List of works - Douglas A. Lauffenburger

Building with a scaffold: emerging strategies for high- to low-level cellular modeling

scientific article

Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway

scientific article published on 27 January 2004

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway

scientific article published on March 1999

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling.

scientific article

A compendium of signals and responses triggered by prodeath and prosurvival cytokines

scientific article published on 18 July 2005

Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution

scientific article published on November 1, 1991

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.

scientific article published on 13 April 2016

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".

scientific article published on 5 August 2002

Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling

scientific article

Self-assembly of a beta-sheet protein governed by relief of electrostatic repulsion relative to van der Waals attraction.

scientific article published on January 2000

Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

scientific article published on September 2011

Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes

scientific article

Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli

scientific article

Growth factor-induced cell motility in tumor invasion

scientific article published on 01 January 2002

Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells

scientific article published on 24 June 2015

Physical and biochemical regulation of integrin release during rear detachment of migrating cells

scientific article published on April 1, 1998

Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions

scientific article

Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration

scientific article published on 01 May 1999

EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathway

scientific article published on March 1, 1998

Engineering epidermal growth factor for enhanced mitogenic potency

scientific article published on December 1996

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

scientific article

Comparing signaling networks between normal and transformed hepatocytes using discrete logical models

scientific article

The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface

scientific article published on 06 October 2004

Defining principles of combination drug mechanisms of action

scientific article published on December 18, 2012

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

scientific article published on 16 March 2016

A biological approach to computational models of proteomic networks

scientific article

2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen

scientific article

Overexpression of Cellular Src in Fibroblasts Enhances Endocytic Internalization of Epidermal Growth Factor Receptor

scientific article published on November 28, 1997

Spatial range of autocrine signaling: modeling and computational analysis

scientific article

Kinetic analysis of chemotactic peptide receptor modulation

scientific article published on January 1, 1982

ADAM8 as a drug target in pancreatic cancer.

scientific article

Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data

scientific article

Collecting and organizing systematic sets of protein data

scientific article

Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects

scientific article published on 01 March 2003

Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae

scientific article

Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner

scientific article published on August 1, 1998

Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions

scientific article published on July 2005

Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes

scientific article

Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence

scientific article published on 01 January 2002

Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data

scientific article published in January 2004

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

scientific article

Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination Therapy

scientific article published on 06 December 2013

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs

scientific article published on 22 March 2011

Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

scientific article

A mammalian functional-genetic approach to characterizing cancer therapeutics

scientific article published on December 26, 2010

Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence

scientific article

Integrin dynamics on the tail region of migrating fibroblasts

scientific article published on 01 May 1996

Interleukin-7 receptor signaling network: an integrated systems perspective

scientific article published on April 2008

Acidic Extracellular pH Promotes Activation of Integrin αvβ3

scientific article published on January 19, 2011

Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

scientific article published on January 25, 2016

List of works by Douglas A. Lauffenburger

Building with a scaffold: emerging strategies for high- to low-level cellular modeling

Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling.

A compendium of signals and responses triggered by prodeath and prosurvival cytokines

Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".

Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling

Self-assembly of a beta-sheet protein governed by relief of electrostatic repulsion relative to van der Waals attraction.

Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes

Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli

Growth factor-induced cell motility in tumor invasion

Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells

Physical and biochemical regulation of integrin release during rear detachment of migrating cells

Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions

Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration

EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathway

Engineering epidermal growth factor for enhanced mitogenic potency

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

Comparing signaling networks between normal and transformed hepatocytes using discrete logical models

The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface

Defining principles of combination drug mechanisms of action

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

A biological approach to computational models of proteomic networks

2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen

Overexpression of Cellular Src in Fibroblasts Enhances Endocytic Internalization of Epidermal Growth Factor Receptor

Spatial range of autocrine signaling: modeling and computational analysis

Kinetic analysis of chemotactic peptide receptor modulation

ADAM8 as a drug target in pancreatic cancer.

Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data

Collecting and organizing systematic sets of protein data

Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects

Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae

Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner

Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions

Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes

Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence

Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination Therapy

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs

Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

A mammalian functional-genetic approach to characterizing cancer therapeutics

Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence

Integrin dynamics on the tail region of migrating fibroblasts

Interleukin-7 receptor signaling network: an integrated systems perspective

Acidic Extracellular pH Promotes Activation of Integrin αvβ3

Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression