List of works by Karen Horsburgh

4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia.

scientific article

4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease

article

APOE epsilon3 gene transfer attenuates brain damage after experimental stroke

scientific article published on 28 June 2006

Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning

scientific article published on 28 June 2011

Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis.

scientific article published on 31 December 2016

Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion.

scientific article published in June 2001

Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease.

scientific article published on 5 February 2011

Angiotensin II-inhibition: effect on Alzheimer's pathology in the aged triple transgenic mouse.

scientific article published on 12 April 2012

ApoE isoform-specific regulation of regeneration in the peripheral nervous system

scientific article

Apolipoprotein E and the CNS response to injury.

scientific article published in May 1998

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

scientific article published in Scientific Reports

Axon-glial disruption: the link between vascular disease and Alzheimer's disease?

scientific article published on August 2011

Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice

scientific article published on 30 June 2017

Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia

scientific article

Controlled hypertension induces cerebrovascular and gene alterations in Cyp1a1-Ren2 transgenic rats.

scientific article published on 8 October 2013

Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice

scientific article published on 01 November 2004

Differential alterations of second messenger systems and cerebral glucose use following excitotoxic lesion of rat cerebral cortex ⬇️

scientific article published on November 1, 1991

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.

scientific article

Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion ⬇️

scientific article published on 11 April 2017

Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype

scientific article published on January 2003

Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia.

scientific article published in October 2002

Extension of cerebral hypoperfusion and ischaemic pathology beyond MCA territory after intraluminal filament occlusion in C57Bl/6J mice

scientific article

Focal increases in [3H]forskolin and [3H]phorbol 12,13-dibutyrate binding in the rat brain following lesions of the medial septum.

scientific article published in March 1993

Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia

scientific article

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia ⬇️

scientific article published on 14 December 2015

Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

scientific article

Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory.

scientific article published on 13 October 2015

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

scientific article published on 19 November 2014

Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice

scientific article

Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion.

scientific article published in August 2001

Intracortical Glutamate Perfusionin VivoInduces Cellular Alterations in Specific Protein Kinase C Isoforms and Amyloid Precursor Protein

scientific article published on 01 February 1997

Intraventricular Infusion of Apolipoprotein E Ameliorates Acute Neuronal Damage after Global Cerebral Ischemia in Mice

scientific article published on 01 March 2000

Kindling-induced changes of protein kinase C levels in hippocampus and neocortex

scientific article published on January 1, 1992

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

scientific article published on 27 June 2017

MRI is a sensitive marker of subtle white matter pathology in hypoperfused mice

scientific article published on 30 December 2010

Marked alterations in the cellular localisation and levels of apolipoprotein E following acute subdural haematoma in rat.

scientific article published in July 1997

Mild fluid percussion injury in mice produces evolving selective axonal pathology and cognitive deficits relevant to human brain injury

scientific article

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

scientific article published on 21 December 2010

Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion.

scientific article

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

scientific article

Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice.

scientific article published in January 2004

Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and -2 in ischemic brain injury.

scientific article published on 18 January 2007

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge

scientific article (publication date: 2012)

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge

scientific article published on 2 February 2012

Recent progress in translational research on neurovascular and neurodegenerative disorders

scientific article published on 3 January 2017

Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography.

scientific article

Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion

scientific article (publication date: 2014)

Selective white matter pathology induces a specific impairment in spatial working memory

scientific article published on 20 October 2010

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. ⬇️

scientific article

Small vessels, dementia and chronic diseases-molecular mechanisms and pathophysiology.

scientific article published in November 2016

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

scientific article published on 23 March 2008

The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion ⬇️

scientific article

The human NACP/α-synuclein gene: chromosome assignment to 4q21.3–q22 and TaqI RFLP analysis ⬇️

scientific article published on March 20, 1995

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults

scientific article

White matter degeneration in vascular and other ageing-related dementias

scientific article published on 6 December 2017

White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion

scientific article published on 11 October 2014

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