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List of works by Yutaka Fujiwara

A novel serum metabolomics-based diagnostic approach to pancreatic cancer.

scientific article

A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors

scientific article published on 22 April 2014

A phase 1 study evaluating the pharmacokinetics and preliminary efficacy of veliparib (ABT-888) in combination with carboplatin/paclitaxel in Japanese subjects with non-small cell lung cancer (NSCLC).

scientific article

A phase I study of resminostat in Japanese patients with advanced solid tumors

scientific article

Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma.

scientific article published on 29 June 2017

Adjuvant chemotherapy in patients with completely resected small cell lung cancer: a retrospective analysis of 26 consecutive cases.

scientific article published on 5 August 2014

Appearance of a BRAF Mutation Conferring Resistance to Crizotinib in Non-Small Cell Lung Cancer Harboring Oncogenic ROS1 Fusion.

scientific article published in April 2018

Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab

article

Candidates for Intensive Local Treatment in cIIIA-N2 Non-Small Cell Lung Cancer: Deciphering the Heterogeneity.

scientific article published on 26 September 2015

Change in the lymphocyte-to-monocyte ratio is an early surrogate marker of the efficacy of nivolumab monotherapy in advanced non-small-cell lung cancer

scientific article published on 13 August 2018

Clinicopathological features in young patients treated for small-cell lung cancer: significance of immunohistological and molecular analyses

scientific article published on 14 December 2013

Comparison of Amrubicin and Weekly Cisplatin/Etoposide/Irinotecan in Patients With Relapsed Small-cell Lung Cancer.

scientific article published on 25 October 2016

Comparison of Radiotherapy and Chemoradiotherapy for Locoregional Recurrence of Non-small-cell Lung Cancer Developing After Surgery.

scientific article published on 10 May 2017

Comparison of the pharmacokinetics of erlotinib administered in complete fasting and 2 h after a meal in patients with lung cancer.

scientific article published on 21 May 2015

Current Status of Single-Agent Phase I Trials in Japan: Toward Globalization.

scientific article published on 27 April 2015

Cytotoxic chemotherapy may overcome the development of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) therapy

scientific article published on 2 July 2015

Do all patients in the phase I oncology trials need to be hospitalized? Domestic but outstanding issues for globalization of drug development in Japan

scientific article

Effect of sequential chemoradiotherapy in patients with limited-disease small-cell lung cancer who were ineligible for concurrent therapy: a retrospective study at two institutions

scientific article

Effects of aprepitant on the pharmacokinetics of controlled-release oral oxycodone in cancer patients

scientific article

Efficacy and safety of osimertinib in a Japanese compassionate use program.

scientific article published on 13 April 2017

Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.

scientific article published on 21 April 2016

Epidermal growth factor receptor mutation is associated with longer local control after definitive chemoradiotherapy in patients with stage III nonsquamous non-small-cell lung cancer.

scientific article published on 13 October 2014

Evaluation of time to failure of strategy as an alternative surrogate endpoint in patients with lung cancer with EGFR mutations

scientific article published on 28 November 2018

Expression of programmed death 1 (PD-1) and its ligand (PD-L1) in thymic epithelial tumors: Impact on treatment efficacy and alteration in expression after chemotherapy.

scientific article published on 12 May 2016

Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study

article

First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors

scientific article published on 24 January 2019

First-in-human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors

scientific article published on 01 February 2020

Five-year safety and efficacy data from a phase Ib study of nivolumab and chemotherapy in advanced non-small-cell lung cancer

scientific article published on 11 April 2020

Global trends in the distribution of cancer types among patients in oncology phase I trials, 1991-2015

scientific article published on 07 August 2018

High sensitivity detection of epidermal growth factor receptor mutations in the pleural effusion of non-small cell lung cancer patients

scientific article published on 01 July 2006

Hypothyroidism in patients with colorectal carcinoma treated with fluoropyrimidines.

scientific article published on 30 July 2013

Impact of KRAS mutation on response and outcome of patients with stage III non-squamous non-small cell lung cancer

scientific article

Individual optimal dose of amrubicin to prevent severe neutropenia in Japanese patients with lung cancer

scientific article published on 03 October 2019

Infection risk with PI3K-AKT-mTOR pathway inhibitors and immune checkpoint inhibitors in patients with advanced solid tumours in phase I clinical trials

scientific article published on 01 April 2020

Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification

scientific article published on 17 May 2012

Instrumental evaluation sensitively detects subclinical skin changes by the epidermal growth factor receptor inhibitors and risk factors for severe acneiform eruption

scientific article published on 07 November 2018

Left atrial extension of metastatic lung tumor via pulmonary vein: report on the first case of Ewing sarcoma.

scientific article published on 30 September 2010

Lenvatinib in combination with everolimus in patients with advanced or metastatic renal cell carcinoma: A phase 1 study

scientific article published on 20 August 2018

Long-term survival without surgery in NSCLC patients with synchronous brain oligometastasis: systemic chemotherapy revisited.

scientific article published in March 2018

Malignant pleural effusion as a predictor of the efficacy of anti-PD-1 antibody in patients with non-small cell lung cancer

scientific article published on 14 February 2019

Management of axitinib (AG-013736)-induced fatigue and thyroid dysfunction, and predictive biomarkers of axitinib exposure: results from phase I studies in Japanese patients.

scientific article

Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line.

scientific article

Medical treatment involving investigational drugs and genetic profile of thymic carcinoma.

scientific article

Metabolomics evaluation of serum markers for cachexia and their intra-day variation in patients with advanced pancreatic cancer

scientific article

Mixed response to osimertinib and the beneficial effects of additional local therapy

scientific article published on 08 February 2019

PD-L1 expression in neuroendocrine tumors of the lung.

scientific article published on 24 March 2017

Pharmacokinetic Study of Adjuvant Gemcitabine Therapy for Biliary Tract Cancer following Major Hepatectomy (KHBO1101).

scientific article

Pharmacokinetic profiles of significant adverse events with crizotinib in Japanese patients with ABCB1 polymorphism

scientific article published on 06 June 2016

Pharmacokinetic study of the oral fluorouracil antitumor agent S-1 in patients with impaired renal function.

scientific article published on 11 May 2019

Phase 1 Study of Cabozantinib in Japanese Patients With Expansion Cohorts in Non-Small-Cell Lung Cancer

scientific article published on 31 December 2018

Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer.

scientific article published on 16 June 2016

Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors.

scientific article

Phase 1 study of the investigational, oral angiogenesis inhibitor motesanib in Japanese patients with advanced solid tumors.

scientific article published on 28 January 2010

Phase 1/2 study assessing the safety and efficacy of dabrafenib and trametinib combination therapy in Japanese patients with BRAF V600 mutation-positive advanced cutaneous melanoma.

scientific article

Phase I and pharmacokinetic study of vorinostat (suberoylanilide hydroxamic acid) in Japanese patients with solid tumors.

scientific article

Phase I and pharmacokinetics/pharmacodynamics study of the MEK inhibitor RO4987655 in Japanese patients with advanced solid tumors.

scientific article published on 27 March 2015

Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors

scientific article published on 27 June 2007

Phase I dose-escalation study and biomarker analysis of E7080 in patients with advanced solid tumors.

scientific article

Phase I dose-finding study of monotherapy with atezolizumab, an engineered immunoglobulin monoclonal antibody targeting PD-L1, in Japanese patients with advanced solid tumors

scientific article published on July 2016

Phase I study of ipilimumab in phased combination with paclitaxel and carboplatin in Japanese patients with non-small-cell lung cancer.

scientific article published in May 2015

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with advanced solid tumors

scientific article

Phase I, dose escalation and pharmacokinetic study of cediranib (RECENTIN), a highly potent and selective VEGFR signaling inhibitor, in Japanese patients with advanced solid tumors.

scientific article

Phase I, multicenter, open-label, dose-escalation study of sonidegib in Asian patients with advanced solid tumors

scientific article published on 28 July 2016

Phase II study of amrubicin at a dose of 45 mg/m2 in patients with previously treated small-cell lung cancer.

scientific article

Phase II study of nab-paclitaxel + carboplatin for patients with non-small-cell lung cancer and interstitial lung disease

scientific article published on 06 November 2019

Phase II trial of S-1 treatment as palliative-intent chemotherapy for previously treated advanced thymic carcinoma

scientific article published on 19 August 2020

Phase Ia/Ib study of the pan-class I PI3K inhibitor pictilisib (GDC-0941) administered as a single agent in Japanese patients with solid tumors and in combination in Japanese patients with non-squamous non-small cell lung cancer.

scientific article published on 27 August 2016

Picoliter-Droplet Digital Polymerase Chain Reaction-Based Analysis of Cell-Free Plasma DNA to Assess EGFR Mutations in Lung Adenocarcinoma That Confer Resistance to Tyrosine-Kinase Inhibitors

scientific article published on 14 January 2016

Radiographic features and poor prognostic factors of interstitial lung disease with nivolumab for non-small cell lung cancer

scientific article published on 24 October 2020

Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer

scientific article published on 15 March 2016

Rapid improvement of glucagonoma-related necrolytic migratory erythema with octreotide

scientific article published on 9 April 2014

Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells

scientific article

Reliability of Small Biopsy Samples Compared With Resected Specimens for the Determination of Programmed Death-Ligand 1 Expression in Non--Small-Cell Lung Cancer.

scientific article published on 4 April 2015

Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma.

scientific article published on 18 December 2015

Safety and efficacy of nivolumab and standard chemotherapy drug combination in patients with advanced non-small-cell lung cancer: a four arms phase Ib study.

scientific article published on 20 October 2016

Safety and pharmacokinetics of DS-6051b in Japanese patients with non-small cell lung cancer harboring ROS1 fusions: a phase I study.

scientific article

Safety, tolerability, and pharmacokinetic profile of dabrafenib in Japanese patients with BRAF (V600) mutation-positive solid tumors: a phase 1 study.

scientific article published on 7 September 2017

Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer

scientific article published on 13 December 2013

Sequential Use of Anaplastic Lymphoma Kinase Inhibitors in Japanese Patients With ALK-Rearranged Non-Small-Cell Lung Cancer: A Retrospective Analysis

scientific article published on 7 December 2016

Serum total bilirubin as a predictive factor for severe neutropenia in lung cancer patients treated with cisplatin and irinotecan

scientific article published on 30 May 2007

Successful EGFR-TKI Rechallenge of Leptomeningeal Carcinomatosis after Gefitinib-induced Interstitial Lung Disease ⬇️

scientific article published on February 13, 2013

Surveillance of protocol deviations in Japanese oncology registration trials: a single institute experience

scientific article published on February 2017

The first case of SMARCB1 (INI1) - deficient squamous cell carcinoma of the pleura: a case report

scientific article published on 7 April 2018

The genomic and epigenomic landscape in thymic carcinoma

scientific article published on 01 October 2017

Tolerability and efficacy of durvalumab in Japanese patients with advanced solid tumors

scientific article published on 13 April 2019

Treatment and relapse of interstitial lung disease in nivolumab-treated patients with non-small cell lung cancer

scientific article published on 30 October 2020

Tremelimumab-associated tumor regression following after initial progression: two case reports

scientific article published on 02 October 2015

Validity of new methods to evaluate renal function in cancer patients treated with cisplatin

scientific article published on 20 January 2016

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