List of works - M. Matilde Marques

2'-Deoxythymidine adducts from the anti-HIV drug nevirapine.

scientific article

32P-Postlabeling ofN-(Deoxyguanosin-8-yl)arylamine Adducts: A Comparative Study of Labeling Efficiencies

scientific article published on 01 July 1999

A review of human carcinogens—Part A: pharmaceuticals

article

Acetaminophen Induces an Antioxidative Response in Lettuce Plants

scientific article published in 2021

Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity.

scientific article published in May 2010

Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling.

scientific article

Arylamine–DNA adduct conformation in relation to mutagenesis

article

Bioactivation to an aldehyde metabolite--possible role in the onset of toxicity induced by the anti-HIV drug abacavir

scientific article

Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz

scientific article published on 08 May 2012

Bitumens and bitumen emissions, and some heterocyclic polycyclic aromatic hydrocarbons

article

Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure

scientific article published on 28 September 2015

Carcinogenicity of some drugs and herbal products

article

Characterization of the Major DNA Adduct Formed by α-Hydroxy-N-desmethyltamoxifen in Vitro and in Vivo

scientific article published on 01 March 2000

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.

scientific article published in May 2009

DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.

scientific article published in October 2003

DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.

scientific article published on 30 January 2007

DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol.

scientific article

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions.

scientific article published on 19 September 2013

Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry.

scientific article

Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients.

scientific article published on 16 August 2016

Effect of substituents in the molecular and supramolecular architectures of 1-ferrocenyl-2-(aryl)thioethanones

scientific article published in 2015

Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts.

scientific article published in November 1997

Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity ⬇️

scientific article published on June 28, 2012

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study.

scientific article published on 14 July 2016

High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches

scientific article published on 25 March 2018

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.

scientific article published in October 1997

Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.

scientific article published on 18 November 2016

Molecular recognition of guanosine and 2-acetylaminofluorene-modified guanosine. A comparative study

Mutations induced by aromatic amine DNA adducts in pBR322.

scientific article

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model

scientific article published on 03 June 2020

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach

scientific article published on 24 November 2015

New Syntheses of DNA Adducts from Methylated Anilines Present in Tobacco Smoke

scientific article published on 01 December 1999

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

scientific article published on 4 November 2016

N‐terminal valine adduct from the anti‐HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo ⬇️

scientific article published on November 1, 2012

One-dimensional multiple quantum filtration1H NMR spectra of a 15-mer DNA Duplex modified by the carcinogen 4-aminobiphenyl

article published in 1993

Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

article

Protein adducts as prospective biomarkers of nevirapine toxicity.

scientific article

Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.

scientific article published in March 2003

Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLCES-MS

scientific article published on 01 June 1999

Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts

Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity

scientific article published on 11 November 2011

Sex differences in apolipoprotein A1 and nevirapine-induced toxicity.

scientific article

Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats.

scientific article published on 27 March 2015

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity

scientific article published on 01 February 2019

Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid.

scientific article published on January 2004

Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.

scientific article published on 3 July 2008

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

scientific article published on 12 June 2013

Synthesis and investigation of alpha-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen.

scientific article published in September 2003

Synthesis, Characterization, and Quantitation of a 4-Aminobiphenyl−DNA Adduct Standard

scientific article published on 01 January 1999

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors

scientific article published on 21 June 2019

Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts.

scientific article published in February 2001

Tamoxifen-DNA adduct formation in human endometrium.

scientific article published in October 2005

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals

article

The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Frémy's salt

scientific article published on 31 December 2013

The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: a nuclear magnetic resonance study.

scientific article published on September 2013

Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics

scientific article published on 01 January 2019

List of works by M. Matilde Marques

2'-Deoxythymidine adducts from the anti-HIV drug nevirapine.

32P-Postlabeling ofN-(Deoxyguanosin-8-yl)arylamine Adducts: A Comparative Study of Labeling Efficiencies

A review of human carcinogens—Part A: pharmaceuticals

Acetaminophen Induces an Antioxidative Response in Lettuce Plants

Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity.

Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling.

Arylamine–DNA adduct conformation in relation to mutagenesis

Bioactivation to an aldehyde metabolite--possible role in the onset of toxicity induced by the anti-HIV drug abacavir

Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz

Bitumens and bitumen emissions, and some heterocyclic polycyclic aromatic hydrocarbons

Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure

Carcinogenicity of some drugs and herbal products

Characterization of the Major DNA Adduct Formed by α-Hydroxy-N-desmethyltamoxifen in Vitro and in Vivo

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.

DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.

DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.

DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol.

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions.

Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry.

Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients.

Effect of substituents in the molecular and supramolecular architectures of 1-ferrocenyl-2-(aryl)thioethanones

Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts.

Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity ⬇️

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study.

High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.

Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.

Molecular recognition of guanosine and 2-acetylaminofluorene-modified guanosine. A comparative study

Mutations induced by aromatic amine DNA adducts in pBR322.

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach

New Syntheses of DNA Adducts from Methylated Anilines Present in Tobacco Smoke

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

N‐terminal valine adduct from the anti‐HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo ⬇️

One-dimensional multiple quantum filtration1H NMR spectra of a 15-mer DNA Duplex modified by the carcinogen 4-aminobiphenyl

Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

Protein adducts as prospective biomarkers of nevirapine toxicity.

Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.

Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLCES-MS

Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts

Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity

Sex differences in apolipoprotein A1 and nevirapine-induced toxicity.

Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats.

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity

Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid.

Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

Synthesis and investigation of alpha-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen.

Synthesis, Characterization, and Quantitation of a 4-Aminobiphenyl−DNA Adduct Standard

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors

Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts.

Tamoxifen-DNA adduct formation in human endometrium.

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals

The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Frémy's salt

The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: a nuclear magnetic resonance study.

Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics