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List of works by Philip J Rosenthal

"The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health

scientific article

1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues

scientific article

1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation

scientific article published on 3 January 2014

4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation

scientific article published on 22 July 2017

4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation

scientific article published on 15 September 2016

4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation

scientific article

5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel

scientific article published on December 2003

7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation

scientific article published on 14 March 2014

A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2.

scientific article published on 12 April 2007

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

scientific article

Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study

scientific article

Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria

scientific article

Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme

scientific article published on 16 March 2015

Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.

scientific article

Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

scientific article published on November 2005

An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia

scientific article

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites

scientific article published on 12 July 2013

An image-based assay for high throughput screening of Giardia lamblia

scientific article

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

scientific article published on 3 December 2007

Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.

scientific article published on 20 December 2005

Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic

scientific article

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

scientific article published on 06 June 2016

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

scientific article

Antimalarial activities of novel synthetic cysteine protease inhibitors

scientific article

Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors

scientific article

Antimalarial compounds from the stem bark of Vismia laurentii.

scientific article

Antimalarial drug discovery: efficacy models for compound screening

scientific article published on June 2004

Antimalarial drug discovery: old and new approaches ⬇️

scientific article published on November 1, 2003

Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin

scientific article

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

article published in the Proceedings of the National Academy of Sciences of the United States of America

Antiparasitic activities of novel, orally available fumagillin analogs

scientific article

Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon.

scientific article published on 20 March 2009

Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes

scientific article published on September 2004

Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis

scientific article published on 14 July 2013

Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children

scientific article published on November 2012

Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics

scientific article published on 29 April 2008

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts

scientific article published on August 2004

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol

scientific article published on 11 May 2006

Artefenomel: a promising new antimalarial drug

scientific article published in October 2015

Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda

scientific article

Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial

scientific article published on February 2007

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children

scientific article

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda

scientific article

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial

scientific article

Artemisinin Resistance Outside of Southeast Asia

article

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion ⬇️

scientific article published on June 27, 2011

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda

scientific article

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda

scientific article

Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children

scientific article

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

scientific article published on 03 May 2009

Artesunate for the treatment of severe falciparum malaria

scientific article published on April 2008

Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial

scientific article published on 23 November 2015

Association between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at Three Sites in Uganda

scientific article published on 01 January 2019

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates

scientific article published on 02 August 2021

Associations between aminoquinoline resistance genotypes and clinical presentations of Plasmodium falciparum infection in Uganda

scientific article published on 13 July 2020

Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda

scientific article

Associations between malaria preventive regimens and Plasmodium falciparum drug resistance mediating polymorphisms in Ugandan pregnant women

scientific article published on 05 October 2020

Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda

scientific article published on 10 February 2017

Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents

scientific article published on 14 October 2011

Azide-alkyne cycloaddition en route to 1 H -1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation ⬇️

scientific article published on February 5, 2013

Azithromycin for Malaria?

scientific article published on 23 May 2016

Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test

scientific article

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

scientific article published on 30 June 2021

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation ⬇️

scientific article published on June 9, 2012

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

scientific article

Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

scientific article published on 23 June 2015

Biochemical Properties of a Novel Cysteine Protease of Plasmodium vivax, Vivapain-4 ⬇️

scientific article published on October 12, 2010

Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

scientific article published on 11 September 2013

Biological evaluation of hydroxynaphthoquinones as anti-malarials

scientific article published on 10 July 2013

Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum

scientific article published in February 2005

Bis-alkylamine quindolone derivatives as new antimalarial leads

scientific article published on 12 August 2010

Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132

scientific article (publication date: 2013)

Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy ⬇️

scientific article published on December 8, 2010

Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria

article

Changes at our journal

scientific article published on January 2014

Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda

scientific article published on 29 December 2016

Changing antimalarial drug sensitivities in Uganda

scientific article published on 18 September 2017

Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda

scientific article published on 15 September 2016

Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review

scientific article published on June 2006

Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum

scientific article published on 29 June 2012

Clinical consequences of submicroscopic malaria parasitaemia in Uganda

scientific article published on 5 February 2018

Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial

scientific article published on May 2007

Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial

scientific article published on November 2004

Communicable Diseases: A Global Perspective

scientific article (publication date: 5 October 2016)

Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda

scientific article published on 25 September 2017

Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.

scientific article published on February 2003

Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children

scientific article

Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial

scientific article published on January 2008

Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids

scientific article

Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture

scientific article published on November 2008

Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda

scientific article published on 13 March 2006

Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants

scientific article published in December 2003

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

scientific article

Computer-Aided Drug Design of Falcipain Inhibitors: Virtual Screening, Structure–Activity Relationships, Hydration Site Thermodynamics, and Reactivity Analysis ⬇️

scientific article published on February 28, 2012

Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers

scientific article

Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

scientific article

Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target

scientific article

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity

scientific article published on 9 January 2008

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

scientific article published on 18 July 2016

Cysteine proteases in protozoan parasites

scholarly article by Jair Siqueira-Neto et al published 1 August 2018 in PLoS Neglected Tropical Diseases

Cysteine proteases of malaria parasites

scientific article

Cysteine proteases of malaria parasites: targets for chemotherapy

scientific article

Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance

scientific article published on March 2009

Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study

scientific article published on 11 September 2017

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

scientific article

Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine

scientific article

Design, Synthesis, and Development of Novel Guaianolide-Endoperoxides as Potential Antimalarial Agents ⬇️

scientific article published on November 11, 2010

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives

scientific article published on May 2005

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

scientific article published on 15 January 2011

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

scientific article published on October 31, 2010

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials

scientific article published on 9 May 2009

Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues

scientific article published on 5 October 2007

Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS.

scientific article published on January 2014

Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks

scientific article published on 15 June 2011

Development of protease inhibitors for protozoan infections

scientific article published on December 2008

Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda

scientific article

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

scientific article published on 12 May 2006

Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum

scientific article published on 14 April 2008

Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity

scientific article published on 15 July 2014

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

scientific article published in January 2005

Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.

scientific article published on February 2003

Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy

scientific article published on August 2005

Drug delivery to the malaria parasite using an arterolane-like scaffold

scientific article published on 14 October 2014

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

scientific article published on 21 March 2017

Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children ⬇️

scientific article published on January 1, 2011

Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study

scientific article published on 18 November 2005

Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members.

scientific article published on September 2006

Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance

scientific article

Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial

scientific article published on 21 July 2009

Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children

scientific article published on October 2007

Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine

scientific article

Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis

scientific article

Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial

scientific article published on November 2014

Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren

scientific article

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

scientific article published on 10 July 2017

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity

scientific article published on 27 October 2010

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.

scientific article

Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies ⬇️

scientific article published on May 5, 2011

Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction

scientific article

Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections

scientific article

Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors

scientific article published on 15 September 2004

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait

scientific article published on 10 February 2012

Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States

scientific article published on January 2017

Experimental malaria infection triggers early expansion of natural killer cells

scientific article published on 29 September 2008

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

scientific article published on 30 April 2015

FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii

scientific article published on 17 December 2010

Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda

scientific article published on August 2008

Falcipain 2 inhibitors and antiplasmodial compounds from a bio-guided fractionation of the fruits of Sorindeia juglandifolia A. Rich. (Anacardiaceae) growing in Cameroon.

scientific article

Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series ⬇️

scientific article published on August 26, 2010

Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole

scientific article published on 12 June 2007

Falcipain-2 inhibition by suramin and suramin analogues ⬇️

scientific article published on April 25, 2013

Falcipains and Other Cysteine Proteases of Malaria Parasites ⬇️

scientific article published on January 1, 2011

False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria

scientific article

Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion ⬇️

scientific article

Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite

scientific article published on December 2012

Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites

scientific article published on 24 June 2013

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

scientific article published on 20 September 2013

Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain

scientific article published on 4 February 2002

Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export

scientific article

Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda

scientific article published on 15 January 2010

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

scholarly article

Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum

scientific article published on 20 July 2006

Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance

scientific article published on March 2006

HIV RNA suppression among HIV-infected Ugandan children with measles

scientific article

HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda

scientific article published on December 2007

Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.

scientific article

Hepatotoxicity Due to a Drug Interaction between Amodiaquine plus Artesunate and Efavirenz

article

High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda

scientific article published on April 2008

Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial

scientific article published on 9 April 2009

Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors

scientific article

Host polymorphisms and the incidence of malaria in Ugandan children

scientific article published on December 2004

How Do We Best Diagnose Malaria in Africa? ⬇️

scientific article published on February 1, 2012

Human genetics and malaria: relevance for the design of clinical trials

scientific article published in November 2008

Hydrolysis of erythrocyte proteins by proteases of malaria parasites

scientific article

Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax

scientific article

Identification of Novel Malarial Cysteine Protease Inhibitors Using Structure-Based Virtual Screening of a Focused Cysteine Protease Inhibitor Library ⬇️

scientific article published on March 23, 2011

Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.

scientific article published on 10 September 2011

Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory

scientific article published in March 2006

Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity

scientific article published on 23 May 2008

Imidazoquines as antimalarial and antipneumocystis agents

scientific article published on December 2009

Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children

scientific article published on 9 March 2015

Impact of intermittent preventive treatment during pregnancy on Plasmodium falciparum drug resistance-mediating polymorphisms in Uganda

scientific article published on 22 August 2017

Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial

scientific article published on 12 March 2014

Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial

scientific article

Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility

scientific article

Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials

scientific article published on 25 June 2007

In Vitro and In Vivo Antimalarial Efficacies of Optimized Tetracyclines ⬇️

scientific article published on April 29, 2013

In vitro activity of antiretroviral drugs against Plasmodium falciparum

scientific article

In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites

scientific article

In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda

scientific article

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

scientific article published on 8 July 2011

Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children

scientific article

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

scientific article published on 5 January 2011

Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda

scientific article published on 28 December 2012

Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.

scientific article published on 18 November 2003

Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity

scientific article published on 11 July 2016

Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins

scientific article published on 7 May 2012

Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission

scientific article published on August 2009

Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays

scientific article published in June 2015

Lessons from Sickle Cell Disease in the Treatment and Control of Malaria ⬇️

scientific article published on June 30, 2011

Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center

scientific article published in September 2017

Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda

scientific article

Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria

scientific article

Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers

scientific article published in August 2009

Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward

scientific article

Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts

scientific article

Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control

scientific article published on 16 March 2015

Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda

scientific article published on 19 September 2017

Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial

scientific article

Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study

scientific article published on 8 November 2016

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids

scientific article published in March 2010

Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation

scientific article

Mining a cathepsin inhibitor library for new antiparasitic drug leads

scientific article

Molecular assays for antimalarial drug resistance surveillance: A target product profile

scientific article published in PLoS ONE

Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children

scientific article published on 24 May 2004

Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola ⬇️

scientific article published on August 24, 2011

Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda

scientific article published on 11 June 2008

Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast

scientific article

N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads

scientific article published on 8 January 2013

Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts ⬇️

scientific article published on 4 February 2012

Novel anti-plasmodial hits identified by virtual screening of the ZINC database

scientific article

Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes ⬇️

scientific article published on September 21, 2010

Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials

scientific article published on 28 May 2012

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities

scientific article

Novel potent metallocenes against liver stage malaria

scientific article published on 12 December 2011

Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities

scientific article

Novel squaramides with in vitro liver stage antiplasmodial activity

scientific article published on 03 March 2016

Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents

scientific article published on 2 March 2011

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences

scientific article published in September 2009

Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum

scientific article published on 29 May 2013

Pattern of malaria-specific T-cell responses in a cohort of Ugandan children

scientific article published on 4 November 2007

Persistent parasitemia despite dramatic reduction in malaria incidence after 3 rounds of indoor residual spraying in Tororo, Uganda

scientific article published on 01 March 2019

Perspectives on Ebola

scientific article published on 12 January 2015

Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda

scientific article

Phosphonium lipocations as antiparasitic agents ⬇️

scientific article published on February 23, 2012

Piperaquine exposure is altered by pregnancy, HIV and nutritional status in Ugandan women

scientific article published on 05 October 2020

Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation

scientific article published on 23 March 2017

Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda

scientific article

Plasmodium Species Infecting Children Presenting with Malaria in Uganda

scientific article published on September 2017

Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association with Artemisinin Resistance

scientific article published on 12 April 2018

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites

scholarly article

Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene

scientific article

Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'.

scientific article

Plasmodium food vacuole plasmepsins are activated by falcipains

scientific article published on 28 February 2008

Point of care testing for malaria using LAMP, loop mediated isothermal amplification

scientific article

Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children

scientific article (publication date: 2014)

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

scientific article

Potent antiplasmodial extracts from Cameroonian Annonaceae

scientific article published on 21 January 2011

Predicting optimal dihydroartemisinin-piperaquine regimens to prevent malaria during pregnancy for HIV-infected women receiving efavirenz

scientific article published on 19 December 2017

Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda

scientific article published on 29 June 2009

Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar

scientific article published on 18 December 2012

Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies

scientific article published on 28 January 2013

Prevention of Increasing Rates of Treatment Failure by Combining Sulfadoxine‐Pyrimethamine with Artesunate or Amodiaquine for the Sequential Treatment of Malaria ⬇️

scientific article published on October 10, 2003

Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.

scientific article published on December 2004

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

scientific article

Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies

scientific article published on March 2003

Prolonged Selection of pfmdr1 Polymorphisms After Treatment of Falciparum Malaria With Artemether-Lumefantrine in Uganda ⬇️

scientific article published on October 1, 2011

Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial

scientific article (publication date: August 2014)

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Academic review article discussing the merits of Quinine

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

scientific article published on 23 May 2013

Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso

scientific article published on 27 April 2015

Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso

scientific article published on 22 October 2007

Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda

scientific article published on February 2008

Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases

scientific article

Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum

scientific article

Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda

scientific article published on May 2004

Reply to Goyal et al.

scientific article published on 15 December 2014

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda

scientific article published on 11 June 2007

Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo

scientific article

Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.

scientific article published on July 2006

Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children

scientific article published on 11 June 2008

Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic

scientific article

Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport

scientific article published on 10 June 2004

Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso

scientific article (publication date: July 2014)

Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso

scientific article

Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda

scientific article published on December 2009

Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda

scientific article published on May 2006

Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children.

scientific article published on September 2003

Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy

scientific article

Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents

scientific article published on 13 September 2013

Stage-specific antimalarial activity of cysteine protease inhibitors

scientific article published in May 2002

Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease

scientific article (publication date: August 2006)

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability

scientific article published on 30 September 2013

Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones

scientific article

Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines

scientific article published in May 2003

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

scientific article

Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity

scientific article published on 24 January 2013

Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.

scientific article published on May 2005

Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial

scientific article

Synthesis and antimalarial activity of sulfonamide chalcone derivatives

scientific article published in April 2005

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum

scientific article published on 29 September 2006

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain

scientific article published in October 2003

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen

scientific article published on May 2002

Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives

scientific article published on May 2005

Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid

scientific article

Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials

scientific article published on 14 January 2007

Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds

scientific article

Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates

scientific article published on 20 March 2015

Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity

scientific article published on July 2010

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents

scientific article published on 10 December 2010

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

scientific article published in June 2004

Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2.

scientific article published on 2 December 2014

Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities

scientific article published on 10 October 2008

Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials

scientific article published on 8 December 2014

Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids

scientific article

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones

scientific article published on 23 December 2009

Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.

scientific article

Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry ⬇️

scientific article published on November 28, 2011

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

scientific article published on February 2017

Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda

scientific article (publication date: July 2014)

Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum

scientific article

Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials

scientific article published on 22 May 2014

Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents

scientific article published on 11 July 2013

The (International) American Society of Tropical Medicine and Hygiene

scientific article published on November 2016

The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda

scientific article

The Effect of HIV on Malaria in the Context of the Current Standard of Care for HIV-Infected Populations in Africa ⬇️

scientific article published on January 1, 2012

The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots

scientific article

The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif

scientific article

The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children

scientific article published on 27 August 2015

The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis

scientific article published on 11 April 2017

The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives

scientific article published on 7 September 2012

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

scientific article published on 31 March 2015

The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children

scientific article published on 20 October 2011

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

scientific article

The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005

scientific article

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

scientific article

Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation

scientific article published on 9 November 2013

Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children

scientific article published on 15 September 2009

Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria.

scientific article published on September 2003

Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda

scientific article published on 14 March 2014

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

scientific article

Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy

scientific article published on April 2014

World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria

scientific article

β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation

scientific article published on 21 July 2014

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