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List of works by Rosemary Gale

A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications

scientific article published on 01 January 1999

A randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AML.

scientific article published on 21 November 2016

A truncated isoform of the human beta chain common to the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 with increased mRNA expression in some patients with acute leukemia ⬇️

scientific article published on 01 January 1998

ASXL1 mutations are infrequent in young patients with primary acute myeloid leukemia and their detection has a limited role in therapeutic risk stratification

scientific article published on 9 October 2013

Acquired skewing of X‐chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age ⬇️

scientific article published on September 1, 1997

Activating point mutations in the βC chain of the GM‐CSF, IL‐3 and IL‐5 receptors are not a major contributory factor in the pathogenesis of acute myeloid leukaemia ⬇️

scientific article published on 01 October 1998

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

scientific article published on 7 March 2017

Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication

scientific article

Acute myeloid leukaemia.

scientific article published on 10 March 2016

Amplification of mitochondrial DNA in acute myeloid leukaemia

scientific article published on 01 November 1996

An activating mutation in the transmembrane domain of the granulocyte colony-stimulating factor receptor in patients with acute myeloid leukemia

scientific article

Analysis of granulocyte colony stimulating factor receptor isoforms, polymorphisms and mutations in normal haemopoietic cells and acute myeloid leukaemia blasts

scientific article published on 01 June 1996

Analysis of mutations in the GM-CSF receptor alpha coding sequence in patients with acute myeloid leukaemia and haematologically normal individuals by RT-PCR-SSCP

scientific article published on 01 September 1994

Analysis of the clinical impact of NPM1 mutant allele burden in a large cohort of younger adult patients with acute myeloid leukaemia

scientific article published on 08 October 2019

Analysis of the coding sequence for the GM-CSF receptor alpha and beta chains in patients with juvenile chronic myeloid leukemia (JCML).

scientific article

Assessment of Minimal Residual Disease in Standard-Risk AML.

scientific article

Assessment of X-chromosome inactivation patterns using the hypervariable probe M27 beta in normal hemopoietic cells and acute myeloid leukemic blasts

scientific article published on 01 July 1992

Basic sciences of the myeloproliferative diseases: pathogenic mechanisms of ET and PV.

scientific article

Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment.

scientific article published on 8 April 2016

Clonality studies in acute myeloid leukemia ⬇️

scientific article published on February 1, 1998

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

scientific article published in July 2008

Cyclin C is a haploinsufficient tumour suppressor

scientific article

Demonstration of developing myelodysplasia/acute myeloid leukaemia in haematologically normal patients after high-dose chemotherapy and autologous bone marrow transplantation using X-chromosome inactivation patterns

scientific article published on 01 April 1996

Detection of FLT3/TKD and IDH1 Mutations in Pakistani Acute Myeloid Leukemia Patients by Denaturing HPLC.

scientific article published on 13 October 2016

Detection of leukemia-associated mutations in peripheral blood DNA of hematologically normal elderly individuals

scientific article published on 28 January 2015

Disease evolution and outcomes in familial AML with germline CEBPA mutations

scientific article published on 10 July 2015

Does BCR/ABL1 positive acute myeloid leukaemia exist?

scientific article published on 25 March 2013

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

scientific article published on 24 March 2015

Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns

scientific article published on 01 May 2000

Endothelial cells express normal cellular prion protein ⬇️

scientific article published on 01 October 2003

Expression of two alternatively spliced forms of the 5' untranslated region of the GM-CSF receptor alpha chain mRNA

scientific article published on 01 May 1996

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

scientific article published on 24 April 2007

Failure of embryonic mouse cells to engraft in immunocompetent allogeneic recipients

scientific article published on 01 April 1990

Flt3 mutations and leukaemia

scientific article

Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials. The MRC Adult Leukaemia Working Party

scientific article published on 01 March 1997

Frequency of clonal remission in acute myeloid leukaemia

scientific article published on 01 January 1993

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction

scientific article

GATA2 mutations in sporadic and familial acute myeloid leukaemia patients with CEBPA mutations

scientific article published on 5 April 2013

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

scientific article

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

scientific article published on 04 July 2016

Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

scientific article published on 04 January 2019

Glutathione S-transferase theta 1 (GSTT1) gene defect in myelodysplasia and acute myeloid leukaemia

scientific article published on 01 May 1997

Haemoglobin Radcliffe (alpha2beta299(Gi)Ala): a high oxygen-affinity variant causing familial polycythaemia

scientific article published on 01 February 1977

Hb A-like sickle haemoglobin: Hb S-providence

scientific article published on 01 October 1988

High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia

scientific article published on 01 March 2006

Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds

scientific article published on 22 November 2008

Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome.

scientific article published on 20 April 2018

Impact of FLT3(ITD) mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia.

scientific article

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.

scientific article published on 3 July 2012

Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial

scientific article

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

scientific article published on 27 March 2013

In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm.

scientific article published on 18 June 2009

In trans early mosaic mutational escape and novel phenotypic features of germline SAMD9 mutation

scientific article published on 03 January 2020

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

scientific article published on September 2008

Interpretation of X-chromosome inactivation patterns

scientific article published on 01 October 1994

Investigation of methylation at Hha I sites using the hypervariable probe M27 beta allows improved clonal analysis in myeloid leukaemia and demonstrates differences in methylation between leukaemic and remission samples

scientific article published on 01 January 1994

KIR gene haplotype: an independent predictor of clinical outcome in MDS patients

scientific article published on 19 October 2016

Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia

scientific article published on 01 October 2001

Lineage involvement in chronic myeloproliferative disorders

scientific article published on 01 August 1994

Long-term follow-up of granulocyte colony-stimulating factor receptor mutations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy.

scientific article

Long-term serial analysis of X-chromosome inactivation patterns and JAK2 V617F mutant levels in patients with essential thrombocythemia show that minor mutant-positive clones can remain stable for many years

scientific article published on 05 October 2006

Molecular MRD status and outcome after transplantation in NPM1-mutated AML

scientific article published on 01 February 2020

Most acute myeloid leukaemia patients with intermediate mutant FLT3/ITD levels do not have detectable bi-allelic disease, indicating that heterozygous disease alone is associated with an adverse outcome

scientific article published on 3 June 2008

Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party

scientific article

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease ⬇️

scientific article published on 01 November 2001

Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

scientific article published in May 2002

Mutations of the granulocyte‐colony stimulating factor receptor in patients with severe congenital neutropenia are not required for transformation to acute myeloid leukaemia and may be a bystander phenomenon ⬇️

scientific article published on 01 April 1998

Neutrophil elastase mutations in congenital neutropenia

scientific article (publication date: June 2003)

Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.

scientific article published on 17 May 2016

No evidence that CD33 splicing SNP impacts the response to GO in younger adults with AML treated on UK MRC/NCRI trials

scientific article

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.

scientific article

No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia

scientific article

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

scientific article published on 01 December 2007

Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia

article published in 2008

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.

scientific article

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

scientific article published in April 2005

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response ⬇️

scientific article published on October 5, 2012

PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways

scientific article

Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia

scientific article published on 01 July 2002

Pathogenic markers in essential thrombocythemia

scientific article

Phenotypic heterogeneity and evidence of a founder effect associated with G6PC3 mutations in patients with severe congenital neutropenia

scientific article

Plasma cell neoplasm associated chronic neutrophilic leukemia with membrane proximal and truncating CSF3R mutations

scientific article published on 01 November 2013

Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value

scientific article published on 01 October 1999

Prognostic impact of the absence of biallelic deletion at the TRG locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial

scientific article published on 08 March 2018

Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol

scientific article published on 27 July 2009

Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia

scientific article (publication date: June 2003)

Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations

scientific article published on 3 May 2010

Quantification of X-chromosome inactivation patterns in haematological samples using the DNA PCR-based HUMARA assay

scientific article published on 01 February 1996

Quantification of X-chromosome inactivation patterns using RT-PCR of the polymorphic iduronate-2-sulphatase gene and correlation of the results obtained with DNA-based techniques

scientific article published on 01 November 1998

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

scientific article

Rapid and sensitive detection of internal tandem duplication and activating loop mutations of FLT3.

scientific article published in July 2005

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

scientific article published on 16 August 2005

Reported cryptic rearrangements of CBFbeta-MYH11 in acute myeloid leukaemia are not due to false priming of contaminating DNA

scientific article published on 01 May 2000

Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.

scientific article published on 11 May 2015

Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibit

scientific article published in October 2002

TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis

scientific article published on 3 July 2008

Thalassaemia intermedia: interaction of the triple alpha-globin gene arrangement and heterozygous beta-thalassaemia

scientific article published on 01 May 1987

The activating splice mutation in intron 3 of the thrombopoietin gene is not found in patients with non‐familial essential thrombocythaemia ⬇️

scientific article published on 01 September 1998

The beta subunit common to the GM-CSF, IL-3 and IL-5 receptors is highly polymorphic but pathogenic point mutations in patients with acute myeloid leukaemia (AML) are rare.

scientific article

The clinical impact of mutant DNMT3A R882 variant allele frequency in acute myeloid leukaemia

scientific article published on 31 January 2020

The expression of prion protein (PrP(C)) in the megakaryocyte lineage.

scientific article

The expression of prion protein by endothelial cells: a source of the plasma form of prion protein?

scientific article published in December 2002

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

scientific article

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: ...

scientific article from 2010

The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia

scientific article published on 20 June 2013

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

scientific article

The production of JAK2 wild-type platelets is not downregulated in patients with JAK2 V617F mutant-positive essential thrombocythaemia

scientific article published on 12 January 2009

The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status

scientific article published on 22 July 2010

The prognostic significance of IDH2 mutations in AML depends on the location of the mutation

scientific article

The replication rate of human hematopoietic stem cells in vivo ⬇️

scientific article published on February 22, 2011

The retinoblastoma gene (rb1) in acute myeloid leukaemia: analysis of gene rearrangements, protein expression and comparison of disease outcome

scientific article

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.

scientific article published on 20 March 2018

The use of monoclonal antibodies UCH beta and UCH gamma for the antenatal diagnosis of beta-thalassaemia

scientific article published on 01 February 1987

The value of molecular stratification for CEBPA(DM) and NPM1(MUT) FLT3(WT) genotypes in older patients with acute myeloid leukaemia

scientific article published on 21 December 2015

Tissue specificity of X-chromosome inactivation patterns

scientific article published on 01 May 1994

Transcription-mediated amplification and hybridisation protection assay to determine BCR-ABL transcript levels in patients with chronic myeloid leukaemia

scientific article published in March 2002

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia

scientific article published on 27 June 2006

Variable expression of p16 protein in patients with acute myeloid leukemia without gross rearrangements at the DNA level.

scientific article

Variable outcome and methylation status according to CEBPA mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment

scientific article

WT1 mutations in T-ALL

scientific article published on 03 June 2009

X chromosome inactivation analysis reveals a difference in the biology of ET patients with JAK2 and CALR mutations

scientific article published on 19 August 2014

X-chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post-chemotherapy females.

scientific article

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