List of works by Robert W Sauerwein

A Macrophage Colony-Stimulating Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence

scientific article published in February 2018

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines

scientific article published on 31 May 2012

A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1

scientific article published on 01 May 2020

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

scientific article

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responses

scientific article published in November 2014

A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparum

scientific article

A plant-produced Pfs25 VLP malaria vaccine candidate induces persistent transmission blocking antibodies against Plasmodium falciparum in immunized mice

scientific article

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

scientific article published on 27 February 2018

A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria

scientific article

A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites

scientific article (publication date: 5 March 2004)

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase

scientific article

A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes

scientific article published on 21 December 2015

A sporozoite-based vaccination platform against human malaria

scientific article published on 24 August 2018

A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages

scientific article

A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial

scientific article

Age-dependent distribution of Plasmodium falciparum gametocytes quantified by Pfs25 real-time QT-NASBA in a cross-sectional study in Burkina Faso

scientific article published in April 2007

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines

scientific article published on 09 September 2016

An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria

scientific article published on 01 May 2020

Analysis of a Multi-component Multi-stage Malaria Vaccine Candidate--Tackling the Cocktail Challenge

scientific article published on 6 July 2015

Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry

scientific article published in October 2002

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

scientific article published on 4 February 2015

Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers

scientific article

Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity

scientific article published in January 2011

Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization

scientific article published on 01 May 2020

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

scientific article

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

scientific article published on 01 September 2019

Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates

scientific article published on 16 February 2012

Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies

scientific article

Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection

scientific article published on January 2009

Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

scientific article

BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection

scientific article

Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

scientific article published on 20 February 2012

Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization

scientific article

Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection

scientific article

CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research

scientific article published on 10 August 2021

Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch volunteers

scientific article published on 10 November 2017

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

scientific article

Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites

scientific article published on May 2006

Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children

scientific article

Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens

scientific article published on 17 October 2017

Comparison of clinical and parasitological data from controlled human malaria infection trials

scientific article (publication date: 2012)

Complement activation in experimental human malaria infection

scientific article published on 3 May 2007

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

scientific article

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana

scientific article

Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

scientific article

Controlled Human Malaria Infection with Graded Numbers of NF135.C10- or NF166.C8-Infected Mosquitoes

scholarly article by Marijke C C Langenberg et al published 16 July 2018 in American Journal of Tropical Medicine and Hygiene

Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites

scientific article

Controlled human malaria infection trials: How tandems of trust and control construct scientific knowledge

scientific article published on February 2016

Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites

scientific article published on 13 November 2012

Controlled human malaria infections using aseptic, purified cryopreserved Plasmodium falciparum sporozoites administered by needle and syringe

scientific article published on 22 September 2014

Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

scholarly article

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

scientific article published on 25 May 2016

Cross-species immunity in malaria vaccine development: two, three, or even four for the price of one?

scientific article

Cross-stage immunity for malaria vaccine development

scientific article published on 12 October 2015

Cytotoxic markers associate with protection against malaria in human volunteers immunized with Plasmodium falciparum sporozoites

scientific article

Diagnosis and treatment based on quantitative PCR after controlled human malaria infection

scientific article published on 05 August 2016

Distribution of Plasmodium vivax pvdhfr and pvdhps alleles and their association with sulfadoxine-pyrimethamine treatment outcomes in Indonesia

scientific article published on 22 September 2015

Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum

scholarly article

Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali

scientific article published in January 2010

Editorial: Malaria investments and activities: it is now! or never?

scientific article published in December 2002

Efficacy and safety of the mosquitocidal drug ivermectin to prevent malaria transmission after treatment: a double-blind, randomized, clinical trial

scientific article

Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite

scientific article

Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers

scientific article published on 21 May 2012

Empowering malaria vaccination by drug administration

scientific article published on 29 April 2010

Enhancement of naturally acquired immunity against malaria by drug use.

scientific article published on 26 January 2012

Erratum to: Diagnosis and treatment based on quantitative PCR after controlled human malaria infection

scientific article published on 28 October 2016

Expansion of IgG+ B-cells during mitogen stimulation for memory B-cell ELISpot analysis is influenced by size and composition of the B-cell pool

scientific article

Experimental human challenge infections can accelerate clinical malaria vaccine development

scientific article published in January 2011

Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species

scientific article published on July 2006

Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

scientific article published on 23 June 2017

Extended malaria parasite clearance time in African children following artemisinin-combination therapy enhances transmission to Anopheles mosquitoes

article

External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance

scientific article (publication date: 2014)

Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model

scientific article published on 12 October 2019

Gametocytemia and Attractiveness of Plasmodium falciparum-Infected Kenyan Children to Anopheles gambiae Mosquitoes

scientific article published on August 2017

Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes

scientific article

Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection.

scientific article published on 21 May 2007

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells

scientific article

Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial

scientific article published on 2 August 2006

HGF/MET signalling protects Plasmodium-infected host cells from apoptosis.

scientific article

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites

scientific article published on May 2015

Hitting hotspots: spatial targeting of malaria for control and elimination

scientific article published on 31 January 2012

How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection

scientific article published on 04 April 2013

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children.

scientific article published on 30 April 2018

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice

scientific article published on 9 October 2017

Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum

scientific article

Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report

scientific article published on 30 January 2014

Immune activation and induction of memory: lessons learned from controlled human malaria infection with Plasmodium falciparum

scientific article published on February 2016

Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

scientific article published on 17 October 2011

Impact of malaria preexposure on antiparasite cellular and humoral immune responses after controlled human malaria infection

scientific article

In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals

scientific article

Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers.

scientific article published on June 2017

Influenza virosomes: a flu jab for malaria?

scientific article published on 5 August 2008

Inhibitory effect of TNF-α on malaria pre-erythrocytic stage development: influence of host hepatocyte/parasite combinations

scientific article (publication date: 4 March 2011)

Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression

scientific article published on 13 June 2016

Interferon-γ--central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria

scientific article published on 07 July 2010

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

scientific article

Liver Injury in Uncomplicated Malaria is an Overlooked Phenomenon: An Observational Study

scholarly article by Isaie J Reuling et al published October 2018 in EBioMedicine

Liver or blood-stage arrest during malaria sporozoite immunization: the later the better?

scientific article published on 20 April 2013

Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells

scientific article

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

scientific article published on 22 April 2011

MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum

scientific article

Malaria in Wanokaka and Loli sub-districts, West Sumba District, East Nusa Tenggara Province, Indonesia.

scientific article

Malaria infected mosquitoes express enhanced attraction to human odor

scientific article

Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial

scientific article published on 6 March 2013

Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production

scientific article published in August 2006

Malaria transmission-blocking vaccines: the bonus of effective malaria control

scientific article published on 21 February 2007

Memory B-cell and antibody responses induced by Plasmodium falciparum sporozoite immunization

scientific article

Memory-like IFN-γ response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum

scientific article published in December 2010

Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection

scientific article

Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings.

scientific article

Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission

scientific article published on 15 December 2017

Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum

scientific article published on 15 March 2006

Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

scientific article published on 13 September 2017

Mosquito Infectivity and Parasitemia after Controlled Human Malaria Infection

scholarly article published by Robert W Sauerwein in 2018

Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites

scientific article published on 29 August 2015

NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections

scientific article published on 27 November 2012

Neuroschistosomiasis; an unexpected finding in a Dutch woman

scientific article published in January 2009

New approach for high-throughput screening of drug activity on Plasmodium liver stages

scientific article published on April 2006

No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria

scientific article published on 30 June 2006

Novel pantothenate derivatives for anti-malarial chemotherapy

scientific article

Odours of Plasmodium falciparum-infected participants influence mosquito-host interactions

scientific article published on 24 August 2017

On the way to eradicating malaria

scientific article published in January 2012

Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations

scientific article

PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs

scientific article

Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum

scientific article (publication date: October 2006)

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

scientific article

Phenotyping clinical resistance to chloroquine in Plasmodium vivax in northeastern Papua, Indonesia

scientific article

Plant-produced transmission blocking Plasmodium falciparum Pfs25 subunit and VLP based vaccine candidates.

scientific article published on 15 October 2012

Plasmodium berghei Δp52&p36 parasites develop independent of a parasitophorous vacuole membrane in Huh-7 liver cells

scientific article

Plasmodium falciparum Infection of Human Volunteers Activates Monocytes and CD16+ Dendritic Cells and Induces Upregulation of CD16 and CD1c Expression

scientific article

Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana

scientific article

Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya

scientific article

Plasmodium falciparum infection causes proinflammatory priming of human TLR responses

scientific article published in July 2007

Plasmodium liver load following parenteral sporozoite administration in rodents

scientific article published on 9 October 2012

Plasmodium-associated changes in human odor attract mosquitoes.

scientific article published on 16 April 2018

Pre-clinical evaluation of a -based whole-sporozoite malaria vaccine candidate

scholarly article by António M Mendes et al published 2018 in npj Vaccines

Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density.

scientific article published on 31 May 2018

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

scientific article published on 12 October 2015

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

scientific article published on 23 October 2017

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

scientific article published on 18 April 2013

Protection of Malian children from clinical malaria is associated with recognition of multiple antigens

scientific article

Protective Efficacy Induced by Genetically Attenuated Mid-to-Late Liver-Stage Arresting Plasmodium berghei Δmrp2 Parasites

scientific article published on 13 June 2016

Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load.

scientific article

Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity

scientific article

Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia

scientific article

Reduction and enhancement of Plasmodium falciparum transmission by endemic human sera

scientific article

Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase

scientific article

Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence

scientific article published on 14 August 2013

Responses to malarial antigens are altered in helminth-infected children

scientific article published on May 2009

Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled Trial

scientific article published on 28 December 2015

Salinomycin and other ionophores as a new class of antimalarial drugs with transmission-blocking activity

scientific article published on 8 June 2015

Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection

scientific article

Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, Indonesia

scientific article

Seasonal patterns of Plasmodium falciparum gametocyte prevalence and density in a rural population of Burkina Faso

scientific article published on 21 September 2007

Serious psychiatric symptoms after chloroquine treatment following experimental malaria infection

scientific article published on March 2005

Spatial Patterns of Plasmodium falciparum Clinical Incidence, Asymptomatic Parasite Carriage and Anopheles Density in Two Villages in Mali

scientific article

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

scientific article

Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial

scientific article

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

scientific article published in Nature Communications

Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

scientific article published in Nature Communications

Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation

scientific article

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria

scientific article

Submicroscopic Plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in Tanzania

scientific article

Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya

scientific article

Targeting Plasmodium PI(4)K to eliminate malaria

scientific article (publication date: 12 December 2013)

Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction

scientific article published in August 2004

The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial

scientific article

The Plasmodium falciparum male gametocyte protein P230p, a paralog of P230, is vital for ookinete formation and mosquito transmission

scientific article published in Scientific Reports

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

scientific article published on 16 July 2009

The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

scientific article

The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study

scientific article published on 31 May 2019

The complement system contributes to functional antibody-mediated responses induced by immunization with Plasmodium falciparum malaria sporozoites.

scientific article published on 7 May 2018

The dog that did not bark: malaria vaccines without antibodies

scientific article published on 18 May 2007

The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion

scientific article published on 17 July 2006

The first malaria vaccine: a significant milestone

scientific article published in January 2015

The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system

scientific article

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays

scientific article

Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility

scientific article

Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria

scientific article

Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy

scientific article

Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria

scientific article published on 10 August 2016

Transmission of Plasmodium falciparum in urban Yaoundé, Cameroon, is seasonal and age-dependent

scientific article published on July 2003

Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development

scientific article (publication date: May 2014)

Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes

scientific article (publication date: May 2014)

Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes

scientific article published on 10 February 2016

Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

scientific article

Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development

scientific article published on 15 March 2016

Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites

scientific article published on 10 June 2019

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