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List of works by Charlotte Ling

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

scientific article

A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits

scientific article

A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome.

scientific article

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

scientific article

A central role for GRB10 in regulation of islet function in man.

scientific article published on 3 April 2014

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

scientific article published on 25 February 2009

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

scientific article published on January 2011

A common variant near the PRL gene is associated with increased adiposity in males

scientific article published on 26 August 2010

A single nucleotide polymorphism associates with the response of muscle ATP synthesis to long-term exercise training in relatives of type 2 diabetic humans

scientific article published on 21 December 2011

A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue

scientific article

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

scientific article

Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding

scientific article published on 11 January 2016

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle

article

Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes

scientific article published on 8 May 2014

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

scientific article

Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes

scientific article published on 18 August 2009

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

scientific article published on 8 March 2013

DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes

scientific article published on June 2015

DNA methylation in the pathogenesis of type 2 diabetes in humans.

scientific article published on 7 February 2018

DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes

scientific article published on 3 October 2017

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

scientific article published on 05 May 2016

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

scientific article

Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes

scientific article

Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner

scientific article published on 21 April 2010

Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors

scientific article published in September 2006

Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium

scientific article published on April 2016

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

scientific article published on 21 September 2017

Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice

scientific article published on 2 July 2008

Dnmt3a is an epigenetic mediator of adipose insulin resistance.

scientific article published in November 2017

Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?

scientific article

Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?

scientific article

Effect of exercise on DNA methylation and metabolism in human adipose tissue and skeletal muscle

scientific article published in December 2013

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

scientific article

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

scientific article published on 08 September 2012

Elevated serum chemokine CXC ligand 5 levels are associated with hypercholesterolemia but not a worsening of insulin resistance in Chinese people

scientific article published on 25 May 2010

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

scientific article

Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels

scientific article

Epigenetic adaptation to regular exercise in humans

scientific article published on 14 March 2014

Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

scientific article published on 2 December 2016

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome

scientific article published on 15 March 2016

Epigenetic differences arise during the lifetime of monozygotic twins

scientific article

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

scientific article published on 01 September 2020

Epigenetic markers to further understand insulin resistance

scientific article

Epigenetic programming of adipose-derived stem cells in low birthweight individuals

scientific article published on 14 September 2016

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

scientific article

Epigenetic regulation of insulin action and secretion - role in the pathogenesis of type 2 diabetes

scientific article published on 03 May 2020

Epigenetics and obesity: the devil is in the details ⬇️

scientific article published on December 21, 2010

Epigenetics: a molecular link between environmental factors and type 2 diabetes

scientific article

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

scientific article published on 10 September 2019

Erratum: Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome

scientific article published on 9 May 2016

Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6-month exercise intervention

article

Fetal Hyperglycemia Changes Human Preadipocyte Function in Adult Life

scientific article published on 13 February 2017

First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle

article

Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

scientific article (publication date: November 2007)

Genetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twins

scientific article

Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscle

scientific article published in October 2005

Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins

scientific article (publication date: 2009)

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

scientific article published on 13 July 2010

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

scientific article

Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

scientific article

Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy

scientific article published on 6 August 2015

Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets

scientific article

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

scientific article published on 16 August 2019

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

scientific article published on 29 October 2016

Helsinki alert of biodiversity and health

scientific article published on 23 April 2015

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

scientific article published on 10 October 2016

Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

scientific article published on 17 November 2016

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

scientific article published on 23 February 2017

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

scientific article published on 6 March 2013

Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue

scientific article published in April 2003

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

article published in 2015

Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes

scientific article

Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial.

scientific article

Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle

scientific article published on 20 June 2007

Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

scientific article

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

scientific article

Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

scientific article

Isolation of differentially expressed aldose reductase in ovaries after estrogen withdrawal from hypophysectomized diethylstilbestrol treated rats: increased expression during apoptosis

scientific article published on 01 June 2000

Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls

scientific article published on 3 September 2015

Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring

scientific article published on 11 January 2021

Liver DNA methylation of FADS2 associates with FADS2 genotypex

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

scientific article

MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation

scientific article published on 07 August 2018

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

scientific article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

scientific article published in August 2007

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes

scientific article published on 07 July 2008

Molecular correlates for maximal oxygen uptake and type 1 fibers

scientific article

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

scientific article

NIH working group report-using genomic information to guide weight management: From universal to precision treatment

scientific article

Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects

scientific article published on 23 November 2011

Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese

scientific article published in March 2013

PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population

scientific article published on 10 September 2011

PRL receptor-mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling expression and suppresses insulin-induced leptin production in adipocytes in vitro

scientific article published on 01 November 2001

Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population

scientific article published on August 2011

Progressive prostate hyperplasia in adult prolactin transgenic mice is not dependent on elevated serum androgen levels

scientific article

Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice

scientific article published on 01 October 2000

Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

scientific article

Prolactin suppresses malonyl-CoA concentration in human adipose tissue.

scientific article published on 23 June 2009

RETRACTED: The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes

retracted scientific article

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

scientific article published on 23 August 2012

Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue

scientific article published on 08 July 2009

Regulation of core clock genes in human islets

scientific article published on 2 February 2012

Regulation of skeletal muscle PPAR delta mRNA expression in twins

scientific article published on 13 September 2007

Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins

scientific article published on 10 April 2007

Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels

scientific article published on 01 December 2018

Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

scientific article

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

article

Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes

scientific article published on 05 March 2009

Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia

scientific article published on October 2012

The association of mitochondrial content with prevalent and incident type 2 diabetes

scientific article published on 11 February 2010

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

scientific article published on 25 November 2017

The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes

article

The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes

article

The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes

scientific article

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

scientific article published on 21 September 2009

Transcriptional and Epigenetic Changes Influencing Skeletal Muscle Metabolism in Women With Polycystic Ovary Syndrome

scientific article published on 01 December 2018

Transcriptome and proteome analysis of soleus muscle of hormone-sensitive lipase-null mice

scientific article

Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo

scientific article

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis

scientific article

Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

scientific article

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

scientific article

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

scientific article published on 08 May 2014

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