings in the Brazilian Amazon: identifying research priorities for a largely neglected problem.

scientific article published on 21 May 2015

Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis

scientific article

Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis

scientific article published on 15 March 2006

Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis

scientific article published on 01 October 1998

Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine.

scientific article

Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D

scientific article

Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases.

scientific article published on 3 February 2006

Susceptibility of different strains of mice to South American rattlesnake (Crotalus durissus terrificus) venom: correlation between lethal effect and creatine kinase release.

scientific article

Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism

scientific article published on 01 December 2019

Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom

scientific article published on 02 March 2017

Tetracycline protects against dermonecrosis induced by Loxosceles spider venom.

scientific article published on 11 January 2007

The Ex vivo Eye Irritation Test (EVEIT) model as a mean of improving venom ophthalmia understanding

scientific article published on 08 June 2018

The history of antivenoms development: Beyond Calmette and Vital Brazil

scientific article published on 17 May 2018

The humoral immune response induced by snake venom toxins.

scientific article published on October 2011

The improvement of the therapeutic anti-Lachesis muta serum production in horses

scientific article published on 01 March 2005

Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags

scientific article

Variations in Loxosceles spider venom composition and toxicity contribute to the severity of envenomation

scientific article published on 01 March 2005

Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System

scientific article published on 15 July 2018

Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation.

scientific article

Venomous caterpillars: From inoculation apparatus to venom composition and envenomation

scientific article published on 24 August 2018

[des-Arg(1)]-Proctolin: A novel NEP-like enzyme inhibitor identified in Tityus serrulatus venom

scientific article published on 6 June 2015

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