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Authors whose works are in public domain in at least one jurisdiction

List of works by Manuel Serrano Marugán

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The hallmarks of aging

scientific article
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

scientific article
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

scientific article
Tumour biology: senescence in premalignant tumours

scientific article published on August 2005
Role of the INK4a locus in tumor suppression and cell mortality

scientific article
Cellular senescence in cancer and aging

scientific article
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

scientific article (publication date: 27 August 2009)
The Ink4/Arf locus is a barrier for iPS cell reprogramming

scientific article (publication date: 27 August 2009)
Cellular senescence: from physiology to pathology

scientific article
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

scientific article published on October 1, 1998
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

scientific article
Sirt1 protects against high-fat diet-induced metabolic damage

scholarly article
p19ARF links the tumour suppressor p53 to Ras

scientific article published in Nature
The common biology of cancer and ageing

scientific article published on August 2007
Programmed cell senescence during mammalian embryonic development

scientific article published on 14 November 2013
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

scientific article published on August 2003
Mutations and altered expression of p16INK4 in human cancer.

scientific article published in November 1994
Delayed ageing through damage protection by the Arf/p53 pathway

scientific article published in Nature
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

scientific article published on 12 April 2010
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

scientific article
Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells

scientific article
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

scientific article published on June 2011
Putting the stress on senescence

scientific article
The power and the promise of oncogene-induced senescence markers

scientific article
Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

scientific article published in January 1995
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

scientific article
Telomerase reverse transcriptase delays aging in cancer-resistant mice

scientific article
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

scientific article
Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

scientific article
Tumor suppressors and oncogenes in cellular senescence.

scientific article
p53: guardian of the genome and policeman of the oncogenes.

scientific article published on 28 May 2007
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis

scientific article published in February 2004
SIRT1: recent lessons from mouse models.

scientific article published on 24 November 2010
GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.

scientific article published on 10 June 2014
Pten positively regulates brown adipose function, energy expenditure, and longevity

scientific article
Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

scientific article published in Journal of Biological Chemistry
The tumor suppressor protein p16INK4a.

scientific article published on November 1997
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

scientific article
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

scientific article published on September 1999
SIRT1 contributes to telomere maintenance and augments global homologous recombination

scientific article
Oncogenicity of the developmental transcription factor Sox9.

scientific article
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

scientific article
Mutations associated with familial melanoma impair p16INK4 function

scientific article published in May 1995
Histone macroH2A isoforms predict the risk of lung cancer recurrence

scientific article published on 03 August 2009
Cancer and ageing: convergent and divergent mechanisms

scientific article published on September 2007
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

scientific article
The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

scientific article published in February 2000
Deletion of the p16 and p15 Genes in Human Bladder Tumors

article
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.

scientific article
Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

scientific article

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