Search filters

List of works by Leon Schurgers

A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity

scientific article published on 02 June 2019

A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers.

scientific article published on 11 June 2018

Administration of vitamin K does not counteract the ectopic mineralization of connective tissues inAbcc6-/-mice, a model for pseudoxanthoma elasticum ⬇️

scientific article published on February 15, 2011

Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy

scientific article published on 24 January 2019

Annexin A5 reduces early plaque formation in ApoE -/- mice.

scientific article published on 21 December 2017

AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis

scientific article published in Scientific Reports

AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice

scientific article published on 12 September 2014

Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease

scientific article published on 24 February 2020

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

scientific article (publication date: October 2015)

Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin, and insulin metabolism in active acromegaly

scientific article published on 30 October 2009

Atypical presentation of pseudoxanthoma elasticum with abdominal cutis laxa: evidence for a spectrum of ectopic calcification disorders?

scientific article published on 30 September 2011

Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.

scientific article

Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.

scientific article published on 10 November 2017

Calcification inhibitors in vascular calciphylaxis associated with normal renal function

scientific article published on 23 October 2012

Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization.

scientific article published on 12 May 2011

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice

scientific article

Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species.

scientific article published on 5 August 2010

Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population

scientific article published on 17 December 2019

Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).

scientific article published on 4 January 2018

Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification.

scientific article

Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition.

scientific article published in June 2017

Circulating annexin A5 predicts mortality in patients with heart failure

scientific article

Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure

scientific article published on 01 August 2011

Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.

scientific article

Coronary Artery Calcification: A Janus-Faced Biomarker?

scientific article published on 19 July 2017

Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study.

scientific article published on 6 June 2018

Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling

scientific article published on 01 March 2022

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients.

scientific article published on 5 January 2018

Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis

scientific article published on 09 October 2014

Does statins promote vascular calcification in chronic kidney disease?

scientific article published on 30 December 2016

Ectopic calcification in β-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation.

scientific article published on 27 July 2013

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

scientific article published on 22 January 2019

Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers

scientific article published on 01 June 2013

High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification

scientific article published on 18 August 2015

Hydrolysed Formula Is a Risk Factor for Vitamin K Deficiency in Infants With Unrecognised Cholestasis ⬇️

scientific article published on 01 December 2010

Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S

scientific article published on 13 November 2012

Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study

scientific article published on 26 February 2018

Intimal and medial calcification in relation to cardiovascular risk factors

scientific article published on 13 July 2020

Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis

scientific article published on 10 November 2015

Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?

scientific article

Matrix Gla Protein Accumulates at the Border of Regions of Calcification and Normal Tissue in the Media of the Arterial Vessel Wall ⬇️

scientific article published on November 30, 2001

Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls ⬇️

scientific article published on December 6, 2012

Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma.

scientific article published on 27 August 2009

Mechanisms of arterial remodeling: lessons from genetic diseases ⬇️

scientific article published on December 13, 2012

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries ⬇️

scientific article published on April 30, 2011

Missense mutation of VKORC1 leads to medial arterial calcification in rats

scientific article published in Scientific Reports

Molecular Imaging to Identify the Vulnerable Plaque—From Basic Research to Clinical Practice ⬇️

scientific article published on October 1, 2012

Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake.

scientific article

Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum

scientific article published on 05 September 2013

Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.

scientific article published on 7 February 2015

New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs)

scientific article

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate

scientific article published on 28 March 2021

Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients

scientific article published on 20 July 2011

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet

scientific article

Pharmacological and Nutritional Modulation of Vascular Calcification

scientific article published on 30 December 2019

Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.

scientific article

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.

scientific article published on 16 May 2017

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

scientific journal article

Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact?

scientific article

Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification.

scientific article published on 19 January 2017

Rapidly Progressive Severe Vascular Calcification Sparing the Kidney Allograft Following Warfarin Initiation ⬇️

scientific article published on December 1, 2010

Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study

scientific article

Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome

scientific article published on 06 July 2018

Response to letter to the editor: annexin A5 levels or circulating microparticles: what we see depends mainly on what we look for

scientific article published on 18 January 2016

Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation

scientific article published on 30 May 2019

Role of vitamin K-dependent proteins in the arterial vessel wall ⬇️

scientific article published on June 29, 2011

Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug-Bug Interaction?

scientific article published on 27 May 2020

Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.

scientific article published in May 2017

Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon

scientific article published on 09 October 2018

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

scientific article published on 07 March 2019

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes

scientific article published on 14 November 2019

The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study.

scientific article

The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial

scientific article published on 01 October 2019

The realm of vitamin K dependent proteins: shifting from coagulation toward calcification.

scientific article published on 17 February 2014

The role of kidney transplantation and phosphate binder use in vitamin K status

scientific article published on 30 August 2018

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling.

scientific article published on 21 March 2018

Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis

scientific article published on November 2010

Uremic Toxins and Vascular Calcification-Missing the Forest for All the Trees

scientific article published on 29 September 2020

Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging.

scientific article

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.

scientific article published on 27 April 2017

Vascular Calcification and not Arrhythmia in Idiopathic Atrial Fibrillation Associates with Sex Differences in Diabetic Microvascular Injury miRNA Profiles

scientific article published on 01 January 2019

Vascular calcification in chronic kidney disease: an update.

scientific article

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists ⬇️

scientific article published on April 18, 2012

Vascular smooth muscle cell calcification is mediated by regulated exosome secretion

scientific article published on 23 February 2015

Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage

scientific article published on 20 December 2019

Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?

scientific article published on 14 October 2015

Vitamin K deficiency in critical ill patients; a prospective observational study

scientific article published on 28 October 2018

Vitamin K intake and status are low in hemodialysis patients

scientific article published on 30 May 2012

Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum.

scientific article published on 02 July 2011

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization ⬇️

scientific article published on January 30, 2013

Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): a rationale and study protocol.

scientific article

Vitamin K2 Needs an RDI Separate from Vitamin K1

scientific article published on 21 June 2020

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease

article

Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease.

scientific article published in May 2013

Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients

scientific article

What's in a name? The pharmacy of vitamin K.

scientific article

Paulina is supported by:

About Paulina

Help