List of works - Siden Top

A DFT study on the mechanism of a novel, regioselective, intramolecular N-pi rearrangement of cis and trans-eta1-N-Cp*Rh-hydroxytamoxifen complexes to their eta6 derivatives; potential breast cancer pharmaceuticals, and fluorescent probes

scientific article published on 25 February 2009

A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin

scientific article

A Novel and Mild Metal-Exchange Reaction in the Organometallic Cyclopentadienyl Series: 1,1‘-Diaryl 2-Cymantrenyl 1-Butene as an Example

scientific article published in 2000

A fast route to the potential biological reagent (η5-C5H4COOH)Re(CO)3 from [NH4] [ReO4]

A new efficient route to chiral 1,3-disubstituted ferrocenes: application to the syntheses of (R(p))- and (S(p))-17alpha-[(3'-formylferrocenyl)ethynyl]estradiol

scientific article

A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties

scientific article published on 16 November 2017

A new series of ferrocifen derivatives, bearing two aminoalkyl chains, with strong antiproliferative effects on breast cancer cells

Analyse structurale du phenyl pyruvate d'ethyle obtenu sous forme enolique par activation benzylique a l'aide de l'entite Cr(CO)3

Analytical potential of near-infrared fourier transform Raman spectra in the detection of solid transition metal carbonyl steroid hormones

Anodic properties of diarylethene derivatives having organometallic piano-stool tags

article

Antibacterial properties and mode of action of new triaryl butene citrate compounds.

scientific article

Antimicrobial, antitumor and side effects assessment of a newly synthesized tamoxifen analogue

scientific article published on 19 August 2020

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.

scientific article

Approach to ferrocenyl-podophyllotoxin analogs and their evaluation as anti-tumor agents

Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.

scientific article

Asymmetric biochemical reduction, acylation and hydrolysis in the (diene)Fe(CO)3 series: Experimental results and molecular modelling studies

article published in 1993

Asymmetric induction via co-ordination to Cr(CO)3; nucleophilic attack on acyclic carbenium ions

Atypical Lone Pair-π Interaction with Quinone Methides in a Series of Imido-Ferrociphenol Anticancer Drug Candidates

scientific article published on 14 May 2019

Atypical McMurry cross-coupling reactions leading to a new series of potent antiproliferative compounds bearing the key [ferrocenyl-ene-phenol] motif.

scientific article

Comparative Oxidative Addition of Transition-Metal Iodocyclopentadienyl Complexes (η5-C5H4-I)MLn(M = Re, Mn, Fe) with a Palladium(0) Complex: Relevance to the Efficiency of Catalytic Reactions

article

Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells

article

Cyclopentadienyl transfer reaction: thermal reaction between Re2(CO)10 and a series of cyclopentadienyl transition metal complexes

Cytotoxic triosmium carbonyl clusters: a structure-activity relationship study

scientific article published on 20 January 2014

Deciphering the activation sequence of ferrociphenol anticancer drug candidates.

scientific article published on 11 April 2012

Decomplexation of Cyclopentadienylmanganese Tricarbonyls under Very Mild Conditions: A Novel Route to Substituted Cyclopentadienes and Their Application in Organometallic Synthesis

Diastereoselectivity in the bakers yeast reduction of [1-2H](sorbaldehyde)Fe(CO)3

Direct Synthesis of Tricarbonyl(cyclopentadienyl)rhenium and Tricarbonyl(cyclopentadienyl)technetium Units from Ferrocenyl Moieties− Preparation of 17α-Ethynylestradiol Derivatives Bearing a Tricarbonyl(cyclopentadienyl)technetium Group

scholarly article by Stéphane Masi et al published May 2004 in European Journal of Inorganic Chemistry

Effect of the amino chain length and the transformation into citric acid salts of aryl-diphenyl-butenes and ferrocenyl-diphenyl-butenes bearing two dimethylaminoalkyl chains on their antimicrobial activities.

scientific article published on 4 October 2013

Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infections

article

Efficient new constructs against triple negative breast cancer cells: synthesis and preliminary biological study of ferrocifen-SAHA hybrids and related species.

scientific article published on November 2013

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

scientific article published on 28 October 2014

Facile route to ferrocifen, 1-[4-(2-dimethylaminoethoxy)]-1-(phenyl-2-ferrocenyl-but-1-ene), first organometallic analogue of tamoxifen, by the McMurry reaction

article by Siden Top et al published August 1997 in Journal of Organometallic Chemistry

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

scientific article

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells.

scientific article published on 17 May 2012

Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

scientific article published on January 2009

Ferrocifen derivatives that induce senescence in cancer cells: selected examples

scientific article published on 6 September 2014

Ferrocifen type anti cancer drugs

scientific article

Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells

scientific article published on 01 July 2018

First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

scholarly article by Gérard Jaouen et al published 2001 in Chemical Communications

First attachment of the stable organometallic moiety 〚Re(CO) 3 (η 5 -C 5 H 4 –C≡C–)〛 at position 11ß of oestradiol. Biochemical behaviour of the complex

Formation de liaison CC par couplage réducteur d'ions carbéniums arène chrome tricarbonyle

Intracellular Localization of an Osmocenyl-Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X-ray Fluorescence Nanoimaging

scientific article published on 06 February 2019

Introduction of a planar chirality onto steroid substrates: synthesis of (S) and (R)-2′-formylcymantrenyl-17α-ethynylestradiols using (S) and (R)-1-formyl-2-iodo-cymantrenes

Isolation of fac-[Re(CO)3(HMPA)3][BF4]. Structural characterization of a key cationic intermediate in the exchange reaction between [Re(CO)6][BF4] and acetylferrocene. Implications in radiopharmaceutical chemistry

Les ions α-carbéniums benchrotréniques: mode de génération, exemples d'utilisation a la préparation d'amines, d'éthers et au contrôle stéréochimique lors d'attaques nucléophiles

Metal carbonyl fragments as a new class of markers in molecular biology

scholarly article by Gerard Jaouen published in August 1985

Metal complex SERMs (selective oestrogen receptor modulators). The influence of different metal units on breast cancer cell antiproliferative effects

scientific article

Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro

scientific article published on June 2005

Molecular recognition using bioorganometallic probes: NMR, x-ray crystallographic, and molecular modeling study of the conformations of chromium tricarbonyl derivatives of hexestrol and their relevance to estradiol-receptor binding

N-alkylation of nitriles with tricarbonylchromium complexes of benzyl and related alcohols as synthetic intermediates. Further development of the Ritter reactions

article

Nanoparticles loaded with ferrocenyl tamoxifen derivatives for breast cancer treatment

scientific article

New Ortho-Directing Group for Lithiation: Use of a Methoxy−Imino Auxiliary for the Synthesis of Chiral Ortho-Substituted Acetyl- and Propionylferrocenes

New Synthetic Pathways ofcis- ortrans-Hydroxytamoxifen Derivatives with in Situ Formed [Cp*Rh(solvent)3]2+Complexes: Kinetic and Thermodynamic Control, Including a Novel, Intramolecular N-π Rearrangement, and Relative Binding Affinities of the η6Co

New and efficient routes to CpRe(CO)3 substituted steroids

New and efficient synthesis of CpRe(CO)3 substituted steroids

New paradigms for synthetic pathways inspired by bioorganometallic chemistry

Novel estradiol derivatives labeled with Ru, W, and Co complexes. Influence on hormone-receptor affinity of several organometallic groups at the 17 alpha position

scientific article

Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides

scientific article published on 14 July 2015

Organometallic analogues of tamoxifen: Effect of the amino side-chain replacement by a carbonyl ferrocenyl moiety in hydroxytamoxifen

Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay

Organometallic cyclic polyphenols derived from 1,2-(alpha-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells.

scientific article published on 8 July 2010

Organometallic diphenols: The importance of the organometallic moiety on the expression of a cytotoxic effect on breast cancer cells

Organometallics as Potential Protein Labels: Pyrylium and Pyridinium Salts Bearing (C6H5)Cr(CO)3, (C5H4)Mn(CO)3, and Ferrocenyl Substituents

Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells.

scientific article published on 13 April 2016

Oxidative Sequence of a Ruthenocene-Based Anticancer Drug Candidate in a Basic Environment

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

scientific article published on 16 April 2015

Pressure-tuning infrared and solution Raman spectroscopic studies of 17β-estradiol and several A-ring and 17α-ethynylestradiol derivatives

Pro-oxidant properties of AZT and other thymidine analogues in macrophages: implication of the azido moiety in oxidative stress

scientific article

Protonation of chromium tricarbonyl complexes of triphenylsilanol and triphenylcarbinol: synthetic, x-ray crystallographic, and NMR study of (Ph3SiOH)[Cr(CO)3]n (n = 1-3) and of (Ph3COH)Cr(CO)3

Rapid and mild synthesis of [Re2(CO)10] by reduction of [NH4][ReO4] at atmospheric CO pressure

Reaction of [Re(CO)6]+ cation with cyclopentadienylthallium derivatives. Formation of cyclopentadienylrheniumtricarbonyl derivatives via [Re(CO)3L3]+ (L=solvent)

Reactions of eq,eq-Re2(CO)8(MeCN)2 with phenylacetylene and α-ethynylestradiol. A new synthesis of acetylide complexes

Reactions of superoxide ion with hydrocarbons activated by the tricarbonylchromium unit

Reactivity and reaction pathways of electrochemically generated 17-electron tricarbonyl steroid chromium cations

Regiospecific and stereospecific functionalization of benzylic sites by tricarbonylchromium arene complexation

scientific article published in 1984

Rhenium Carbonyl Complexes of .beta.-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals

scholarly article by Siden Top et al published August 1995 in Journal of the American Chemical Society

Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds

scientific article

Rotational barriers in diphenylmethyl anions stabilized by trimethylsilyl and tricarbonylchromium(0) moieties

scientific article published in 1983

Selection of a suitable disc bioassay for the screening of anti-tumor molecules

scientific article published on December 2013

Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior.

scientific article

Selective estrogen-receptor modulators (SERMs) in the cyclopentadienylrhenium tricarbonyl series: synthesis and biological behaviour.

scientific article

Selective functionalization of crown ethers via arene chromium tricarbonyl complexes

Small Structural Differences between Two Ferrocenyl Diphenols Determine Large Discrepancies of Reactivity and Biological Effects

scientific article published on 24 September 2019

Stereospecific 6-alkylation of oestradiol derivatives via Cr(CO)3 complexes

Stopping a chromium carousel: X-ray crystallographic and variable-temperature13C n. m. r. studies on dicarbonyl(hexaethylbenzene)-thiocarbonylchromium(0) and related complexes

article published in 1983

Studies on organometallic selective estrogen receptor modulators. (SERMs) Dual activity in the hydroxy-ferrocifen series

Substituent effects in benzylic functionalization of arene(tricarbonyl) chromium complexes

Surface grafting of a π-conjugated amino-ferrocifen drug

Synthesis and Antiproliferative Effects of [3]Ferrocenophane Transposition Products and Pinacols Obtained from McMurry Cross-Coupling Reactions

Synthesis and Structure Activity Relationship of Organometallic Steroidal Androgen Derivatives

Synthesis and antiproliferative activity of (Z + E)-1-[4-(2-(cyclopentadienyltricarbonylmanganese)-2-oxo-ethoxy)phenyl]-1,2-di(p-hydroxyphenyl)-but-1-ene against breast cancer cells

Synthesis and antiproliferative activity of hydroxyferrocifen hybrids against triple-negative breast cancer cells

scientific article

Synthesis and antiproliferative evaluation of ferrocenyl and cymantrenyl triaryl butene on breast cancer cells. Biodistribution study of the corresponding technetium-99m tamoxifen conjugate

Synthesis and biodistribution of [99mTc]-N-[4-nitro-3-trifluoromethyl-phenyl] cyclopentadienyltricarbonyltechnetium carboxamide, a nonsteroidal antiandrogen flutamide derivative

scientific article published on 12 February 2010

Synthesis and biological activity of ferrocenyl derivatives of the non-steroidal antiandrogens flutamide and bicalutamide

Synthesis and characterization of new ferrocenyl compounds with different alkyl chain lengths and functional groups to target breast cancer cells

Synthesis and structure-activity relationships of ferrocenyl tamoxifen derivatives with modified side chains

scientific article

Synthesis and structure-activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide

scientific article

Synthesis of Optically Pureo-Formylcyclopentadienyl Metal Complexes of 17α-Ethynylestradiol. Recognition of the Planar Chirality by the Estrogen Receptor

Synthesis of cyclopentadienyltricarbonylrhenium(I) carboxylic acid from perrhenate

Synthesis of ethyl phenylpyruvate and related compounds using chromium tricarbonyl complexes

Synthesis of tritium-labeled (3)-O-(3-hydroxypropyl)-17α-estradiol chromium tricarbonyl: The first radioactive transition metal carbonyl steroid hormone

Synthesis, Characterization, and Antiproliferative Activities of Novel Ferrocenophanic Suberamides against Human Triple-Negative MDA-MB-231 and Hormone-Dependent MCF-7 Breast Cancer Cells

Synthesis, Characterization, and Biological Properties of Osmium-Based Tamoxifen Derivatives - Comparison with Their Homologues in the Iron and Ruthenium Series

scholarly article by Hui Zhi Shirley Lee et al published 11 August 2015 in European Journal of Inorganic Chemistry

Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone

scientific article

Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3]ferrocenophane tetrasubstituted olefin derivatives against human cancer cells

scientific article published on December 2010

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

scientific article

Synthetic and mechanistic pathways of cis and trans-hydroxytamoxifen drug derivatives reacting with Cp*Rh complexes that involve η1-N, η2-N,O, η1-O, and η6 bonding modes, via a novel N-π rearrangement; relative binding affinities and computer dockin

scientific article published on December 2010

Synthetic strategy for organometallic complexes of rhenium with exceptionally high affinity for the oestradiol receptor; their potential use as imaging and therapeutic agents

scholarly article by Siden Top et al published 1994 in Journal of the Chemical Society. Chemical communications

Synthetic, structural, and reactivity studies of dirhenium carbonyl complexes of 17.alpha.-ethynylestradiol and phenylacetylene: variable-temperature carbon-13 NMR spectra and x-ray crystal structure of (.mu.-H)(.mu.-C.tplbond.C-R)Re2(CO)7(MeCN)

Tamoxifen derivatives for delivery of the antitumoral (DACH)Pt group: selective synthesis by McMurry coupling, and biochemical behaviour

scientific article published in August 2003

Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells.

scientific article

The effect of protic electron donor aromatic substituents on ferrocenic and [3]ferrocenophanic anilines and anilides: Some aspects of structure–activity relationship studies on organometallic compounds with strong antiproliferative effects

The first organometallic selective estrogen receptor modulators (SERMs) and their relevance to breast cancer

scientific article published in September 2004

The length of the bridging chain in ansa-metallocenes influences their antiproliferative activity against triple negative breast cancer cells (TNBC)

scientific article published on 01 August 2016

The presence of a ferrocenyl unit on an estrogenic molecule is not always sufficient to generate in vitro cytotoxicity.

scientific article published on November 2006

The replacement of a phenol group by an aniline or acetanilide group enhances the cytotoxicity of 2-ferrocenyl-1,1-diphenyl-but-l-ene compounds against breast cancer cells

The use of tricarbonyl chromium hexestrol derivatives in the detection of oestradiol receptor sites

Transition-metal carbonyl complexes in progesterone receptor assay

Vibrational spectra of the organometallic estrogen-receptor marker [3-O-(3-hydroxypropyl)-17β-estradiol]-α-tricarbonylchromium(0) and related compounds

List of works by Siden Top

A DFT study on the mechanism of a novel, regioselective, intramolecular N-pi rearrangement of cis and trans-eta1-N-Cp*Rh-hydroxytamoxifen complexes to their eta6 derivatives; potential breast cancer pharmaceuticals, and fluorescent probes

A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin

A Novel and Mild Metal-Exchange Reaction in the Organometallic Cyclopentadienyl Series: 1,1‘-Diaryl 2-Cymantrenyl 1-Butene as an Example

A fast route to the potential biological reagent (η5-C5H4COOH)Re(CO)3 from [NH4] [ReO4]

A new efficient route to chiral 1,3-disubstituted ferrocenes: application to the syntheses of (R(p))- and (S(p))-17alpha-[(3'-formylferrocenyl)ethynyl]estradiol

A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties

A new series of ferrocifen derivatives, bearing two aminoalkyl chains, with strong antiproliferative effects on breast cancer cells

Analyse structurale du phenyl pyruvate d'ethyle obtenu sous forme enolique par activation benzylique a l'aide de l'entite Cr(CO)3

Analytical potential of near-infrared fourier transform Raman spectra in the detection of solid transition metal carbonyl steroid hormones

Anodic properties of diarylethene derivatives having organometallic piano-stool tags

Antibacterial properties and mode of action of new triaryl butene citrate compounds.

Antimicrobial, antitumor and side effects assessment of a newly synthesized tamoxifen analogue

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.

Approach to ferrocenyl-podophyllotoxin analogs and their evaluation as anti-tumor agents

Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.

Asymmetric biochemical reduction, acylation and hydrolysis in the (diene)Fe(CO)3 series: Experimental results and molecular modelling studies

Asymmetric induction via co-ordination to Cr(CO)3; nucleophilic attack on acyclic carbenium ions

Atypical Lone Pair-π Interaction with Quinone Methides in a Series of Imido-Ferrociphenol Anticancer Drug Candidates

Atypical McMurry cross-coupling reactions leading to a new series of potent antiproliferative compounds bearing the key [ferrocenyl-ene-phenol] motif.

Comparative Oxidative Addition of Transition-Metal Iodocyclopentadienyl Complexes (η5-C5H4-I)MLn(M = Re, Mn, Fe) with a Palladium(0) Complex: Relevance to the Efficiency of Catalytic Reactions

Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells

Cyclopentadienyl transfer reaction: thermal reaction between Re2(CO)10 and a series of cyclopentadienyl transition metal complexes

Cytotoxic triosmium carbonyl clusters: a structure-activity relationship study

Deciphering the activation sequence of ferrociphenol anticancer drug candidates.

Decomplexation of Cyclopentadienylmanganese Tricarbonyls under Very Mild Conditions: A Novel Route to Substituted Cyclopentadienes and Their Application in Organometallic Synthesis

Diastereoselectivity in the bakers yeast reduction of [1-2H](sorbaldehyde)Fe(CO)3

Direct Synthesis of Tricarbonyl(cyclopentadienyl)rhenium and Tricarbonyl(cyclopentadienyl)technetium Units from Ferrocenyl Moieties− Preparation of 17α-Ethynylestradiol Derivatives Bearing a Tricarbonyl(cyclopentadienyl)technetium Group

Effect of the amino chain length and the transformation into citric acid salts of aryl-diphenyl-butenes and ferrocenyl-diphenyl-butenes bearing two dimethylaminoalkyl chains on their antimicrobial activities.

Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infections

Efficient new constructs against triple negative breast cancer cells: synthesis and preliminary biological study of ferrocifen-SAHA hybrids and related species.

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

Facile route to ferrocifen, 1-[4-(2-dimethylaminoethoxy)]-1-(phenyl-2-ferrocenyl-but-1-ene), first organometallic analogue of tamoxifen, by the McMurry reaction

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells.

Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

Ferrocifen derivatives that induce senescence in cancer cells: selected examples

Ferrocifen type anti cancer drugs

Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells

First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

First attachment of the stable organometallic moiety 〚Re(CO) 3 (η 5 -C 5 H 4 –C≡C–)〛 at position 11ß of oestradiol. Biochemical behaviour of the complex

Formation de liaison CC par couplage réducteur d'ions carbéniums arène chrome tricarbonyle

Intracellular Localization of an Osmocenyl-Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X-ray Fluorescence Nanoimaging

Introduction of a planar chirality onto steroid substrates: synthesis of (S) and (R)-2′-formylcymantrenyl-17α-ethynylestradiols using (S) and (R)-1-formyl-2-iodo-cymantrenes

Isolation of fac-[Re(CO)3(HMPA)3][BF4]. Structural characterization of a key cationic intermediate in the exchange reaction between [Re(CO)6][BF4] and acetylferrocene. Implications in radiopharmaceutical chemistry

Les ions α-carbéniums benchrotréniques: mode de génération, exemples d'utilisation a la préparation d'amines, d'éthers et au contrôle stéréochimique lors d'attaques nucléophiles

Metal carbonyl fragments as a new class of markers in molecular biology

Metal complex SERMs (selective oestrogen receptor modulators). The influence of different metal units on breast cancer cell antiproliferative effects

Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro

Molecular recognition using bioorganometallic probes: NMR, x-ray crystallographic, and molecular modeling study of the conformations of chromium tricarbonyl derivatives of hexestrol and their relevance to estradiol-receptor binding

N-alkylation of nitriles with tricarbonylchromium complexes of benzyl and related alcohols as synthetic intermediates. Further development of the Ritter reactions

Nanoparticles loaded with ferrocenyl tamoxifen derivatives for breast cancer treatment

New Ortho-Directing Group for Lithiation: Use of a Methoxy−Imino Auxiliary for the Synthesis of Chiral Ortho-Substituted Acetyl- and Propionylferrocenes

New Synthetic Pathways ofcis- ortrans-Hydroxytamoxifen Derivatives with in Situ Formed [Cp*Rh(solvent)3]2+Complexes: Kinetic and Thermodynamic Control, Including a Novel, Intramolecular N-π Rearrangement, and Relative Binding Affinities of the η6Co

New and efficient routes to CpRe(CO)3 substituted steroids

New and efficient synthesis of CpRe(CO)3 substituted steroids

New paradigms for synthetic pathways inspired by bioorganometallic chemistry

Novel estradiol derivatives labeled with Ru, W, and Co complexes. Influence on hormone-receptor affinity of several organometallic groups at the 17 alpha position

Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides

Organometallic analogues of tamoxifen: Effect of the amino side-chain replacement by a carbonyl ferrocenyl moiety in hydroxytamoxifen

Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay

Organometallic cyclic polyphenols derived from 1,2-(alpha-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells.

Organometallic diphenols: The importance of the organometallic moiety on the expression of a cytotoxic effect on breast cancer cells

Organometallics as Potential Protein Labels: Pyrylium and Pyridinium Salts Bearing (C6H5)Cr(CO)3, (C5H4)Mn(CO)3, and Ferrocenyl Substituents

Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells.

Oxidative Sequence of a Ruthenocene-Based Anticancer Drug Candidate in a Basic Environment

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

Pressure-tuning infrared and solution Raman spectroscopic studies of 17β-estradiol and several A-ring and 17α-ethynylestradiol derivatives

Pro-oxidant properties of AZT and other thymidine analogues in macrophages: implication of the azido moiety in oxidative stress

Protonation of chromium tricarbonyl complexes of triphenylsilanol and triphenylcarbinol: synthetic, x-ray crystallographic, and NMR study of (Ph3SiOH)[Cr(CO)3]n (n = 1-3) and of (Ph3COH)Cr(CO)3

Rapid and mild synthesis of [Re2(CO)10] by reduction of [NH4][ReO4] at atmospheric CO pressure

Reaction of [Re(CO)6]+ cation with cyclopentadienylthallium derivatives. Formation of cyclopentadienylrheniumtricarbonyl derivatives via [Re(CO)3L3]+ (L=solvent)

Reactions of eq,eq-Re2(CO)8(MeCN)2 with phenylacetylene and α-ethynylestradiol. A new synthesis of acetylide complexes

Reactions of superoxide ion with hydrocarbons activated by the tricarbonylchromium unit

Reactivity and reaction pathways of electrochemically generated 17-electron tricarbonyl steroid chromium cations