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List of works by Ian Andrew Wilson

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

scientific article published on 21 December 2017

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase

scientific article published on October 2003

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

scientific article

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

scientific article

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

scientific article

A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

scientific article

A Distinct Type of Pilus from the Human Microbiome

scientific article

A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions

scientific article published on 10 August 2015

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus

scientific article

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

scientific article

A Structural Basis for the Regulatory Inactivation of DnaA

scientific article

A Unique and Conserved Neutralization Epitope in H5N1 Influenza Viruses Identified by an Antibody against the A/Goose/Guangdong/1/96 Hemagglutinin

scientific article

A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.

scientific article published on 31 May 2018

A common solution to group 2 influenza virus neutralization

scientific article

A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution

scientific article

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

scientific article

A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans

scientific article published on 8 June 2015

A highly conserved neutralizing epitope on group 2 influenza A viruses

scientific article

A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors.

scientific article

A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy

scientific article published in September 2003

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.

scientific article published on 10 July 2018

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

scientific article

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

scientific article

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

scientific article

A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120

scientific article

A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects

scientific article

A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

scientific article

A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.

scientific article

A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin

scientific article published on 2 April 2018

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

scientific article

A structural analysis of M protein in coronavirus assembly and morphology

scientific article

A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union

scientific article

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

scientific article published on December 2015

Alternative Recognition of the Conserved Stem Epitope in Influenza A Virus Hemagglutinin by a VH3-30-Encoded Heterosubtypic Antibody

scientific article

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

scientific article published on 29 September 2020

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

scientific article

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

scientific article

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10

scientific article

An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket

scientific article

An unusual dimeric structure and assembly for TLR4 regulator RP105–MD-1 ⬇️

scientific article published on August 21, 2011

An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219 ⬇️

scientific article published on December 1, 2010

Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution

scientific article

Anatomy of CD1-lipid antigen complexes

scientific article

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

scientific article

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem

scientific article published on September 2017

Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site

scientific article

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

scientific article

Antibody elbow angles are influenced by their light chain class

scientific article published on 25 January 2006

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

scientific article

Antibody recognition of a highly conserved influenza virus epitope

scientific article

Antibody vs. HIV in a clash of evolutionary titans

scientific article

Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy

scientific article published on 31 January 2007

Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding

scientific article

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

scientific article

Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits

scientific article published on 17 March 2020

Bacterial Glycosyltransferase-mediated Cell-surface Chemoenzymatic Glycan Editing: Methods and Applications

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

scientific article

Bifunctional catalysis of proton transfer at an antibody active site

scientific article

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

scientific article

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors

scientific article

Biochemical characterization and structural analysis of a highly proficient cocaine esterase

scientific article

Biological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide Transformylase

scientific article

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

scientific article

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

scientific article published on 24 April 2014

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

scientific article (publication date: February 2005)

Broadly neutralizing antibodies against influenza virus and prospects for universal therapies

scientific article

CD1 assembly and the formation of CD1-antigen complexes

scientific article

CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans

scientific article

CD4-induced activation in a soluble HIV-1 Env trimer

scientific article

Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design

scientific article

Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin

scientific article

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

scientific article published on 21 October 2013

Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus

scholarly article by Wenda Guan et al published 8 September 2018 in Journal of Infectious Diseases

Closely related antibody receptors exploit fundamentally different strategies for steroid recognition

scientific article

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

article

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.

scientific article published in June 2018

Cofactor-containing antibodies: crystal structure of the original yellow antibody

scholarly article

Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus

scientific article

Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10.

scientific article published on 23 March 2004

Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus

scientific article published on 16 April 2008

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution

scientific article published in November 2006

Comparison of NMR and crystal structures for the proteins TM1112 and TM1367

scientific article

Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites

scientific article

Complement is activated by IgG hexamers assembled at the cell surface

scientific article

Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer

scientific article published on 26 September 2015

Complete reaction cycle of a cocaine catalytic antibody at atomic resolution.

scientific article

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

scientific article

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

scientific article

Conformational Isomerism Can Limit Antibody Catalysis

scientific article

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

scientific article published on 01 June 2019

Conformational changes associated with the binding of zinc acetate at the putative active site of Xc TcmJ, a cupin from Xanthomonas campestris pv. campestris

scientific article

Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers.

scientific article

Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

scientific article published on 29 June 2020

Correction for Doores et al., Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope

scientific article published on June 2015

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

scientific article published on 14 September 2016

Correction: Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes

scientific article

Covalent display of oligosaccharide arrays in microtiter plates

scientific article published in July 2004

Cross-neutralization of influenza A viruses mediated by a single antibody loop

scientific article

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome

scientific article

Crystal Structure of Histidine Phosphotransfer Protein ShpA, an Essential Regulator of Stalk Biogenesis in Caulobacter crescentus

scientific article

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair

scientific article

Crystal Structure of the Human N-Myc Downstream-regulated Gene 2 Protein Provides Insight into Its Role as a Tumor Suppressor

scientific article

Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids

scientific article

Crystal Structures of a Quorum-quenching Antibody

scientific article

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution

scientific article

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 A resolution reveals a new fold with a novel active site

scientific article

Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution

scientific article

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A

scientific article

Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 Å resolution

article

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif

scientific article (publication date: 28 February 2003)

Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 angstroms resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

scientific article

Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases

scientific article

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution

scientific article published in August 2004

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold

scientific article

Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function

scientific article published in July 2007

Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold

scientific article published in June 2006

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution

scientific article

Crystal structure of a bacterial cocaine esterase

scientific article

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 Å resolution reveals a new fold

article

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold

scientific article

Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262.

scientific article published on 22 January 2015

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 Å resolution reveals a new fold

article

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution

scientific article published in July 2004

Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site

scientific article

Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity

scientific article

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution

scientific article

Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors

scientific article

Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design

scientific article

Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution

scientific article

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution

scientific article published in August 2004

Crystal structure of a novel archaeal AAA+ ATPase SSO1545 fromSulfolobus solfataricus

scientific article

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution

scientific article

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution

scientific article published in May 2004

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution

scientific article

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution

scientific article published in March 2004

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution

scientific article published in March 2004

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold

scientific article

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution

scientific journal article

Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family

scientific article

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution

scientific article

Crystal structure of a shark single-domain antibody V region in complex with lysozyme

scientific article

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 Å resolution

article

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution

scientific article

Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution

scientific article

Crystal structure of a two-subunit TrkA octameric gating ring assembly

scientific article published in 2015

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution.

scientific article published in May 2004

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution

scientific article

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution

scientific article

Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution

scientific article

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution

scientific article

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution

scientific article published in March 2004

Crystal structure of an ORFan protein (TM1622) fromThermotoga maritimaat 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p

article

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution

scientific article published in June 2004

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor

scientific article published in March 2005

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution

scientific article

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution

scientific article

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution

scientific article published in May 2004

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 Å resolution reveals a new fold

article

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution

scientific article

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold

scientific article published in August 2004

Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening

scientific article published on 7 September 2004

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution

scientific article

Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution

scientific article

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

scientific article

Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A

scientific article

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation

scientific article published on July 2005

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution

scientific article published in October 2006

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution

scientific article

Crystal structure of soluble MD-1 and its interaction with lipid IVa

scientific article

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution

article

Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution

scientific article

Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 Å resolution

scientific article

Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose

scientific article

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

scholarly article

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold

scientific article published in November 2005

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution

scientific article

Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution

scientific article

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold

scientific article

Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold

scientific article

Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine

scientific article published in May 2005

Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR

scientific article

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates

scientific article

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity

scientific article published on June 2006

Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake

scientific article

Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif

scientific article

Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B

scientific article

Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site ⬇️

scientific article published on September 24, 2012

Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex

scientific article

Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer

scientific article published on 29 April 2015

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d

scholarly article

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

scientific article published in October 2003

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

scientific article

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase

scientific article published on October 2003

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

scientific article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

scientific article

Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase

scientific article

Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.

scientific article

Divergent evolution of protein conformational dynamics in dihydrofolate reductase

scientific article

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin

scientific article published on June 2017

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin

scientific article published on August 2017

Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome

scientific article

Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding

scientific article published on 06 July 2016

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

scientific article

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

article

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

scientific article published on October 2017

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

scientific article

Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide

scientific article published on November 2006

Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens

scholarly article

Exploration of uncharted regions of the protein universe

scientific article published in September 2009

Expression and characterization of a humanized cocaine-binding antibody

scientific article published in June 2003

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

scientific article

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex

scientific article published on April 2002

Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic ⬇️

scientific article published on June 20, 2012

Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima

scientific article

Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria

scientific article

Genome pool strategy for structural coverage of protein families

scientific article

Genomics, evolution, and crystal structure of a new family of bacterial spore kinases

scientific article

Geranylgeranyl switching regulates GDI-Rab GTPase recycling

scientific article (publication date: March 2003)

Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.

scientific article

Glycan microarray technologies: tools to survey host specificity of influenza viruses.

scientific article published on 2 October 2006

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

scientific article

Glycosylation and the function of the T cell co-receptor CD8.

scientific article published in January 2005

H7N9 influenza virus neutralizing antibodies that possess few somatic mutations

scientific article

HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

scientific article published in November 2017

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

scientific article published on 07 September 2016

HIV vaccine design and the neutralizing antibody problem

scientific article published in March 2004

HIV's Achilles' Heel

scientific article published on November 2016

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 and influenza antibodies: seeing antigens in new ways

scientific article

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

scientific article

HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

scientific article published on October 2016

Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses

scientific article

Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities

scientific article

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

scientific article

Highly Conserved Protective Epitopes on Influenza B Viruses

scientific article

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

scientific article published on 17 August 2016

Hyperglycosylated Mutants of Human Immunodeficiency Virus (HIV) Type 1 Monomeric gp120 as Novel Antigens for HIV Vaccine Design ⬇️

scientific article published on May 1, 2003

Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA

scientific article

Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation

scientific article published on 31 July 2013

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Immunological memory to hyperphosphorylated tau in asymptomatic individuals

scientific article

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

scientific article

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

scientific article published on 15 May 2017

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

scientific article published on 26 August 2015

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

scientific article

Influenza Virus Neuraminidases with Reduced Enzymatic Activity That Avidly Bind Sialic Acid Receptors ⬇️

scientific article published on September 26, 2012

Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120

article

Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120.

scientific article

Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids

scientific article

Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains

scientific article published on 15 September 2015

Insights into the trimeric HIV-1 envelope glycoprotein structure

scientific article

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages

scientific article

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

scientific article

Kinetic stabilization of an oligomeric protein by a single ligand binding event

scientific article published in April 2005

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis

scientific article

Ligands in PSI structures ⬇️

scientific article published on July 6, 2010

Malachite Green Mediates Homodimerization of Antibody VL Domains to Form a Fluorescent Ternary Complex with Singular Symmetric Interfaces

scientific article

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

scientific article published on 31 August 2020

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

scientific article

Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso

scientific article

Molecular characterization of novel pyridoxal-5′-phosphate-dependent enzymes from the human microbiome

scientific article

Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.

scientific article

Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure

scientific article

NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia

scientific article

NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline

scientific article

NMR structure of the protein NP_247299.1: comparison with the crystal structure

scientific article

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria

scientific article published on 20 August 2006

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.

scientific article

New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation

scientific article

New world bats harbor diverse influenza A viruses

scientific article published in 2013

Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies

scientific article

Observation of an arsenic adduct in an acetyl esterase crystal structure

scientific article

Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding

scientific article

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

scientific article published on 12 July 2017

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

scientific article

Organization of the influenza virus replication machinery

scientific article

Outcome of a workshop on applications of protein models in biomedical research

scientific article (publication date: 13 February 2009)

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

scientific article

Preferential Recognition of Avian-Like Receptors in Human Influenza A H7N9 Viruses

scientific article

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins

scientific article

Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism

scientific article published in January 2002

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

scientific article published on May 2014

Protein production and purification

scientific article

Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase

scientific article published on 12 September 2006

Rapid development of glycan-specific, broad, and potent anti–HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque ⬇️

scientific article published on November 28, 2011

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

scientific article published on 20 July 2017

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.

scholarly article

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

scientific article

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

scientific article (publication date: 27 May 2003)

Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269.

scientific article published on August 2007

Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody

scientific article published on February 2004

Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity.

scientific article

Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

scientific article

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

scientific article

Recombinant expression of TLR5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique ⬇️

scientific article published on September 16, 2012

Reconstruction of the 1918 influenza virus: unexpected rewards from the past

scientific article

Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene

article

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop ⬇️

scientific article published on October 10, 2003

Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

scientific article

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

scientific article

Reshaping Antibody Diversity

scientific article

Role of lipid trimming and CD1 groove size in cellular antigen presentation

scientific article published on 22 June 2006

Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation

scientific article published on 19 June 2017

Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems

scientific article published on 10 March 2003

Selecting agonists from single cells infected with combinatorial antibody libraries

scientific article

Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries ⬇️

scientific article published on September 10, 2012

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

scientific article

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors

scientific article published on 26 May 2017

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.

scientific article

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.

scientific article

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids

scientific article published on 03 March 2014

Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence

scientific article published on 5 April 2006

Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

scientific article

Specific recognition of a DNA immunogen by its elicited antibody

scientific article

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

scientific article published on 8 December 2017

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

scientific article published on 25 April 2014

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

scientific article

Stilbene Vinyl Sulfonamides as Fluorogenic Sensors of and Traceless Covalent Kinetic Stabilizers of Transthyretin That Prevent Amyloidogenesis

scientific article

Structural Analysis of Papain-Like NlpC/P60 Superfamily Enzymes with a Circularly Permuted Topology Reveals Potential Lipid Binding Sites

scientific article

Structural Basis for Antibody Catalysis of a Cationic Cyclization Reaction ⬇️

scientific article (publication date: 23 May 2003)

Structural Basis for Ligand Recognition and Discrimination of a Quorum-quenching Antibody ⬇️

scientific article published on March 23, 2011

Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

scientific article published on 11 October 2018

Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants

scientific article published on 11 November 2015

Structural Basis of Murein Peptide Specificity of a γ-D-Glutamyl-L-Diamino Acid Endopeptidase

scientific article

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

scientific article

Structural Characterization of an Early Fusion Intermediate of Influenza Virus Hemagglutinin ⬇️

scientific article published on March 2, 2011

Structural Characterization of the 1918 Influenza Virus H1N1 Neuraminidase

scientific article

Structural Characterization of the Hemagglutinin Receptor Specificity from the 2009 H1N1 Influenza Pandemic ⬇️

scientific article published on November 9, 2011

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

scientific article

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

scientific article published on 16 June 2015

Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates

scientific article

Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications

scientific article

Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering

scientific article

Structural and Sequence Analysis of Imelysin-Like Proteins Implicated in Bacterial Iron Uptake

scientific article

Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes

scientific article

Structural and thermodynamic correlates of T cell signaling

scientific article

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity

scientific article

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein

scientific article published on 14 November 2017

Structural basis of TLR5-flagellin recognition and signaling

scientific article

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

scientific article published on 10 November 2006

Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1 ⬇️

scientific article published on May 23, 2012

Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol

scientific article

Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d

scientific article published on October 2006

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

scientific article

Structural evolution of glycan recognition by a family of potent HIV antibodies

scientific article

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline

scientific article

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

scientific article

Structural insights into the avian AICAR transformylase mechanism

scientific article

Structural insights into the design of novel anti-influenza therapies

scientific article

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor

scientific article

Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin

scientific article

Structural origins of efficient proton abstraction from carbon by a catalytic antibody

scientific article

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D

scientific article

Structure and Function of a Novel LD-Carboxypeptidase A Involved in Peptidoglycan Recycling

scientific article

Structure and Function of the DUF2233 Domain in Bacteria and in the Human Mannose 6-Phosphate Uncovering Enzyme

scientific article

Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein

scientific article

Structure and Functional Characterization of the RNA-Binding Element of the NLRX1 Innate Immune Modulator ⬇️

scientific article published on March 23, 2012

Structure and Immune Recognition of the HIV Glycan Shield

scientific article published on 29 March 2018

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor

scientific article

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

scientific article

Structure determination of a cocaine hydrolytic antibody from a pseudomerohedrally twinned crystal

scientific article published on 23 November 2002

Structure determination of an anti-HIV-1 Fab 447-52D–peptide complex from an epitaxially twinned data set

scientific article

Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects

scientific article

Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

scientific article

Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules

scientific article

Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism

scientific article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of Hepatitis C Virus Envelope Glycoprotein E1 Antigenic Site 314-324 in Complex with Antibody IGH526.

scientific article published on 30 June 2015

Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33

scientific article

Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism

scientific article

Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains

scientific article

Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

scientific article

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

scientific article

Structure of a Virulence Regulatory Factor CvfB Reveals a Novel Winged Helix RNA Binding Module

scientific article

Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies

scientific article

Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron

scientific article

Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15

scientific article

Structure of a tryptophanyl-tRNA synthetase containing an iron–sulfur cluster

scientific article

Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes

scientific article

Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution

scientific article

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site

scientific article

Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA

scientific article

Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation

scientific article

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

scientific article

Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization

scientific article

Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus

scientific article

Structure of the γ- D -glutamyl- L -diamino acid endopeptidase YkfC from Bacillus cereus in complex with L -Ala-γ- D -Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases

scientific article

Structure, Receptor Binding, and Antigenicity of Influenza Virus Hemagglutinins from the 1957 H2N2 Pandemic

scientific article

Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease

scholarly article by Cy V Credille et al published 16 October 2018 in Journal of Medicinal Chemistry

Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

scientific article

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

scientific article

Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase

scientific article

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

scientific article

Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase

scientific article published on January 2003

Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin

scientific article published on 28 June 2017

Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody

scientific article

Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family

scientific article

Structures of a Bifunctional Cell Wall Hydrolase CwlT Containing a Novel Bacterial Lysozyme and an NlpC/P60 dl-Endopeptidase

scientific article

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

scientific article

Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism

scientific article

Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction

scientific article

Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger

scientific article

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

scientific article

Supine orientation of a murine MHC class I molecule on the membrane bilayer

scientific article

Synthesis and Toll-like Receptor 4 (TLR4) Activity of Phosphatidylinositol Dimannoside Analogues ⬇️

scientific article published on 05 October 2011

Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway

scientific article

Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.

scientific article published in May 2005

T Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational Rearrangements ⬇️

scientific article published on January 19, 2012

T cells control the generation of nanomolar-affinity anti-glycan antibodies

scientific article published on 13 March 2017

TM0486 from the Hyperthermophilic Anaerobe Thermotoga maritima is a Thiamin-binding Protein Involved in Response of the Cell to Oxidative Conditions

scientific article

TOPSAN: a collaborative annotation environment for structural genomics

scientific article

TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures

scientific article

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

scientific article

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

article

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

scientific article

The HIV-1 envelope glycoprotein structure: nailing down a moving target

scientific article published on January 2017

The JCSG high-throughput structural biology pipeline

scientific article (publication date: October 2010)

The Molecular Interaction of CAR and JAML Recruits the Central Cell Signal Transducer PI3K ⬇️

scientific article published on September 3, 2010

The Structure of Mlc Titration Factor A (MtfA/YeeI) Reveals a Prototypical Zinc Metallopeptidase Related to Anthrax Lethal Factor

scientific article

The Unusual Genetics and Biochemistry of Bovine Immunoglobulins

scientific article

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

scientific article

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.

scientific article

The challenge of protein structure determination--lessons from structural genomics.

scientific article

The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

scientific article

The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1

scientific article

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity

scientific article

The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis

scientific article

The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion

scientific article

The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function

scientific article

The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes

scientific article

The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator

scientific article

The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae , reveals an OB-fold

scientific article

The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role

scientific article

The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism

scientific article

The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation

scientific article

Three-dimensional structural view of the central metabolic network of Thermotoga maritima

scientific article

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

scientific article

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

scientific article

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR.

scientific article published on 9 November 2005

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

scientific article

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope

scientific article

UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex

scientific article published on 24 March 2016

Unique Structural Features of Influenza Virus H15 Hemagglutinin

scientific article published on 12 April 2017

Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta

scientific article (publication date: February 2003)

VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies

scientific article published on 26 March 2018

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes

scientific article

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

scholarly article by Matthias G Pauthner et al published 15 January 2019 in Immunity

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

scientific article

Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores ⬇️

scientific article published on March 7, 2012

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors

scientific article

XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators

scientific article

cDNA Sequence and Fab Crystal Structure of HL4E10, a Hamster IgG Lambda Light Chain Antibody Stimulatory for γδ T Cells ⬇️

scientific article published on May 24, 2011

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate

scientific article

pH-dependent interdomain tethers of CD1b regulate its antigen capture

scientific article published on June 2008

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