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List of works by Aubin Moutal

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

scientific article published on 7 April 2015

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

scientific article published on 09 March 2016

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

scientific article published on 6 September 2018

A light-gated potassium channel for sustained neuronal inhibition

scientific article published on 30 October 2018

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

scientific article published on July 2015

A porcine model of neurofibromatosis type 1 that mimics the human disease

scientific article published on 21 June 2018

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

scientific article

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons

scientific article published on 01 December 2019

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1

scientific article published on 01 November 2019

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

scientific article published on 01 January 2019

Blocking CRMP2 SUMOylation reverses neuropathic pain

scholarly article by Aubin Moutal published in November 2018

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

scientific article published on 3 July 2017

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.

scientific article published on 28 June 2017

CRMP2 is necessary for Neurofibromatosis type 1 related pain.

scientific article published on 24 August 2017

CRMP2-Neurofibromin Interface Drives NF1-related Pain

scientific article published on 12 April 2018

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.

scientific article

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

scientific article published on 26 July 2018

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

scientific article published on 01 December 2021

Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant

scientific article published on 15 July 2019

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

scientific article

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

scientific article published on 31 July 2017

Druggability of CRMP2 for neurodegenerative diseases

scientific article published on 21 July 2020

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

scientific article published on 27 March 2019

Efficacy of (S)-Lacosamide in preclinical models of cephalic pain

scientific article published on June 2016

Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief

scientific article published on 01 December 2019

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

scientific article

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

scientific article published on 08 December 2016

High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons

scientific article published on 27 September 2018

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

scientific article published on 5 February 2017

In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein

scientific article published on 23 September 2020

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

scientific article published on 01 October 2018

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

scientific article published in February 2017

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission

scientific article published on 18 December 2018

Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.

scientific article published on 10 April 2018

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

scientific article published on 24 August 2020

Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.

scientific article published on 11 May 2016

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

scientific article published on 11 June 2020

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

scientific article published on September 2016

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

scientific article published on 03 July 2020

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

scientific article published on 01 July 2020

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

scientific article

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

scientific article published on 01 July 2019

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

scientific article

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

scientific article published on 01 February 2020

Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.

scientific article

Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?

scientific article published in April 2018

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