List of works by Luis de Lecea

A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition

scientific article

A cortical neuropeptide with neuronal depressant and sleep-modulating properties

scientific journal article

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

scientific journal article

A role for Melanin-Concentrating Hormone in learning and memory.

scientific article

Activation of central orexin/hypocretin neurons by dietary amino acids

scientific article published on 01 November 2011

Addiction and arousal: alternative roles of hypothalamic peptides.

scientific article published on October 2006

Addiction and arousal: the hypocretin connection.

scientific article

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses.

scientific article

Arousal State-Dependent Alterations in VTA-GABAergic Neuronal Activity

scientific article published on 30 March 2020

Basal forebrain cholinergic modulation of sleep transitions

scientific article

Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain.

scientific article published in March 1996

Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens

scientific article

Cortistatin as a therapeutic target in inflammation.

scientific article published on January 2007

Cortistatin attenuates inflammatory pain via spinal and peripheral actions.

scientific article

Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.

scientific article published on 17 April 2013

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

scientific article published on 4 October 2011

Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning.

scientific article published on 22 September 2005

Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain.

scientific article published in January 2005

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions

scientific article published on 01 September 2000

Effect of cortistatin on tau phosphorylation at Ser262 site.

scientific article published in August 2008

Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain

scientific journal article

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

scientific article published on 9 June 2016

Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.

scientific article published on 15 June 2016

Hyperexcitable arousal circuits drive sleep instability during aging

scientific article published on 25 February 2022

Hypocretin (orexin) neuromodulation of stress and reward pathways.

scientific article

Hypocretin (orexin) regulation of sleep-to-wake transitions

scientific article published on 12 February 2014

Hypocretin as a Hub for Arousal and Motivation.

scientific article

Hypocretin/orexin deficiency decreases cocaine abuse liability

scientific article published on 15 February 2018

Hypocretins and Arousal

scientific article published on 24 December 2016

Hypocretins in the control of sleep and wakefulness.

scientific article published on May 2010

Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders

scientific article

Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability.

scientific article

Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression

scientific article published on 09 September 2020

Immunohistochemical localization and biochemical characterization of hypocretin/orexin-related peptides in the central nervous system of the frog Rana ridibunda.

scientific article published in January 2001

In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model.

scientific article

In vivo cell type-specific CRISPR gene editing for sleep research

scientific article published on 12 November 2018

In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

scientific article published in Nature Communications

Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake.

scientific article published in June 2005

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

scientific article published on 01 December 2004

Intraventricular administration of neuropeptide S has reward-like effects.

scientific article

Isolation and sequencing of a cDNA encoding the B isozyme of rat phosphoglycerate mutase.

scientific article

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.

scientific article published on 8 March 2016

Late appearance of parvalbumin-immunoreactive neurons in the rodent cerebral cortex does not follow an 'inside-out' sequence.

scientific article published in August 1992

Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior

scientific article

Light and chemical control of neuronal circuits: possible applications in neurotherapy.

scientific article published on 13 August 2014

Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems.

scientific article

Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures

scientific article published on 01 September 2000

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

scientific article (publication date: 15 November 2007)

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

scientific article published on 5 December 2017

Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states

scientific article published on 3 March 2017

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system ⬇️

scientific article published on October 25, 2010

Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice

scientific article

Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea.

scientific article published on 21 April 2010

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels

scientific article published in April 2015

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin

scientific article

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

scientific article

Optical probing of orexin/hypocretin receptor antagonists

scientific article published on 01 October 2018

Optogenetic Investigation of Arousal Circuits

scientific article published on 15 August 2017

Optogenetic control of hypocretin (orexin) neurons and arousal circuits

scientific article

Optogenetic deconstruction of sleep-wake circuitry in the brain

scientific article

Optogenetic disruption of sleep continuity impairs memory consolidation

scientific article

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

scientific article

Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice.

scientific article

Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction

scientific article

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

scientific article published on 23 July 2018

Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse.

scientific article published in August 2001

Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning

scientific article (publication date: 22 May 2009)

Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea.

scientific article published in September 2011

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease

scientific article

Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts.

scientific article

Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation

scientific article published on 06 September 2018

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

scientific journal article

Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice

scientific article published on 14 January 2013

Resting easy with a sleep regulator.

scientific article

Shining light on wakefulness and arousal.

scientific article published on 20 March 2012

Sleep and metabolism: role of hypothalamic neuronal circuitry

scientific article published on October 2010

Sleep and neuropsychiatric illness

scientific article published on 05 September 2019

Sleep and the hypothalamus

scientific article published on 26 October 2023

Sleep disruption impairs haematopoietic stem cell transplantation in mice

scientific article published on 14 October 2015

Sleep to forget: interference of fear memories during sleep

scientific article published on October 2013

Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.

scientific article published in April 2008

Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry.

scientific article

Structural and compositional determinants of cortistatin activity

article

Superficial Layer-Specific Histaminergic Modulation of Medial Entorhinal Cortex Required for Spatial Learning.

scientific article published on 16 January 2015

The brain hypocretins and their receptors: mediators of allostatic arousal.

scientific article published on February 2009

The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction.

scientific article

The development of parvalbumin-immunoreactivity in the neocortex of the mouse.

scientific article published in September 1994

The hypocretin/orexin system: an increasingly important role in neuropsychiatry.

scientific article

The hypocretins and their role in narcolepsy.

scientific article published on August 2009

The hypocretins as sensors for metabolism and arousal.

scientific article published on December 2008

The hypocretins/orexins: integrators of multiple physiological functions

scientific article

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

scientific article published in January 1998

The role of hypocretin in driving arousal and goal-oriented behaviors.

scientific article published on 27 November 2009

To sleep or not to sleep: neuronal and ecological insights.

scientific article

Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity

scientific article published on 01 September 1994

Transient colocalization of parvalbumin and calbindin D28k in the postnatal cerebral cortex: evidence for a phenotypic shift in developing nonpyramidal neurons.

scientific article published in July 1996

Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain ⬇️

scientific article published on April 15, 1993

Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons

scientific journal article

VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors

scientific article

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