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List of works by Len Seymour

8th international conference on oncolytic virus therapeutics.

scientific article published in December 2014

A PTENtial cause for the selectivity of oncolytic viruses?

scientific article published in February 2016

Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth

scientific article published on 28 December 2015

Activity of a group B oncolytic adenovirus (ColoAd1) in whole human blood.

scientific article published on 20 February 2014

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1.

scientific article

Adenovirus-derived vectors for prostate cancer gene therapy

scientific article published on July 2010

Adenovirus: teaching an old dog new tricks

scientific article published on 01 September 2011

An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells

scientific article published on 18 November 2018

Attenuation of the Hypoxia Inducible Factor Pathway after Oncolytic Adenovirus Infection Coincides with Decreased Vessel Perfusion

scientific article published on 01 April 2020

Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples

scientific article published on 21 November 2019

British Society for Gene Therapy annual conference 2008.

scientific article

CTb targeted non-viral cDNA delivery enhances transgene expression in neurons.

scientific article published in April 2004

Clinical adenoviral gene therapy for prostate cancer

scientific article published on July 2010

Combining Oncolytic Adenovirus with Radiation-A Paradigm for the Future of Radiosensitization.

scientific article

Combining virotherapy and angiotherapy for the treatment of breast cancer.

scientific article published on 12 July 2013

Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus.

scientific article

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

scientific article

Convergent Evolution by Cancer and Viruses in Evading the NKG2D Immune Response

scientific article published on 18 December 2020

Development of a novel mammalian display system for selection of antibodies against membrane proteins

scientific article published on 30 October 2020

Directed evolution generates a novel oncolytic virus for the treatment of colon cancer

scientific article

Effect of Albumin and Polyanion on the Structure of DNA Complexes with Polycation Containing Hydrophilic Nonionic Block

scientific article published on 01 September 1999

Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

scientific article published in November 1987

Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction.

scientific article published on January 2016

Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells.

scientific article

External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase

scientific article published on 26 March 2020

Factors influencing retention of adenovirus within tumours following direct intratumoural injection.

scientific article published on 21 February 2008

Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells.

scientific article published on 21 January 2005

Group B adenovirus enadenotucirev infects polarised colorectal cancer cells efficiently from the basolateral surface expected to be encountered during intravenous delivery to treat disseminated cancer.

scientific article published on 2 March 2017

Hiroshi Maeda--defining the pathway to targeted cancer therapy

scientific article published in August 2007

Improved in vitro human tumor models for cancer gene therapy

scientific article published on 20 April 2015

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

scientific article published on 26 October 2015

Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

scientific article published on 12 May 2015

Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes.

scientific article

Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier ⬇️

scientific article published on January 1, 1995

Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs

scientific article

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas

scientific article

Macrophages and their interactions with oncolytic viruses.

scientific article published on 08 July 2015

Making Oncolytic Virotherapy a Clinical Reality: The European Contribution

scientific article published on 10 August 2017

Nanotherapeutics shielded with a pH responsive polymeric layer.

scientific article

Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery

scientific article published on 7 August 2014

Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.

scientific article published on May 1998

Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators.

scientific article

Oncolytic adenovirus expressing bispecific antibody targets T-cell cytotoxicity in cancer biopsies

scientific article published on 20 June 2017

Oncolytic viruses: finally delivering

scientific article

Optogenetic control of iPS cell-derived neurons in 2D and 3D culture systems using channelrhodopsin-2 expression driven by the synapsin-1 and calcium-calmodulin kinase II promoters

article

OvAd1, a Novel, Potent, and Selective Chimeric Oncolytic Virus Developed for Ovarian Cancer by 3D-Directed Evolution

scientific article published on 14 December 2016

Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection.

scientific article published on 19 September 2017

Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic–hydrophilic copolymers

scientific article published on 01 May 2000

Poly-L-glutamic acid derivatives as vectors for gene therapy.

scientific article published in March 2000

Polymer coatings for delivery of nucleic acid therapeutics ⬇️

scientific article published on February 18, 2012

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.

scientific article published in March 2001

Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus

scientific article

Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat

scientific article

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

scientific article

Selective permeabilization of the blood-brain barrier at sites of metastasis

scientific article published on 09 October 2013

Solid Tumor Immunotherapy with T Cell Engager-Armed Oncolytic Viruses

scientific article published on 13 September 2017

Synthetic Polymers Conjugated to Monoclonal Antibodies: Vehicles for Tumour-Targeted Drug Delivery ⬇️

scientific article published on January 1, 1991

Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

scientific article

Tissue-specific attenuation of oncolytic sindbis virus without compromised genetic stability.

scientific article published on April 2014

Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference

scientific article published on 04 September 2018

Ultrasound-enhanced drug delivery for cancer

scientific article (publication date: 4 November 2012)

Under Pressure: Elevated Blood Pressure Enhances Targeting of Tumors by Oncolytic Viruses.

scientific article published on February 2016

Virotherapy--cancer targeted pharmacology.

scientific article published on 16 December 2011

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