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List of works by Karl F Hoffmann

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IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis

scientific article published on 01 June 2000
IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.

scientific article published on March 2002
Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family.

scientific article
Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

scientific article
Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni.

scientific article published on 9 August 2011
Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases.

scientific article
Immunopathology of schistosomiasis mansoni in mice and men

scientific article published on 01 September 2000
Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

scientific article published on 5 October 2015
Gender-associated gene expression in two related strains of Schistosoma japonicum.

scientific article published on August 2004
Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing.

scientific article
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni

scientific article
Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions.

scientific article published on 17 September 2001
Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling

scientific article
Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.

scientific article published in November 2005
Glycomics-driven discoveries in schistosome research.

scientific article published on 17 June 2007
Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

scientific article published on 16 May 2017
Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.

scientific article
Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E

scientific article
Platyhelminth Venom Allergen-Like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum.

scientific article
Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.

scientific article
IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12

scientific article published on 01 October 1998
Molecular characterization of a 20.8-kDa Schistosoma mansoni antigen. Sequence similarity to tegumental associated antigens and dynein light chains.

scientific article published on June 1997
Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel

scientific article published in May 2006
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes.

scientific article
Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo.

scientific article
Medicine. Halting harmful helminths.

scientific article published on October 2014
Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae.

scientific article
Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion.

scientific article published on 22 October 2012
Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype

scientific article published on 01 June 2011
Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

scientific article published on 21 May 2018
Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7

scientific article (publication date: March 2015)
The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica

scientific article
(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

scientific article published on 28 December 2016
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.

scientific article published on 06 August 2008
Epigenetics: A key regulator of platyhelminth developmental biology?

scientific article published on February 17, 2012
Programmed genome editing of the omega-1 ribonuclease of the blood fluke,

scientific article published on 15 January 2019
The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

scientific article
Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

scientific article published on 17 April 2018
Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

scientific article published on 6 July 2015
Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

scientific article published on 13 November 2018
Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis

scientific article
Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

scientific article
Characterization of the Schistosoma transcriptome opens up the world of helminth genomics

scientific article published in 2003
The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

scientific article published in April 2018
Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense.

scientific article published on 5 June 2017
An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

scientific article published on 26 October 2018
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

scientific article published on 15 November 2019
Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

scientific article published on 14 August 2017
DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells

scientific article published on 30 April 2020
DISMISS: detection of stranded methylation in MeDIP-Seq data

scientific article

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