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List of works by Michael R Ehrenstein

Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus

scholarly article by Elizabeth C Jury et al published February 2010 in European Journal of Immunology

Access to the next wave of biologic therapies (Abatacept and Tocilizumab) for the treatment of rheumatoid arthritis in England and Wales: addressing treatment outside the current NICE guidance

scientific article

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

scientific article

An open study of B lymphocyte depletion in systemic lupus erythematosus

scientific article published in October 2002

Analysis of immunoglobulin variable region genes of a human IgM anti-myeloperoxidase antibody derived from a patient with vasculitis.

scientific article published in February 1996

Anti-TNF antibody therapy induces IL-17 suppressing regulatory T cells in patients with rheumatoid arthritis

scholarly article by Jenny McGovern et al published 2012 in Arthritis Research and Therapy

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.

scientific article

Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta

scientific article published on 2 January 2007

Antibodies and other biomarkers – pathological consequences (2)

scientific article published on 01 March 2008

Antibody diversification and selection in the mature B-cell compartment.

scientific article

Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 mice

scientific article published in December 2004

Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus

scientific article published in November 2006

B cell depletion in systemic lupus erythematosus.

scientific article published on January 2007

B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis.

scientific article published on 18 November 2013

B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients.

scientific article published on 27 September 2005

B-cell numbers and phenotype at clinical relapse following rituximab therapy differ in SLE patients according to anti-dsDNA antibody levels

scientific article

Belimumab after B cell depletion therapy in patients with systemic lupus erythematosus (BEAT Lupus) protocol: a prospective multicentre, double-blind, randomised, placebo-controlled, 52-week phase II clinical trial

scientific article published on 16 December 2019

Bone marrow B-lineage cells in patients with rheumatoid arthritis following rituximab therapy

scientific article published on 30 May 2006

CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients

scientific article

CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation

scientific article published in February 2013

CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22.

scientific article published on 27 October 2017

CORRECTION

Cells of the synovium in rheumatoid arthritis. B cells

scientific article published on January 2007

Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT.

scientific article published on 3 May 2018

Combination Therapy in Rhuematoid Arthitis

scientific article published on 01 June 1995

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

scientific article published on 26 July 2004

Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration

scientific article published in January 2018

Cutting Edge: Selection of B Lymphocyte Subsets Is Regulated by Natural IgM

scientific article published on 01 December 2002

Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production

scientific article published on 13 February 2015

DNA methylation governs the dynamic regulation of inflammation by apoptotic cells during efferocytosis

scientific article

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

scholarly article

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

scientific article published on June 1999

Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies.

scientific article

Elevated serum BAFF levels are associated with rising anti-double-stranded DNA antibody levels and disease flare following B cell depletion therapy in systemic lupus erythematosus

scientific article published in October 2013

Engulfment of activated apoptotic cells abolishes TGF-β-mediated immunoregulation via the induction of IL-6.

scientific article published on 19 January 2015

Fifty years of anti-ds DNA antibodies: are we approaching journey's end?

scientific article

Germinal center B cells govern their own fate via antibody feedback

scientific article published on 18 February 2013

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting ⬇️

scientific article published on July 1, 1998

Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice

scientific article published on 01 September 1995

If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine

scientific article published on 24 September 2007

Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article published on 20 July 2009

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

scientific article published on January 2005

Increased Positive Selection of B1 Cells and Reduced B Cell Tolerance to Intracellular Antigens in c1q-Deficient Mice

scientific article published on 01 March 2007

Induced CD8+FoxP3+ Treg cells in rheumatoid arthritis are modulated by p38 phosphorylation and monocytes expressing membrane tumor necrosis factor α and CD86.

scientific article

International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease.

scientific article

Many paths lead to lupus.

scientific article

Memory in the B-cell compartment: antibody affinity maturation

scientific article

Methotrexate reduces withdrawal rates of TNF inhibitors due to ineffectiveness in rheumatoid arthritis but only in patients who are seropositive

scientific article published on 28 May 2020

Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells.

scientific article published on 4 April 2011

Monitoring and interpreting the intrinsic features of somatic hypermutation

scientific article published on 01 April 1998

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells

scientific article published on 07 March 2011

Natural serum IgM maintains immunological homeostasis and prevents autoimmunity

scientific article

Not all stoops are due to osteoporosis.

scientific article

Novel suppressive function of transitional 2 B cells in experimental arthritis

scientific article

Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophagesin vitro

scientific article published on 01 January 2005

Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis

scientific article published on 01 February 2006

Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis

scholarly article by Dao X Nguyen et al published September 2018 in The Journal of Allergy and Clinical Immunology

Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity

scientific article published on March 2011

Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis

scientific article published on 04 August 2011

Repeated B cell depletion in treatment of refractory systemic lupus erythematosus

scientific article published on 3 November 2005

Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis

scientific article published on 01 April 2008

Secreted IgM enhances B cell receptor signaling and promotes splenic but impairs peritoneal B cell survival

scientific article

Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis

scientific article published on January 2011

Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice

scientific article published on March 2009

Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis

scientific article published in August 2003

Statins for Atherosclerosis — As Good as It Gets?

scientific article published on 01 January 2005

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

scientific article

THE OCCURRENCE, NATURE AND DISTRIBUTION OF FLARES IN A COHORT OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A RHEUMATOLOGICAL VIEW

scientific article published on 01 March 1995

Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response

scientific journal article

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

scientific article published on 01 October 2012

The 'short' history of regulatory B cells

scientific article published on 03 December 2007

The BAFFling effects of rituximab in lupus: danger ahead?

scientific article published on 18 February 2016

The RA-MAP Consortium: a working model for academia-industry collaboration. ⬇️

scientific article published on 7 December 2017

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

scientific article

The efficacy of repeated treatment with B-cell depletion therapy in systemic lupus erythematosus: an evaluation

scientific article published on 12 March 2011

The impact of biological therapy on regulatory T cells in rheumatoid arthritis

scientific article

The importance of natural IgM: scavenger, protector and regulator

scientific article published on 15 October 2010

The yin and yang of regulatory T cells and inflammation in RA.

scientific article published on 31 August 2010

Therapeutic potential of Tregs to treat rheumatoid arthritis

scientific article published on June 2011

Tuberculosis and anti-TNF treatment: experience of a central London hospital

scientific article published on 23 October 2010

Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy

scientific article

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