List of works - Roberto F Speck

Activation of NF-κB via endosomal Toll-like receptor 7 (TLR7) or TLR9 suppresses murine herpesvirus 68 reactivation

scientific article

Anti-HIV state but not apoptosis depends on IFN signature in CD4+ T cells

scientific article

Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich.

scientific article

Antiviral Activity of HIV gp120 Targeting Bispecific T Cell Engager (BiTE®) Antibody Constructs.

scientific article

CCTTT-repeat polymorphism of the inducible nitric oxide synthase is not associated with HIV pathogenesis

article

Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

scientific article published in September 2009

Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

scholarly article

Distinct ex vivo susceptibility of B-cell subsets to epstein-barr virus infection according to differentiation status and tissue origin

scientific article published on 5 March 2008

Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects

article

Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases

scientific article published on 29 May 2013

Evaluation of the Immunomodulatory and Antiviral Effects of the Cytokine Combination IFN-α and IL-7 in the Lymphocytic Choriomeningitis Virus and Friend Retrovirus Mouse Infection Models ⬇️

scientific article published on September 19, 2011

Fish oil protects mice against acetaminophen hepatotoxicity in vivo

scientific article published on 01 March 1991

HIV interferes with SOCS‐1 and ‐3 expression levels driving immune activation ⬇️

scientific article published on February 21, 2011

HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo

scientific article

HIV-1 vaccination--is there hope?

scientific article

HIV-Diagnostik in der Schweiz und ärztlicher Abklärungsgang von HIV-Infizierten

article

HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load

scientific article published on 17 March 2004

Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue

scientific article

Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression.

scientific article

Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1

scientific article (publication date: 2012)

Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

scientific article published on 5 April 2007

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice

scientific article published on 14 February 2020

Impact of TNFα, LTα, FcγRII and complement receptor on HIV-1 trapping in lymphoid tissue from HIV-infected patients

article

Impact of genotypic resistance testing on selection of salvage regimen in clinical practice.

scientific article published in October 2003

Impaired CD8+ T-cell reactivity against viral antigens in cancer patients with solid tumors.

scientific article published in October 2004

Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization

scientific article published on 28 November 2016

Inadequate clearance of translocated bacterial products in HIV-infected humanized mice

scientific article

Interferon α-Enhanced Clearance of Group A Streptococcus Despite Neutropenia.

scientific article published on 18 April 2016

Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice

scientific article published on 22 April 2015

Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis.

scientific article

Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells.

scientific article

Modeling HIV infection and therapies in humanized mice ⬇️

scientific article published on 09 July 2012

Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART

article

Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption ⬇️

scientific article published on May 3, 2011

Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction

scientific article

Pharmacokinetics and chronic toxicity of cyclosporine A in genetic hydroxylation-deficient dark Agouti rats

scientific article published on 01 October 1990

Pharmacokinetics/pharmacodynamics of ketoconazole-prednisolone interaction

scientific article published on 01 February 1992

Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production

scientific article published in December 2009

Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection

scientific article published in February 2007

Prednisolone stimulates hepatic glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo

scientific article published on 01 April 1993

Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.

scientific article published in March 2002

Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.

scientific article published on 07 December 2016

Rapid detection of the CCR2-V64I, CCR5-A59029G and SDF1-G801A polymorphisms by tetra-primer PCR

scientific article published on 01 July 2002

Rapidly destructive Staphylococcus epidermidis endocarditis.

scientific article published in June 2005

Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.

scientific article

Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies

scientific article published on 7 February 2016

Reply to Hasenkrug et al., "Different Biological Activities of Specific Interferon Alpha Subtypes"

scientific article published on 24 July 2019

Similar efficacy of broad-range ITS PCR and conventional fungal culture for diagnosing fungal infections in non-immunocompromised patients.

scientific article

Supplementation of N-acetylcysteine fails to increase glutathione in lymphocytes and plasma of patients with AIDS

scientific article published on 01 January 1995

TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection.

scientific article published on March 2006

TLR8 activates HIV from latently infected cells of myeloid-monocytic origin directly via the MAPK pathway and from latently infected CD4+ T cells indirectly via TNF-α.

scientific article published on 28 February 2011

TLR9 triggering in Burkitt's lymphoma cell lines suppresses the EBV BZLF1 transcription via histone modification.

scientific article

Telomerase activity impacts on Epstein-Barr virus infection of AGS cells

scientific article published on 9 April 2015

Triggering TLR2, -3, -4, -5, and -8 reinforces the restrictive nature of M1- and M2-polarized macrophages to HIV.

scientific article

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology

scientific article published on 29 September 2008

Ultrasensitive quantitative HIV-1 p24 antigen assay adapted to dried plasma spots to improve treatment monitoring in low-resource settings

article

Uncoupled anti-HIV and immune-enhancing effects when combining IFN-alpha and IL-7.

scientific article published in September 2005

Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease

scientific article

Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs

scientific article published on 3 July 2015

[Prevention of HIV and other sexually transmitted infections (STI)]

scientific article published on 01 August 2014

beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection

scientific article

List of works by Roberto F Speck

Activation of NF-κB via endosomal Toll-like receptor 7 (TLR7) or TLR9 suppresses murine herpesvirus 68 reactivation

Anti-HIV state but not apoptosis depends on IFN signature in CD4+ T cells

Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich.

Antiviral Activity of HIV gp120 Targeting Bispecific T Cell Engager (BiTE®) Antibody Constructs.

CCTTT-repeat polymorphism of the inducible nitric oxide synthase is not associated with HIV pathogenesis

Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

Distinct ex vivo susceptibility of B-cell subsets to epstein-barr virus infection according to differentiation status and tissue origin

Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects

Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases

Evaluation of the Immunomodulatory and Antiviral Effects of the Cytokine Combination IFN-α and IL-7 in the Lymphocytic Choriomeningitis Virus and Friend Retrovirus Mouse Infection Models ⬇️

Fish oil protects mice against acetaminophen hepatotoxicity in vivo

HIV interferes with SOCS‐1 and ‐3 expression levels driving immune activation ⬇️

HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo

HIV-1 vaccination--is there hope?

HIV-Diagnostik in der Schweiz und ärztlicher Abklärungsgang von HIV-Infizierten

HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load

Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue

Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression.

Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1

Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice

Impact of TNFα, LTα, FcγRII and complement receptor on HIV-1 trapping in lymphoid tissue from HIV-infected patients

Impact of genotypic resistance testing on selection of salvage regimen in clinical practice.

Impaired CD8+ T-cell reactivity against viral antigens in cancer patients with solid tumors.

Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization

Inadequate clearance of translocated bacterial products in HIV-infected humanized mice

Interferon α-Enhanced Clearance of Group A Streptococcus Despite Neutropenia.

Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice

Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis.

Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells.

Modeling HIV infection and therapies in humanized mice ⬇️

Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART

Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption ⬇️

Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction

Pharmacokinetics and chronic toxicity of cyclosporine A in genetic hydroxylation-deficient dark Agouti rats

Pharmacokinetics/pharmacodynamics of ketoconazole-prednisolone interaction

Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production

Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection

Prednisolone stimulates hepatic glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo

Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.

Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.

Rapid detection of the CCR2-V64I, CCR5-A59029G and SDF1-G801A polymorphisms by tetra-primer PCR

Rapidly destructive Staphylococcus epidermidis endocarditis.

Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.

Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies

Reply to Hasenkrug et al., "Different Biological Activities of Specific Interferon Alpha Subtypes"

Similar efficacy of broad-range ITS PCR and conventional fungal culture for diagnosing fungal infections in non-immunocompromised patients.

Supplementation of N-acetylcysteine fails to increase glutathione in lymphocytes and plasma of patients with AIDS

TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection.

TLR8 activates HIV from latently infected cells of myeloid-monocytic origin directly via the MAPK pathway and from latently infected CD4+ T cells indirectly via TNF-α.

TLR9 triggering in Burkitt's lymphoma cell lines suppresses the EBV BZLF1 transcription via histone modification.

Telomerase activity impacts on Epstein-Barr virus infection of AGS cells

Triggering TLR2, -3, -4, -5, and -8 reinforces the restrictive nature of M1- and M2-polarized macrophages to HIV.

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology

Ultrasensitive quantitative HIV-1 p24 antigen assay adapted to dried plasma spots to improve treatment monitoring in low-resource settings

Uncoupled anti-HIV and immune-enhancing effects when combining IFN-alpha and IL-7.

Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease

Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs

[Prevention of HIV and other sexually transmitted infections (STI)]

beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection