List of works - Hans Kaspar Binz

A novel strategy to design binding molecules harnessing the modular nature of repeat proteins.

scientific article published in March 2003

Beyond Antibodies: The DARPin® Drug Platform

scientific article published on 24 June 2020

Consensus design of repeat proteins.

scientific article published in February 2004

Crystal structure of a consensus-designed ankyrin repeat protein: Implications for stability

scientific article published on 01 November 2006

DARPins: a new generation of protein therapeutics.

scientific article

Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate.

scientific article published on 16 October 2017

Designing repeat proteins: modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family.

scientific article

Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

scientific article

Engineered proteins as specific binding reagents.

scientific article published in August 2005

Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins.

scientific article

Folding of a designed simple ankyrin repeat protein.

scientific article

Highly potent VEGF-A-antagonistic DARPins as anti-angiogenic agents for topical and intravitreal applications ⬇️

scientific article published on September 15, 2012

Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins

article

Mutational analysis of the interaction between albumin-binding domain from streptococcal protein G and human serum albumin

scientific article

Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

scientific article

Targeting extracellular domains D4 and D7 of vascular endothelial growth factor receptor 2 reveals allosteric receptor regulatory sites

scientific article

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

scientific article published in 2022

List of works by Hans Kaspar Binz

A novel strategy to design binding molecules harnessing the modular nature of repeat proteins.

Beyond Antibodies: The DARPin® Drug Platform

Consensus design of repeat proteins.

Crystal structure of a consensus-designed ankyrin repeat protein: Implications for stability

DARPins: a new generation of protein therapeutics.

Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate.

Designing repeat proteins: modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family.

Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

Engineered proteins as specific binding reagents.

Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins.

Folding of a designed simple ankyrin repeat protein.

Highly potent VEGF-A-antagonistic DARPins as anti-angiogenic agents for topical and intravitreal applications ⬇️

Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins

Mutational analysis of the interaction between albumin-binding domain from streptococcal protein G and human serum albumin

Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

Targeting extracellular domains D4 and D7 of vascular endothelial growth factor receptor 2 reveals allosteric receptor regulatory sites

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants