List of works - Kevin Brindle

(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

scientific article

(E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent

scientific article (publication date: 2011)

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

scientific article published on 7 January 2016

<sup>18</sup>F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography

scientific article published on 09 December 2020

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate

scientific article published on 18 January 2016

A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13 C imaging

scientific article published on 15 March 2020

A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging

scientific article

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

scientific article

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy

scientific article

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

scientific article published on 19 February 2018

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

scientific article

Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

scientific article

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

scientific article

Assessing responses to cancer therapy using molecular imaging

scientific article published on 24 October 2006

Brain Tumor Imaging.

scientific article

Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

scientific article published on 06 October 2020

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors

scientific article

Clinical proton MR spectroscopy in central nervous system disorders

scientific article published in March 2014

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

scientific article

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

scientific article

Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy

scientific article

Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

scientific article published on 01 December 2018

Detection of colorectal dysplasia using fluorescently labelled lectins.

scientific article

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

scientific article

Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy

scientific article

Development of Timd2 as a reporter gene for MRI

scientific article published on 15 May 2015

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

scientific article

Dual-modality gene reporter for in vivo imaging

scientific article

Dynamic (1) H imaging of hyperpolarized [1-(13) C]lactate in vivo using a reverse INEPT experiment.

scientific article

Enhanced detection of circulating tumor DNA by fragment size analysis

scientific article published on 01 November 2018

Fragmentation patterns and personalized sequencing of cell-free DNA in urine and plasma of glioma patients

scientific article published on 22 July 2021

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized C-methylglyoxal

scientific article published on 21 December 2018

Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

scientific article

Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer

scientific article published on 31 July 2020

Hyperpolarized C MRI: Path to Clinical Translation in Oncology

scientific article published on 23 November 2018

Hyperpolarized C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses

scientific article published on 10 September 2018

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

scientific article

Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

scientific article

Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-<sup>13</sup>C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study

scientific article published in 2022

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

scientific article published on 3 December 2015

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

scientific article

Imaging and 'omic' methods for the molecular diagnosis of cancer

scientific article

Imaging biomarker roadmap for cancer studies ⬇️

scientific article

Imaging cell surface glycosylation in vivo using "double click" chemistry

scientific article published on 16 May 2013

Imaging tumor metabolism using positron emission tomography

scientific article

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

scientific article

Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate

scientific article

Increasing the sensitivity of hyperpolarized [15 N2 ]urea detection by serial transfer of polarization to spin-coupled protons

scientific article published on 10 March 2020

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

scientific article

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis

scientific article

Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI

scientific article published on 10 December 2019

Mitochondrial dysfunction in patients with primary congenital insulin resistance

scientific article

Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin

scientific article

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate

scientific article

Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate

scientific article published in March 2012

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons

scientific article

Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI

scientific article

Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

scientific article published on 8 January 2018

Techniques: Visualizing apoptosis using nuclear magnetic resonance

scientific article

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform

scientific article

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

scientific article published on 22 September 2014

What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism?

scientific article

ctDNA monitoring using patient-specific sequencing and integration of variant reads

scientific article published on 01 June 2020

p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels

scientific article

List of works by Kevin Brindle

(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

(E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

<sup>18</sup>F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate

A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13 C imaging

A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

Assessing responses to cancer therapy using molecular imaging

Brain Tumor Imaging.

Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors

Clinical proton MR spectroscopy in central nervous system disorders

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy

Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Detection of colorectal dysplasia using fluorescently labelled lectins.

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy

Development of Timd2 as a reporter gene for MRI

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

Dual-modality gene reporter for in vivo imaging

Dynamic (1) H imaging of hyperpolarized [1-(13) C]lactate in vivo using a reverse INEPT experiment.

Enhanced detection of circulating tumor DNA by fragment size analysis

Fragmentation patterns and personalized sequencing of cell-free DNA in urine and plasma of glioma patients

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized C-methylglyoxal

Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer

Hyperpolarized C MRI: Path to Clinical Translation in Oncology

Hyperpolarized C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-<sup>13</sup>C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Imaging and 'omic' methods for the molecular diagnosis of cancer

Imaging biomarker roadmap for cancer studies ⬇️

Imaging cell surface glycosylation in vivo using "double click" chemistry

Imaging tumor metabolism using positron emission tomography

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate

Increasing the sensitivity of hyperpolarized [15 N2 ]urea detection by serial transfer of polarization to spin-coupled protons

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis

Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI

Mitochondrial dysfunction in patients with primary congenital insulin resistance

Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate

Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons

Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI

Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

Techniques: Visualizing apoptosis using nuclear magnetic resonance

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism?

ctDNA monitoring using patient-specific sequencing and integration of variant reads

p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels