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List of works by Claus Sorensen

A catalog of curated breast cancer genes

scientific article published on 10 November 2021

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance ⬇️

scientific article

ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function.

scientific article published on 04 April 2016

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

scientific article published on 14 February 2003

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

scientific article published on 20 June 2016

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation. ⬇️

scientific article

Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

scientific article published on 20 August 2012

Deregulation of the RB pathway in human testicular germ cell tumours ⬇️

scientific article published on June 1, 2003

E2F transcription regulation: an orphan cyclin enters the stage

scientific article published on 30 September 2019

Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave.

scientific article published in November 2015

FBH1 Catalyzes Regression of Stalled Replication Forks.

scientific article published on 10 March 2015

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

scientific article

FBH1: a new checkpoint factor.

scientific article published in August 2015

Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity ⬇️

scientific article published on January 23, 2013

Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

scientific article published on 20 August 2021

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

scientific article published in Nature Communications

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

scientific article published on 16 March 2018

Overcoming Treatment Toxicity through Sequential Therapy

scientific article published on 01 June 2019

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

scientific article published on 18 October 2018

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

scientific article

SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication

scientific article published on 28 January 2016

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation ⬇️

scientific article

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication ⬇️

scientific article published on September 21, 2011

The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis

scientific article published on 20 January 2016

The histone methyltransferase SET8 is required for S-phase progression

scientific article published on December 2007

Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains

scientific article published on 01 December 2018

miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP.

scientific article published on 13 October 2014

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis.

scientific article published in July 1999

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