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List of works by Razvan L Cornea

A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML.

scientific article published on 30 September 2013

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

scientific article published on 27 March 2019

Calmodulin oxidation and methionine to glutamine substitutions reveal methionine residues critical for functional interaction with ryanodine receptor-1.

scientific article published on 13 February 2003

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.

scientific article published on November 2013

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

scientific article published on 16 November 2021

Close proximity between residue 30 of phospholamban and cysteine 318 of the cardiac Ca2+ pump revealed by intermolecular thiol cross-linking.

scientific article published on 15 May 2002

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

scientific article

Defining the molecular components of calcium transport regulation in a reconstituted membrane system

scientific article published on 01 April 2003

Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells.

scientific article published on February 2014

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

scientific article published on 21 February 2014

Effects of membrane thickness on the molecular dynamics and enzymatic activity of reconstituted Ca-ATPase.

scientific article published in March 1994

FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel

scientific journal article

FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel

scientific article

Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure.

scientific article published on 12 April 2011

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels

scientific article published on 22 October 2016

High-throughput FRET assay yields allosteric SERCA activators

scientific article

Identification of a dihydropyridine scaffold that blocks ryanodine receptors

scientific article published on 27 December 2021

In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding

scientific article

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

scientific article

Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer

scientific article

Mutation and phosphorylation change the oligomeric structure of phospholamban in lipid bilayers

scientific article published on 01 March 1997

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

scientific article

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

scientific article

Phosphorylation-induced structural change in phospholamban and its mutants, detected by intrinsic fluorescence

scientific article published on 01 May 1998

Reexamination of the role of the leucine/isoleucine zipper residues of phospholamban in inhibition of the Ca2+ pump of cardiac sarcoplasmic reticulum

scientific article published on 01 December 2000

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

scientific article published on 04 February 2020

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex

scientific article published on 19 May 2016

Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer

scientific article

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells

scientific article published in Scientific Reports

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

scientific article published on 30 July 2019

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

scientific article published on 21 February 2019

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