List of works - Aisling Dunne

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

scientific journal article

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.

scientific article published on 15 October 2014

Activation of human biliverdin-IXα reductase by urea: generation of kinetically distinct forms during the unfolding pathway.

scientific article published on 21 September 2013

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

scientific article

Adaptor usage and Toll-like receptor signaling specificity

scientific article

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

scientific article published on 17 November 2018

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

scientific article published on 30 April 2003

Calcium crystal deposition diseases - beyond gout

scientific article published on 01 October 2018

Calcium crystals and auto-inflammation

scientific article published on 01 January 2020

Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells.

scientific article published on 22 June 2016

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

scientific article published on 25 January 2019

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

scientific article

Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.

scientific article

Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering

scientific article published on 11 June 2019

Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

scientific article published on 14 February 2017

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

scientific article published on 16 April 2010

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

scientific article published on November 2016

Immune modulation: IL-1, master mediator or initiator of inflammation

scientific article published on 01 December 2009

Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis

scientific article published on 7 July 2010

Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling.

scientific article published on 14 July 2016

Investigating inflammasome activation under conditions of cellular stress and injury

scientific article published on January 2015

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

scientific article

Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors

scientific article

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

scientific article published on 26 January 2006

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

scientific article published on December 2016

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

scholarly article

Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment.

scientific article published on 6 July 2018

New insights into the post-translational modification of Toll-like receptor signaling molecules

scientific article

Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner.

scientific article published on 2 November 2017

Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

scientific article published on 7 February 2017

Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase

scientific article published on 13 July 2012

Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1

article

S100A8 acts as an autocrine priming signal for heme-induced human Mϕ pro-inflammatory responses in hemolytic inflammation

scientific article published on 15 May 2019

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

scientific article

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

scientific article

Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation.

scientific article published on 21 July 2016

TLR based therapeutics

scientific article published on 16 April 2011

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

scientific article

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain

scientific article

The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling

scientific article published on 31 July 2019

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

scientific article published on 25 February 2003

Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues

scientific article published on 04 October 2018

Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).

scientific article published on 12 September 2011

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

scientific article published on 11 September 2019

List of works by Aisling Dunne

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.

Activation of human biliverdin-IXα reductase by urea: generation of kinetically distinct forms during the unfolding pathway.

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Adaptor usage and Toll-like receptor signaling specificity

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

Calcium crystal deposition diseases - beyond gout

Calcium crystals and auto-inflammation

Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells.

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.

Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering

Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

Immune modulation: IL-1, master mediator or initiator of inflammation

Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis

Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling.

Investigating inflammasome activation under conditions of cellular stress and injury

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment.

New insights into the post-translational modification of Toll-like receptor signaling molecules

Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner.

Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase

Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1

S100A8 acts as an autocrine priming signal for heme-induced human Mϕ pro-inflammatory responses in hemolytic inflammation

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation.

TLR based therapeutics

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain

The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues

Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages