List of works - Mitsunobu Kano

Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.

scientific article

Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.

scientific article

Authentic Vascular and Stromal Structure in Animal Disease Model for Nanomedicine

scientific article published in 2016

Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

scientific article

Building Experimental System Modeling Fibrotic Tissue in Human Pancreatic Cancer by Three-Dimensional Layer-by-Layer Culture

scientific article published in 2014

Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells

scientific article published on 12 June 2008

Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature.

scientific article

Considering the Significance of the Young Academy

scientific article published in May 2018

Corrigendum to “SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)” [J. Control. Release, Volume 169 (2013) 220–227]

scientific article published in March 2014

Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier.

scientific article

Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas

scientific article

Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability

scientific article

Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling

scientific article published on 07 April 2009

Engineering fibrotic tissue in pancreatic cancer: a novel three-dimensional model to investigate nanoparticle delivery.

scientific article published on 30 January 2012

Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties

scientific article published in September 2010

Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor

scientific article

Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

scientific article

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene

scientific journal article

Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma

scientific article published on November 2010

High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism

scientific article published on 12 October 2011

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

scientific article

Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest.

scientific article published on 20 December 2017

IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism

scientific article published on 01 July 2007

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

scholarly article

Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.

scientific article published on January 2011

Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.

scientific article published on 12 April 2016

Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

scientific article published on 12 August 2010

Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.

scientific article published on November 2007

Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis

scientific article

In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis

scientific article published on 02 July 2018

LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.

scientific article

NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo

scientific article

Nano-pathophysiology: a novel integrated approach to disease through application of nanotechnology

scientific article published on 01 July 2014

Nanotechnology and tumor microcirculation.

scientific article published on 30 August 2013

Okayama University's Collective Response to Advance the SDGs

scientific article published in January 2018

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

scientific article published on 09 March 2012

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness

scientific article published on 17 November 2018

Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: a retrospective observational study

scientific article published on 01 July 2019

Pericyte-coverage of human tumor vasculature and nanoparticle permeability

scientific article published on 01 January 2012

Place of death trends among patients with dementia in Japan: a population-based observational study

scientific article published on 27 December 2019

Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.

scientific article published on 3 February 2012

Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation

scientific article

Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue

scientific article published on 10 September 2008

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

scientific article published on 6 October 2010

Preceding Challenges by Dutch Young Academy

scientific article published in 2012

Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors.

scientific article

SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes).

scientific article published on 29 March 2013

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions.

scientific article published on 10 May 2014

Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment.

scientific article published on 9 June 2018

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

scientific article

Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors

scientific article published on 2 December 2015

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

scientific article published on 15 January 2014

Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis

scientific article published on 25 June 2013

Theranostic probes

scientific article published in 2011

Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.

scientific article published on 17 January 2013

Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.

scientific article published on 6 December 2010

Trends in Polypharmacy in Japan: A Nationwide Retrospective Study

scientific article published on 06 October 2018

Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997-2016

scientific article published on 9 November 2018

VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling

scientific article published on August 2005

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.

scientific article published on 15 February 2016

c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.

scientific article

List of works by Mitsunobu Kano

Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.

Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.

Authentic Vascular and Stromal Structure in Animal Disease Model for Nanomedicine

Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

Building Experimental System Modeling Fibrotic Tissue in Human Pancreatic Cancer by Three-Dimensional Layer-by-Layer Culture

Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells

Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature.

Considering the Significance of the Young Academy

Corrigendum to “SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)” [J. Control. Release, Volume 169 (2013) 220–227]

Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier.

Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas

Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability

Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling

Engineering fibrotic tissue in pancreatic cancer: a novel three-dimensional model to investigate nanoparticle delivery.

Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties

Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor

Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene

Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma

High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest.

IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.

Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.

Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.

Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis

In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis

LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.

NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo

Nano-pathophysiology: a novel integrated approach to disease through application of nanotechnology

Nanotechnology and tumor microcirculation.

Okayama University's Collective Response to Advance the SDGs

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness

Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: a retrospective observational study

Pericyte-coverage of human tumor vasculature and nanoparticle permeability

Place of death trends among patients with dementia in Japan: a population-based observational study

Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.

Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation

Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

Preceding Challenges by Dutch Young Academy

Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors.

SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes).

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions.

Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment.

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis

Theranostic probes

Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.

Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.

Trends in Polypharmacy in Japan: A Nationwide Retrospective Study

Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997-2016

VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.

c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.