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List of works by Gwen Lomberk

A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding

scientific article published on 05 January 2017

A Novel Role of the Sp/KLF Transcription Factor KLF11 in Arresting Progression of Endometriosis ⬇️

scientific article published on March 28, 2013

Alcohol and pancreas

scientific article published on 14 June 2007

Angiogenesis

scientific article published on 12 May 2010

Animal models

scientific article published on 13 July 2006

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability

scientific article published on 26 May 2019

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis

scientific article published on 16 May 2019

Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis

scientific article published on 20 July 2010

Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe

scientific article

Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse

scientific article published on 10 December 2019

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

scientific article

Diabetes

scientific article published on 20 March 2009

Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake.

scientific article published on 15 January 2014

Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain

scientific article published on 06 February 2020

Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation

scientific article published on 14 September 2018

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

scientific article

Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid

scientific article

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

scientific article

Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis

scientific article

Educational websites--Bioinformatics Tools II

scientific article published on 12 December 2008

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

scientific article published on 28 August 2019

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

scientific article published on 15 September 2018

Epigenetic Silencing of Tumor Suppressor Genes in Pancreatic Cancer ⬇️

scientific article published on June 1, 2011

Epigenetics

scientific article published on 25 September 2007

Epigenetics of gastrointestinal diseases: notes from a workshop

scientific article published on 30 July 2018

Epigenetics: a promising paradigm for better understanding and managing pain

scientific article published on 19 April 2013

Evidence for the existence of an HP1-mediated subcode within the histone code

scientific article published on 12 March 2006

Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders

scientific article

Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ.

scientific article

Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins

scientific article

Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1

scientific journal article

Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

scientific article

Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression

scientific article published on 05 July 2013

Funding opportunities for rare pancreatic diseases

scientific article published on 20 May 2009

Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts

scientific article published on 08 March 2017

Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis

scientific article published on 11 September 2013

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

scientific article

Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer

scientific article

IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation

scientific article

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

scientific article

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

scientific article published in Scientific Reports

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts ⬇️

scientific article published on 06 June 2012

Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells

scientific article published on 28 February 2012

Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young

scientific article published on 15 April 2013

Laboratory skills

scientific article published on 25 January 2007

Lipid biology

scientific article published on 16 December 2009

MAGE I Transcription Factors Regulate KAP1 and KRAB Domain Zinc Finger Transcription Factor Mediated Gene Repression ⬇️

scientific article published on August 18, 2011

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

scientific article published in Scientific Reports

Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression

scientific article

Microscopy

scientific article

NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells

scientific article published on 9 October 2012

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

scientific article

Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs

scientific article

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

scientific article

Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.

scientific article published on 16 August 2012

Pain management

scientific article published on 26 September 2008

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

scientific article published in November 2017

Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes ⬇️

scientific article published on September 16, 2010

Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1.

scientific article published on 28 July 2014

Patient advocacy

scientific article published on 20 August 2008

Pharmacogenomics

scientific article published on 31 January 2008

Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes

scientific article

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.

scientific article

Polycomb Antagonizes p300/CREB-binding Protein-associated Factor to Silence FOXP3 in a Kruppel-like Factor-dependent Manner ⬇️

scientific article published on August 15, 2012

Primers on molecular pathways--caspase pathway.

scientific article published on 12 December 2008

Primers on molecular pathways--notch

scientific article published on 01 April 2008

Primers on molecular pathways--pain and opioid receptors, I.

scientific article

Primers on molecular pathways--the insulin pathway

scientific article

REG3β Plays a Key Role in IL17RA Protumoral Effect—Response

scientific article published on 18 March 2016

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss

scientific article

Restoration of epigenetically silenced SULF1 expression by 5-aza-2-deoxycytidine sensitizes hepatocellular carcinoma cells to chemotherapy-induced apoptosis

scientific article published in January 2015

Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis

scientific article

Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases

scientific article published on 8 February 2012

Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling

scientific article

Sin3: master scaffold and transcriptional corepressor

scientific article published on 06 June 2009

Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks

scientific article

Societies

scientific article published on 22 May 2008

Stem cells

scientific article published on 11 July 2007

Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms

scientific article published on 21 December 2017

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

scientific article published on 17 November 2019

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage

scientific article published on 29 May 2015

The Heterochromatin Protein 1 family

scientific article

The extracellular matrix and cell migration

scientific article published on 19 March 2010

The family feud: turning off Sp1 by Sp1-like KLF proteins

scientific article

The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research

scientific article published on September 2008

Variant anatomy of the biliary system as a cause of pancreatic and peri-ampullary cancers

scientific article published on 23 April 2020

When developmental signaling pathways go wrong and their impact on pancreatic cancer development

scientific article

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