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List of works by Toby J Phesse

Cited1 deficiency suppresses intestinal tumorigenesis.

scientific article

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-"

article

Deficiency of Mbd2 attenuates Wnt signaling

scientific journal article

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

scientific article published on 23 August 2017

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

scientific article published on 16 March 2016

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

scientific article published on 28 February 2014

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

scientific article published on August 2010

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations

scientific article published on 08 January 2019

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells

scientific article

Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer

scientific article

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.

scientific article published on 21 June 2019

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

scientific article published on 26 March 2018

Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.

scientific article published on 5 October 2016

Lgr5 joins the club of gastric stem cell markers in the corpus

scientific article published in June 2017

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

scientific article published on 5 March 2009

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

scientific article published on 09 June 2017

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

scientific article published on 30 March 2018

Myc deletion rescues Apc deficiency in the small intestine

scientific journal article

Normal stem cells in cancer prone epithelial tissues.

scientific article published on 06 January 2009

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

scientific article

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

scientific article published on 30 September 2014

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.

scientific article

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

scientific article published on 8 May 2014

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

scientific article published on 5 September 2006

Responding to R-spondin: slit2 potentiates intestinal regeneration.

scientific article

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

scientific article published on 25 November 2013

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy

scientific article published on 21 December 2017

The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

scientific article published on 08 July 2019

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

scientific article published on 31 May 2020

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

scientific article

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

scientific article published on 12 August 2014

Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice

scientific article

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

scientific article published on June 2017

Wnt Signalling in Gastrointestinal Epithelial Stem Cells.

scientific article

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.

scientific article published on 30 May 2017

deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis

scientific article published on 23 November 2018

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

scientific article published in February 2009

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