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List of works by Douglas A. Lauffenburger

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Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

scientific article (publication date: 6 February 1997)
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

scientific article (publication date: 18 July 2006)
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

scholarly article
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength

scientific article published on 01 August 1993
Physicochemical modelling of cell signalling pathways.

scientific article
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis

scientific article published in December 2005
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules

scientific article
Mathematical model for the effects of adhesion and mechanics on cell migration speed

scientific article published on July 1, 1991
Cell adhesion and motility depend on nanoscale RGD clustering.

scientific article published on 01 May 2000
Regulation of Cell Migration by the Calcium-dependent Protease Calpain

scientific article published on December 26, 1997
Cutting to the chase: calpain proteases in cell motility

scientific article published on 01 January 2002
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

scientific article
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

scientific article
Cancer systems biology: a network modeling perspective

scientific article
Computational modeling of the EGF-receptor system: a paradigm for systems biology

scientific article
Mechanotransduction through growth-factor shedding into the extracellular space

scientific article published on 21 April 2004
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

scientific article
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis

scientific article published on December 2008
Microfluidic shear devices for quantitative analysis of cell adhesion

scientific article
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

scientific article published on 01 January 2000
Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

scientific article
A Functional Role for Antibodies in Tuberculosis

scientific article published on 21 September 2016
Modeling a snap-action, variable-delay switch controlling extrinsic cell death

scientific article
Logic-based models for the analysis of cell signaling networks

scientific article published on April 2010
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

scientific article published on 24 October 2016
Polyfunctional responses by human T cells result from sequential release of cytokines

scientific article
Genital inflammation and the risk of HIV acquisition in women

scientific article
The response of human epithelial cells to TNF involves an inducible autocrine cascade

scientific article published on March 2006
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration

scientific article
Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

scientific article published on 23 April 2001
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells

scientific article published on 06 August 2013
Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions

scientific article published on 11 July 2008
Systems analysis of EGF receptor signaling dynamics with microwestern arrays

scientific article
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

scientific article published on May 1999
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

scientific article
Computational model for cell migration in three-dimensional matrices

scientific article
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus.

scientific article published on April 2002
Migration of individual microvessel endothelial cells: stochastic model and parameter measurement

scientific article published on June 1, 1991
CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms

scientific article
Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis

scientific article published on October 7, 1991
Common effector processing mediates cell-specific responses to stimuli

scientific article
Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

scientific article
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

scientific article
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels

scientific article published on 9 April 2003
Tumor invasion as dysregulated cell motility

scientific article
The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

scientific article published on June 15, 1991
Targeting tumor cell motility as a strategy against invasion and metastasis

scientific article published on 06 April 2013
A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations

scientific article published on 01 February 1988
A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates

scientific article
A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model

scientific article published in March 2001

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