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List of works by Burkhard Kleuser

17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30.

scientific article published on 3 September 2008

17-Beta-estradiol inhibits transforming-growth-factor-beta-induced MCF-7 cell migration by Smad3-repression

scientific article published on 23 February 2006

A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells

scientific article published on April 2016

A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging

scientific article

A sphingolipid mechanism for behavioral extinction

scientific article published on 20 January 2016

Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation

scientific article published on January 2017

Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity

scientific article published on 22 August 2019

Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis

scientific article

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets

scientific article published on 10 March 2017

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

scientific article (publication date: 16 June 2013)

Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients

scientific article published on 17 August 2015

Analysis of Genomic DNA Methylation Levels in Human Placenta using Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry

scientific article published in 2014

Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes

scientific article published in August 2003

Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction

scientific article published on 16 October 2013

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

scientific article

Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin

scientific article

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

scientific article

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes

scientific article

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation

Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin

scientific article published on 3 February 2018

Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake

scientific article published on 20 March 2007

Decreased plasma levels of the endothelial protective sphingosine-1-phosphate are associated with dengue-induced plasma leakage

scientific article published on 13 July 2015

Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

scientific article published on 05 August 2019

Dexamethasone protects human fibroblasts from apoptosis via an S1P3-receptor subtype dependent activation of PKB/Akt and Bcl XL.

scientific article published on 18 December 2009

Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease ⬇️

scientific article published on 3 March 2018

Divergent role of sphingosine 1-phosphate on insulin resistance

scientific article published on 16 June 2014

Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues

scientific article published on 21 December 2012

Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice

scientific article published on 2 November 2014

Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in Non-Small Cell Lung Carcinoma

scientific article published on 7 September 2017

Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital

scientific article published on 6 December 2014

Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers

scientific article published on 6 July 2016

Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells

scientific article published on 18 May 2010

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells

scientific article published on 7 May 2013

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

scientific article published on 29 January 2018

Formulation and comparative in vitro evaluation of various dexamethasone-loaded pH-sensitive polymeric nanoparticles intended for dermal applications

scientific article

Formulation and in vitro evaluation of polymeric enteric nanoparticles as dermal carriers with pH-dependent targeting potential

scientific article published on 5 July 2016

Glucocorticoid receptor interactions with glucocorticoids: evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants

scientific article

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.

scientific article

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate

scientific article published on 5 August 2015

Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans.

scientific article

How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?

scientific article published on 22 September 2017

Human polymerase alpha inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives

scientific article published on April 2010

Hypermethylation of ITGA4, TFPI2 and VIMENTIN promoters is increased in inflamed colon tissue: putative risk markers for colitis-associated cancer

scientific article published on 23 April 2015

Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling

scientific article published on January 2007

Influences of opioids and nanoparticles on in vitro wound healing models

scientific article published on April 2009

Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells

scientific article

Internal threshold of toxicological concern values: enabling route-to-route extrapolation

scientific article published on 12 June 2014

Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes

scientific article

Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease

scientific article published on 23 December 2016

Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype

scientific article published on 29 November 2013

Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone

scientific article

Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

scientific article published on 13 March 2015

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

scientific article

Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis

scientific article published in November 2004

Lysophospholipid receptor-mediated calcium signaling in human keratinocytes

scientific article published on 3 January 2008

Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring

scientific article

Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis

scientific article published on 04 September 2020

Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement ⬇️

scientific article published on February 13, 2012

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

scientific article published on 16 January 2013

Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52.

scientific article

Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation

scientific article published on 18 May 2010

Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?

scientific article published on 14 March 2020

Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - Composition-dependent skin penetration enhancement of a dye probe and biocompatibility

scientific article published on 27 October 2016

Reconstructed epidermis and full-thickness skin for absorption testing: influence of the vehicles used on steroid permeation.

scientific article published in September 2008

Regulation of hematogenous tumor metastasis by acid sphingomyelinase

scientific article

Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease

scientific article

Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice

scientific article published on 9 July 2017

Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers

scientific article published on 10 September 2020

Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin

scientific article published on 24 December 2016

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

scientific article

Sphingolipids and inflammatory diseases of the skin

scientific article published on January 2013

Sphingolipids as targets for inhalation treatment of cystic fibrosis.

scientific article

Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2.

scientific article published on 24 April 2015

Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₁ and S1P₃ and Smad-signalling

scientific article published on 10 November 2010

Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype

scientific article

Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃.

scientific article published on 17 August 2012

Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype

scientific article published on 24 January 2008

Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages

scientific article

Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing

scientific article (publication date: April 2003)

Sphingosine-1-phosphate as signaling molecule in the skin: Relevance in atopic dermatitis

scientific article published on 19 March 2014

Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis

scientific article published on 6 April 2013

Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation

scientific article

Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo

scientific article

Sphingosine-1-phosphate signaling and the skin

scientific article

Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis

scientific article published on 30 September 2016

Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing

scientific article published on 24 June 2016

The Enigma of Sphingolipids in Health and Disease

article

The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells

scientific article published on 13 March 2024

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death

scientific article

The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells

scientific article published on March 2006

The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

scientific article published on June 2015

The role of sphingosine-1-phosphate receptor modulators in the prevention of transplant rejection and autoimmune diseases.

scientific article

The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology

scientific article published on 10 July 2006

The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro

scientific article published on 06 June 2017

Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration

scientific article published on 5 February 2009

Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene.

scientific article

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