List of works - H. Frederik Nijhout

A mathematical model for histamine synthesis, release, and control in varicosities.

scientific article published on 12 December 2017

A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism

scientific article published in October 2006

A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.

scientific article published on 25 February 2009

A mathematical model of glutathione metabolism

scientific article published on 28 April 2008

A mathematical model of the folate cycle: new insights into folate homeostasis

scientific article

A mathematical model of the methionine cycle

scientific article published in January 2004

A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites

scientific article published on 31 July 2013

A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network

scientific article published on 12 September 2013

A physiological perspective on the response of body size and development time to simultaneous directional selection

scientific article published in June 2005

A voltammetric and mathematical analysis of histaminergic modulation of serotonin in the mouse hypothalamus

scientific article published on 11 May 2016

Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model ⬇️

scientific article published on August 28, 2012

Body size determination in insects: a review and synthesis of size- and brain-dependent and independent mechanisms

scientific article published on 22 March 2013

Computational studies of the role of serotonin in the basal ganglia

scientific article published on 24 May 2013

Conflicting processes in the evolution of body size and development time

scientific article

Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis

scientific article

Corrigendum: In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry

scientific article published on 09 July 2019

Developmental mechanisms of body size and wing-body scaling in insects

scientific article

Escape from homeostasis

scientific article published on 19 September 2014

Evaluating old truths: Final adult size in holometabolous insects is set by the end of larval development

scientific article published in 2022

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology

scientific article published on 28 November 2019

Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry

Homeostasis and dynamic stability of the phenotype link robustness and plasticity

scientific article published on 10 April 2014

Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

scientific article published on 10 September 2009

Hormonal control of growth in the wing imaginal disks of Junonia coenia: the relative contributions of insulin and ecdysone.

scientific article published on 21 February 2018

In silico experimentation with a model of hepatic mitochondrial folate metabolism.

scientific article published on 6 December 2006

Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate

scientific article published on 5 March 2006

Mathematical Insights into the Effects of Levodopa ⬇️

scientific article published on July 4, 2012

Mathematical analysis of the regulation of competing methyltransferases

scientific article published on 14 October 2015

Mathematical model insights into arsenic detoxification

scientific article published on 26 August 2011

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis

scientific article published on July 2008

Mathematical modeling of the effects of glutathione on arsenic methylation

scientific article

Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers.

scientific article

Mathematical modeling: epidemiology meets systems biology

scientific article published in May 2006

Modeling folate, one-carbon metabolism, and DNA methylation

scientific article published on August 2008

Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato

scientific article

One-carbon metabolism during the menstrual cycle and pregnancy

scientific article published on 16 December 2021

Origin of the mechanism of phenotypic plasticity in satyrid butterfly eyespots

scientific article published on 11 February 2020

Plasticity of insect body size in response to oxygen: integrating molecular and physiological mechanisms

scientific article published on 14 May 2014

Predicting the response to simultaneous selection: genetic architecture and physiological constraints ⬇️

scientific article published on May 1, 2012

Propagation of fluctuations in biochemical systems, I: linear SSC networks.

scientific article published on 25 April 2007

Spiracular fluttering decouples oxygen uptake and water loss: a stochastic PDE model of respiratory water loss in insects

scientific article published in 2022

Spiracular fluttering increases oxygen uptake

scientific article published on 20 May 2020

Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the tobacco Hornworm, Manduca sexta

scientific article

Synergism and Antagonism of Proximate Mechanisms Enable and Constrain the Response to Simultaneous Selection on Body Size and Development Time: An Empirical Test Using Experimental Evolution

scientific article

Systems Biology of Phenotypic Robustness and Plasticity

scientific article published in August 2017

Systems biology of robustness and homeostatic mechanisms

scientific article published on 29 October 2018

Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells

scientific article

The Physiological Basis of Reaction Norms: The Interaction Among Growth Rate, the Duration of Growth and Body Size ⬇️

scientific article published on December 1, 2004

To plasticity and back again.

scientific article published on 12 March 2015

Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation.

scientific article

Ultrabithorax function in butterfly wings and the evolution of insect wing patterns

scientific article

Using mathematical models to understand metabolism, genes, and disease

scientific article published on 23 September 2015

Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo

scientific article

Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex

article

optix drives the repeated convergent evolution of butterfly wing pattern mimicry.

scientific article

List of works by H. Frederik Nijhout

A mathematical model for histamine synthesis, release, and control in varicosities.

A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism

A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.

A mathematical model of glutathione metabolism

A mathematical model of the folate cycle: new insights into folate homeostasis

A mathematical model of the methionine cycle

A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites

A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network

A physiological perspective on the response of body size and development time to simultaneous directional selection

A voltammetric and mathematical analysis of histaminergic modulation of serotonin in the mouse hypothalamus

Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model ⬇️

Body size determination in insects: a review and synthesis of size- and brain-dependent and independent mechanisms

Computational studies of the role of serotonin in the basal ganglia

Conflicting processes in the evolution of body size and development time

Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis

Corrigendum: In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry

Developmental mechanisms of body size and wing-body scaling in insects

Escape from homeostasis

Evaluating old truths: Final adult size in holometabolous insects is set by the end of larval development

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology

Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry

Homeostasis and dynamic stability of the phenotype link robustness and plasticity

Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

Hormonal control of growth in the wing imaginal disks of Junonia coenia: the relative contributions of insulin and ecdysone.

In silico experimentation with a model of hepatic mitochondrial folate metabolism.

Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate

Mathematical Insights into the Effects of Levodopa ⬇️

Mathematical analysis of the regulation of competing methyltransferases

Mathematical model insights into arsenic detoxification

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis

Mathematical modeling of the effects of glutathione on arsenic methylation

Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers.

Mathematical modeling: epidemiology meets systems biology

Modeling folate, one-carbon metabolism, and DNA methylation

Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato

One-carbon metabolism during the menstrual cycle and pregnancy

Origin of the mechanism of phenotypic plasticity in satyrid butterfly eyespots

Plasticity of insect body size in response to oxygen: integrating molecular and physiological mechanisms

Predicting the response to simultaneous selection: genetic architecture and physiological constraints ⬇️

Propagation of fluctuations in biochemical systems, I: linear SSC networks.

Spiracular fluttering decouples oxygen uptake and water loss: a stochastic PDE model of respiratory water loss in insects

Spiracular fluttering increases oxygen uptake

Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the tobacco Hornworm, Manduca sexta

Synergism and Antagonism of Proximate Mechanisms Enable and Constrain the Response to Simultaneous Selection on Body Size and Development Time: An Empirical Test Using Experimental Evolution

Systems Biology of Phenotypic Robustness and Plasticity

Systems biology of robustness and homeostatic mechanisms

Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells

The Physiological Basis of Reaction Norms: The Interaction Among Growth Rate, the Duration of Growth and Body Size ⬇️

To plasticity and back again.

Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation.

Ultrabithorax function in butterfly wings and the evolution of insect wing patterns

Using mathematical models to understand metabolism, genes, and disease

Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo

Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex

optix drives the repeated convergent evolution of butterfly wing pattern mimicry.