List of works - Lei Zheng

A Phase 2 Study of Allogeneic GM-CSF Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer

scientific article published on 26 June 2020

A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer

scientific article published on 26 December 2019

A preclinical murine model of hepatic metastases

scientific article

A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer

scientific article

Annexin A2 is a new antigenic target for pancreatic cancer immunotherapy

scientific article

Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

scientific article published on 22 May 2019

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

scientific article published on 01 June 2019

CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma

scientific article published on 11 April 2022

Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation

scientific article published on 5 August 2016

Clinical presentation of immune checkpoint inhibitor-induced inflammatory arthritis differs by immunotherapy regimen

Current progress in immunotherapy for pancreatic cancer

scientific article published on 23 December 2015

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

scientific article

Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer

scientific article published on 11 June 2019

Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment

scientific article published in September 2017

Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.

scientific article published on 27 October 2012

Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer

scientific article

Evaluation of predictive variables in locally advanced pancreatic adenocarcinoma patients receiving definitive chemoradiation.

scientific article

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

scientific article published on June 2016

Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2.

scientific article published on 2 February 2017

Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer.

scientific article published on 7 November 2016

Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.

scientific article published on 3 January 2013

Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation

scientific article

Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer

scientific article published on 01 July 2020

LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.

scientific article published on 8 September 2017

Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer

scientific article published on 21 June 2017

Low total lymphocyte count is associated with poor survival in patients with resected pancreatic adenocarcinoma receiving a GM-CSF secreting pancreatic tumor vaccine

scientific article published on 18 September 2013

Managing cardiotoxicity associated with immune checkpoint inhibitors

scientific article published on 21 March 2019

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

scientific article

NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma

scientific article published on 01 January 2020

Nonfatal unintentional injuries and related factors among male construction workers in central China

scientific article published in June 2010

Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer.

scientific article published on 19 April 2017

Overcoming the resistance of pancreatic cancer to immune checkpoint inhibitors

scientific article

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition.

scientific article published on 6 October 2014

Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

scientific article published on November 2014

Prognostic validity of the American joint committee on cancer eighth edition staging system for well-differentiated pancreatic neuroendocrine tumors

scientific article published in 2022

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis.

scientific article

Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens

scientific article published on 19 December 2018

Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma

scientific article published on June 2013

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

scientific article published on 4 August 2015

Specificity delivers: therapeutic role of tumor antigen-specific antibodies in pancreatic cancer

scientific article

Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective.

scientific article published on 23 October 2017

Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes

scientific article published on 01 January 2021

Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer

scientific article published on 15 November 2017

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

scientific article published on 15 October 2015

Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

scientific article published on 13 November 2018

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

scientific article

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

scientific article published on 12 May 2020

Tumor Mutational Burden, Toxicity and Response of Immune Checkpoint Inhibitors (ICIs) Targeting PD(L)1, CTLA-4, and Combination: A Meta-Regression Analysis

scientific article published on 25 June 2020

Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer

scientific article (publication date: 29 April 2011)

Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.

scientific article published on 3 February 2016

Vaccine therapy for pancreatic cancer

scientific article published on 22 October 2013

Vaccine-Induced Intratumoral Lymphoid Aggregates Correlate with Survival Following Treatment with a Neoadjuvant and Adjuvant Vaccine in Patients with Resectable Pancreatic Adenocarcinoma

scientific article published on 04 December 2020

Vaccines for pancreatic cancer

scientific article

List of works by Lei Zheng

A Phase 2 Study of Allogeneic GM-CSF Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer

A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer

A preclinical murine model of hepatic metastases

A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer

Annexin A2 is a new antigenic target for pancreatic cancer immunotherapy

Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma

Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation

Clinical presentation of immune checkpoint inhibitor-induced inflammatory arthritis differs by immunotherapy regimen

Current progress in immunotherapy for pancreatic cancer

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer

Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment

Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.

Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer

Evaluation of predictive variables in locally advanced pancreatic adenocarcinoma patients receiving definitive chemoradiation.

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2.

Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer.

Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.

Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation

Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer

LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.

Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer

Low total lymphocyte count is associated with poor survival in patients with resected pancreatic adenocarcinoma receiving a GM-CSF secreting pancreatic tumor vaccine

Managing cardiotoxicity associated with immune checkpoint inhibitors

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma

Nonfatal unintentional injuries and related factors among male construction workers in central China

Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer.

Overcoming the resistance of pancreatic cancer to immune checkpoint inhibitors

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition.

Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

Prognostic validity of the American joint committee on cancer eighth edition staging system for well-differentiated pancreatic neuroendocrine tumors

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis.

Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens

Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Specificity delivers: therapeutic role of tumor antigen-specific antibodies in pancreatic cancer

Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective.

Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes

Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Tumor Mutational Burden, Toxicity and Response of Immune Checkpoint Inhibitors (ICIs) Targeting PD(L)1, CTLA-4, and Combination: A Meta-Regression Analysis

Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer

Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.

Vaccine therapy for pancreatic cancer

Vaccine-Induced Intratumoral Lymphoid Aggregates Correlate with Survival Following Treatment with a Neoadjuvant and Adjuvant Vaccine in Patients with Resectable Pancreatic Adenocarcinoma

Vaccines for pancreatic cancer