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List of works by Yi Zhang

A transcriptional roadmap for 2C-like-to-pluripotent state transition

scientific article published on 29 May 2020

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

scientific article published on 8 July 2012

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function

scientific article

Active DNA demethylation: many roads lead to Rome.

scientific article

Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells

scientific article published on 20 December 2019

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

scientific article

Base-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seq

scientific article (publication date: June 2016)

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter

scientific article

Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.

scientific article

Cell totipotency: molecular features, induction, and maintenance

scientific article published on June 2015

Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis

scientific article published on 04 March 2022

Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction

scientific article published on 13 September 2019

Chemical answers to epigenetic crosstalk.

scientific article published on June 2008

Cloning and characterization of extended hammerheads from a diverse set of caudate amphibians.

scientific article published on June 1996

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

scholarly article

Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability ⬇️

scientific article published on June 9, 2011

DNA methylation in mammals

scientific article

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

scientific article

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

scientific article published on 18 October 2021

Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?

scientific article

Developmental regulation of Suz 12 localization

scientific article published on 29 June 2005

Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

scientific article published on 05 April 2021

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

scientific article published on 30 March 2011

Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain.

scientific article published on 25 February 2003

Early embryos reprogram DNA methylation in two steps ⬇️

scientific article published on 01 May 2012

Enzymatic Analysis of Tet Proteins: Key Enzymes in the Metabolism of DNA Methylation ⬇️

scientific article published on January 1, 2012

Essential role of DOT1L in maintaining normal adult hematopoiesis.

scientific article published on 19 July 2011

Everything is E(Z): linking histone methylation to B cell development.

scientific article published in February 2003

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

scientific article

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

scientific article

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

scientific article

Genomic imprinting of Xist by maternal H3K27me3.

scientific article published in October 2017

Haploinsufficiency, but not defective paternal 5mC oxidation, accounts for the developmental defects of maternal Tet3 knockouts

scientific article

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

scientific article (publication date: 5 May 2006)

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.

scientific article published on 21 August 2012

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

scientific article

Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

scientific journal article

Histone demethylase JHDM2A is involved in male infertility and obesity

scientific article

Histone demethylation by a family of JmjC domain-containing proteins

scientific article

Identification and functional characterization of the p66/p68 components of the MeCP1 complex.

scientific article

Identification of motifs that are conserved in 12 Drosophila species and regulate midline glia vs. neuron expression

scientific article

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.

scientific article

In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function.

scientific article

Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice

scientific article

Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1

scientific article (publication date: 6 December 2002)

It takes a PHD to interpret histone methylation

scientific article published on 01 July 2006

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

scientific article

Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes.

scientific article published on 5 January 2010

JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.

scientific article published on 8 April 2010

JmjC-domain-containing proteins and histone demethylation

scientific article (publication date: September 2006)

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

scientific article

KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway

article published in the Proceedings of the National Academy of Sciences of the United States of America

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.

scientific article

Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming ⬇️

scientific article published on April 22, 2012

Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

scientific article published on 20 August 2006

Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development

scientific article published on 27 May 2019

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

scientific article

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

scientific article (publication date: September 1999)

MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.

scientific article published on October 2006

Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS.

scientific article

Maternal H3K27me3 controls DNA methylation-independent imprinting.

scientific article

Maternal H3K27me3-dependent autosomal and X chromosome imprinting

scientific article published on 08 June 2020

Maternal knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells

scientific article published on 21 November 2018

Mechanism and function of oxidative reversal of DNA and RNA methylation

scientific article

Mechanism of Polycomb group gene silencing.

scientific article published in January 2004

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

scientific article

Mechanisms of epigenetic memory and addiction

scientific article

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

scientific journal article

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

scientific article (publication date: 3 August 2001)

Minireview: role of protein methylation and demethylation in nuclear hormone signaling.

scientific article published on 30 April 2009

Molecular biology: no exception to reversibility.

scientific article published in October 2004

Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells

scientific article published on 17 June 2019

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription

scientific article

Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome.

scientific article

Newt satellite 2 transcripts self-cleave by using an extended hammerhead structure

scientific article published on December 1991

Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes.

scientific article

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

scientific article published on 15 March 2007

Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition

scientific article published on 02 February 2022

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

scientific article

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.

scientific article

Purification of histone demethylases from HeLa cells.

scientific article published on December 2006

Regulation of TET protein stability by calpains.

scientific article published on 9 January 2014

Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos ⬇️

scientific article published on September 22, 2011

Reversing DNA methylation: mechanisms, genomics, and biological functions

scientific article published on January 2014

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.

scientific article published on 24 May 2010

Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation

scientific article published on 26 October 2004

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

scientific article

Role of H3K27 methylation in the regulation of lncRNA expression ⬇️

scientific article published on August 3, 2010

Role of Tet1 in erasure of genomic imprinting

scientific journal article

Role of hPHF1 in H3K27 methylation and Hox gene silencing

scientific article

Role of histone H2A ubiquitination in Polycomb silencing

scientific article

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

scientific article (publication date: November 2002)

Role of histone H3 lysine 27 methylation in X inactivation

scientific article (publication date: 4 April 2003)

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

scientific article

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

scientific article

Simultaneous mapping of active DNA demethylation and sister chromatid exchange in single cells.

scientific article published on 30 March 2017

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

scientific article published on March 2017

Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications

scientific article published on 19 July 2018

Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression

scientific article (publication date: 2 May 2001)

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

scientific article

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

scientific article (publication date: 7 March 2003)

Substrate preferences of the EZH2 histone methyltransferase complex.

scientific article published on 23 January 2006

TET enzymes, TDG and the dynamics of DNA demethylation.

scientific article

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

scientific article

Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells.

scientific article published on August 2011

The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.

scientific article published in October 2004

The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1

scientific article

The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3

scientific article

The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.

scientific article published on 21 September 2017

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities

scientific article (publication date: 16 October 1998)

The diverse functions of Dot1 and H3K79 methylation.

scientific article published on July 2011

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

scientific article published on April 2004

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

scientific article

The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.

scientific article

The retinoblastoma binding protein RBP2 is an H3K4 demethylase

scientific article published on 22 February 2007

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

scientific article

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

scientific article published on 11 March 2007

Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidation.

scientific article

Transcriptional regulation by histone ubiquitination and deubiquitination.

scientific article

Tudor, MBT and chromo domains gauge the degree of lysine methylation

scientific article

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

scientific journal article

Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

scientific article published on 6 August 2002

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

scientific article published on September 2009

mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression

scientific article (publication date: August 2003)

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

scientific article published on January 2007

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