List of works - Karl F Hoffmann

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

scientific article published on 28 December 2016

An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

scientific article published on 26 October 2018

Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

scientific article

Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation, and Untargeted Metabolomics

scientific article published on 28 May 2019

Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni

scientific article

Characterization of the Schistosoma transcriptome opens up the world of helminth genomics

scientific article published in 2003

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes ⬇️

scientific article published on 30 March 2023

Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E

scientific article

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

scientific article published on 13 November 2018

Corrigendum to 'the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities' [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213-222]

scientific article published on 17 July 2018

Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype

scientific article published on 01 June 2011

Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis

scientific article

Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes.

scientific article

Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni.

scientific article published on 9 August 2011

DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells

scientific article published on 30 April 2020

DISMISS: detection of stranded methylation in MeDIP-Seq data

scientific article

Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

scientific article published on 17 April 2018

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family.

scientific article

Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing.

scientific article

Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions.

scientific article published on 17 September 2001

Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7

scientific article (publication date: March 2015)

Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel

scientific article published in May 2006

Epigenetics: A key regulator of platyhelminth developmental biology? ⬇️

scientific article published on February 17, 2012

Erratum to 'Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni' [IJP Drugs Drug Resist. 8 (2018) 559-570]

scientific article published on 02 July 2019

Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.

scientific article

Gender-associated gene expression in two related strains of Schistosoma japonicum.

scientific article published on August 2004

Glycomics-driven discoveries in schistosome research.

scientific article published on 17 June 2007

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni.

scientific article published on 21 May 2018

Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.

scientific article

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

scientific article published on 6 July 2015

IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12

scientific article published on 01 October 1998

IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis

scientific article published on 01 June 2000

IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.

scientific article published on March 2002

Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling

scientific article

Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature

scientific article published on 19 July 2022

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni

scientific article published on 18 February 2021

Immunopathology of schistosomiasis mansoni in mice and men

scientific article published on 01 September 2000

Medicine. Halting harmful helminths.

scientific article published on October 2014

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

scientific article

Molecular characterization of a 20.8-kDa Schistosoma mansoni antigen. Sequence similarity to tegumental associated antigens and dynein light chains.

scientific article published on June 1997

Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.

scientific article published in November 2005

Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense.

scientific article published on 5 June 2017

Parasite genomics and post-genomic activities: 21st century resources for the parasite immunologist

scientific article published on 01 February 2012

Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo.

scientific article

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout <i>Schistosoma mansoni</i> Infection

scientific article published on 30 August 2021

Platyhelminth Venom Allergen-Like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum.

scientific article

Programmed genome editing of the omega-1 ribonuclease of the blood fluke,

scientific article published on 15 January 2019

Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

scientific article published on 5 October 2015

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

scientific article published on 19 October 2020

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

scientific article published on 14 August 2017

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

scientific article published in 2021

Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.

scientific article published on 06 August 2008

Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion.

scientific article published on 22 October 2012

Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

scientific article published on 25 May 2019

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

scientific article published on 13 January 2022

Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases.

scientific article

Schistosome genomics and beyond: news and views

scientific article published on 08 September 2007

The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation

scientific article published on 25 June 2019

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

scientific article

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

scientific article published in April 2018

The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica

scientific article

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

scientific article published on 15 November 2019

Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae.

scientific article

Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

scientific article published on 16 May 2017

List of works by Karl F Hoffmann

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation, and Untargeted Metabolomics

Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni

Characterization of the Schistosoma transcriptome opens up the world of helminth genomics

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes ⬇️

Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Corrigendum to 'the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities' [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213-222]

Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype

Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis

Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes.

Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni.

DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells

DISMISS: detection of stranded methylation in MeDIP-Seq data

Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family.

Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing.

Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions.

Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7

Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel

Epigenetics: A key regulator of platyhelminth developmental biology? ⬇️

Erratum to 'Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni' [IJP Drugs Drug Resist. 8 (2018) 559-570]

Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.

Gender-associated gene expression in two related strains of Schistosoma japonicum.

Glycomics-driven discoveries in schistosome research.

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni.

Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12

IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis

IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.

Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling

Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni

Immunopathology of schistosomiasis mansoni in mice and men

Medicine. Halting harmful helminths.

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

Molecular characterization of a 20.8-kDa Schistosoma mansoni antigen. Sequence similarity to tegumental associated antigens and dynein light chains.

Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.

Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense.

Parasite genomics and post-genomic activities: 21st century resources for the parasite immunologist

Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo.

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout <i>Schistosoma mansoni</i> Infection

Platyhelminth Venom Allergen-Like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum.

Programmed genome editing of the omega-1 ribonuclease of the blood fluke,

Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.

Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion.

Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases.

Schistosome genomics and beyond: news and views

The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae.

Whole genome analysis of a schistosomiasis-transmitting freshwater snail.