List of works - Adrie J C Steyn

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

scientific article published on 9 March 2018

Mycobacterium tuberculosis causes a leaky blood‐brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring

scientific article published on 11 May 2021

A Feedback Regulatory Loop Containing McdR and WhiB2 Controls Cell Division and DNA Repair in Mycobacteria

scientific article published on 26 April 2022

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing

scientific article published on 24 November 2021

A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions

scientific article published on 26 October 2022

A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis

scientific journal article

A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria

scientific article

Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

scholarly article

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response

scientific article published on 02 December 2021

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

scientific article published on 09 October 2018

Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections.

scientific article published on 30 September 2016

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles

scientific article published in 2024

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

scientific article published on 30 November 2020

Characterization of a novel alpha-amylase from Lipomyces kononenkoae and expression of its gene (LKA1) in Saccharomyces cerevisiae

scientific article published on 01 November 1995

Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.

scientific article

Cloning and characterization of a second alpha-amylase gene (LKA2) from Lipomyces kononenkoae IGC4052B and its expression in Saccharomyces cerevisiae.

scientific article published on January 2003

Comprehensive examination of the mouse lung metabolome following Mycobacterium tuberculosis infection using a multiplatform mass spectrometry approach

scientific article published on 14 April 2020

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

scientific article published on 01 December 2019

Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA

scientific journal article

Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.

scientific article published on 14 July 2017

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

scientific article published on 01 January 2020

Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association.

scientific article

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

scientific article published on 07 December 2020

Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis.

scientific article

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

scientific article published on 6 January 2016

Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness

scientific article

Expression and secretion of Bacillus amyloliquefaciens alpha-amylase by using the yeast pheromone alpha-factor promoter and leader sequence in Saccharomyces cerevisiae.

scientific article

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.

scientific article published on 3 May 2018

Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants

scientific article published on 30 June 2020

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

scientific article published on 05 June 2019

HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

scientific article published on 5 October 2021

Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria

scientific article

Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon

scientific article published on 9 April 2008

Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays

scientific article published on 17 September 2021

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase

Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.

scientific article

Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

scientific article published in 2024

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

scientific article published on 05 March 2020

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

scientific article published on 28 January 2020

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

scientific article published on 27 August 2019

Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family

scientific journal article

Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis

scientific article published on 04 April 2012

Metabolic plasticity of central carbon metabolism protects mycobacteria.

scientific article

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

article

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

scientific article published on 01 September 2019

Micro–Computed Tomography Analysis of the Human Tuberculous Lung Reveals Remarkable Heterogeneity in Three-dimensional Granuloma Morphology

scientific article published in 2021

Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish.

scientific article published on 17 August 2016

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the DosR dormancy regulon

scientific article published in June 2022

Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor

scientific journal article

Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility

scientific article published on 13 August 2021

Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.

scientific article

Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response

scientific journal article

Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival

scientific journal article

Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence.

scientific article published on April 2012

Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.

scientific article

Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection

scientific article

Mycobacterium tuberculosis-Induced Maternal Immune Activation Promotes Autism-Like Phenotype in Infected Mice Offspring

scientific article published on 23 April 2021

NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

scientific article published in 2023

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

scientific article published on 23 January 2020

Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

scientific article published on 01 August 2019

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

scholarly article published on 12 January 2024

RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance

scientific article

Recent developments in mycobacterial research.

scientific article published on October 1999

Redox homeostasis in mycobacteria: the key to tuberculosis control?

scientific article

Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence.

scientific article published on January 2010

Regional sequence homologies in starch-degrading enzymes.

scientific article published in November 1993

Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity

scientific article

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

scientific article published on 18 September 2020

Remembering the Host in Tuberculosis Drug Development

scientific article published on 01 April 2019

Role of Ergothioneine in Microbial Physiology and Pathogenesis.

scientific article

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis

scientific article

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.

scientific article

The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis

scientific article published in 2022

The Analysis of Mycobacterium tuberculosis-Induced Bioenergetic Changes in Infected Macrophages Using an Extracellular Flux Analyzer

scientific article published on 01 January 2020

The Physiology and Genetics of Oxidative Stress in Mycobacteria.

scientific article published on June 2014

The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

scientific article published on 10 November 2020

The emerging role of gasotransmitters in the pathogenesis of tuberculosis

scientific article

The immunoregulatory landscape of human tuberculosis granulomas

scientific article published on 20 January 2022

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung

scientific article published on 13 April 2021

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

scientific article published on 10 August 2016

Use of Telepathology to Facilitate COVID-19 Research and Education through an Online COVID-19 Autopsy Biorepository

scientific article published in January 2021

induces decelerated bioenergetic metabolism in human macrophages

scientific article published on 16 November 2018

List of works by Adrie J C Steyn

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

<i>Mycobacterium tuberculosis</i> causes a leaky blood‐brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring

A Feedback Regulatory Loop Containing McdR and WhiB2 Controls Cell Division and DNA Repair in Mycobacteria

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing

A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions

A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis

A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria

Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

Aggregated <i>Mycobacterium tuberculosis</i> Enhances the Inflammatory Response

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections.

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Characterization of a novel alpha-amylase from Lipomyces kononenkoae and expression of its gene (LKA1) in Saccharomyces cerevisiae

Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.

Cloning and characterization of a second alpha-amylase gene (LKA2) from Lipomyces kononenkoae IGC4052B and its expression in Saccharomyces cerevisiae.

Comprehensive examination of the mouse lung metabolome following Mycobacterium tuberculosis infection using a multiplatform mass spectrometry approach

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA

Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association.

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis.

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness

Expression and secretion of Bacillus amyloliquefaciens alpha-amylase by using the yeast pheromone alpha-factor promoter and leader sequence in Saccharomyces cerevisiae.

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.

Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria

Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon

Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase

Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.

Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family

Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis

Metabolic plasticity of central carbon metabolism protects mycobacteria.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

Micro–Computed Tomography Analysis of the Human Tuberculous Lung Reveals Remarkable Heterogeneity in Three-dimensional Granuloma Morphology

Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish.

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the DosR dormancy regulon

Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor

Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility

Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.

Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response

Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival

Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence.

Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.

Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection

Mycobacterium tuberculosis-Induced Maternal Immune Activation Promotes Autism-Like Phenotype in Infected Mice Offspring

NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance

Recent developments in mycobacterial research.

Redox homeostasis in mycobacteria: the key to tuberculosis control?

Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence.

Regional sequence homologies in starch-degrading enzymes.

Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

Remembering the Host in Tuberculosis Drug Development

Role of Ergothioneine in Microbial Physiology and Pathogenesis.

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.

The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis

The Analysis of Mycobacterium tuberculosis-Induced Bioenergetic Changes in Infected Macrophages Using an Extracellular Flux Analyzer

The Physiology and Genetics of Oxidative Stress in Mycobacteria.

The Role of Host-Generated H<sub>2</sub>S in Microbial Pathogenesis: New Perspectives on Tuberculosis

The emerging role of gasotransmitters in the pathogenesis of tuberculosis

The immunoregulatory landscape of human tuberculosis granulomas

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung