List of works by Larry Sklar

A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux.

scientific article published in January 2016

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry

article

A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions

scientific article published on 22 June 2020

A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients

scientific article

A Pan-GTPase Inhibitor as a Molecular Probe

scientific article

A Potent and Selective Inhibitor of Cdc42 GTPase

A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling

scientific article published on 06 November 2019

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

scientific article

A crowdsourcing evaluation of the NIH chemical probes

scientific article (publication date: July 2009)

A high throughput flow cytometric assay platform targeting transporter inhibition

scientific article

A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants

scientific article

A miniature Couette to generate shear for flow cytometry: studying real-time modulation of intracellular calcium in monocytic cells

scientific article published on 10 February 2011

A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system

scientific article published on May 2008

A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6

scientific article

A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand

scientific article published on March 2009

A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging

scientific article published on 23 July 2011

A quantitative approach for studying IgE-FcepsilonRI aggregation

scientific article published on 01 September 2002

A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry

scientific article

A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

scientific article

ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle

retracted scientific article

Activation of Rho Family GTPases by Small Molecules.

scientific article

Advances in multiple analyte profiling.

scientific article

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article

Alpha4beta1 integrin affinity changes govern cell adhesion

scientific article published on 3 July 2003

An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicans virulence-related proteins

scientific article

An interview with Larry Sklar, Ph.D., and Bruce Edwards, Ph.D. Interview by Vicki Glaser

scientific article published in August 2010

An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system

scientific article

Arrestin Variants Display Differential Binding Characteristics for the PhosphorylatedN-Formyl Peptide Receptor Carboxyl Terminus

scientific article published in Journal of Biological Chemistry

Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion.

scientific article published on 2 August 2012

Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.

scientific article published on March 2011

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Badapple: promiscuity patterns from noisy evidence

scientific article

Biomimetic Molecular Assemblies on Glass and Mesoporous Silica Microbeads for Biotechnology†

Biomolecular recognition on well-characterized beads packed in microfluidic channels

scientific article published on 01 March 2002

Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform

Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization

scientific article

Chapter 11. Subsecond analyses of G-protein coupled-receptor ternary complex dynamics by rapid mix flow cytometry

scientific article published on January 2009

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

scientific article published on 4 February 2013

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

scientific article published in March 2014

Clioquinol: To harm or heal

scientific article published on 18 March 2019

Cluster cytometry for high-capacity bioanalysis.

scientific article published on 21 March 2012

Conformational mAb as a tool for integrin ligand discovery

scientific article

Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation

scientific article

Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia.

scientific article

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system

scientific article

Diazo coupling method for covalent attachment of proteins to solid substrates

scientific article

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

Discovery of regulators of receptor internalization with high-throughput flow cytometry

scientific article

Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30

scientific article

Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists

scientific article

Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships

scientific article

Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system

scientific article

Drug Repurposing from an Academic Perspective

scientific article published on January 2011

Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity

scientific article published on 07 February 2020

Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes

scientific article

Duplexed, bead-based competitive assay for inhibitors of protein kinases

scientific article

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

scientific article published on 01 February 2020

Dynamics of fluorescence dequenching of ostrich-quenched fluorescein biotin: a multifunctional quantitative assay for biotin

scientific article published in July 2005

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

scientific article published on July 2004

Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide

scientific article

Erratum: A crowdsourcing evaluation of the NIH chemical probes

article

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

scientific article published on January 2008

Evaluating integrin activation with time-resolved flow cytometry

scientific article published on 01 July 2018

FRET detection of cellular alpha4-integrin conformational activation.

scientific article

FRET detection of lymphocyte function-associated antigen-1 conformational extension.

scientific article

Far away from the lamppost

scientific article published on 11 December 2018

Flow Cytometry: Impact on Early Drug Discovery

scientific article

Flow cytometric analysis of ligand-receptor interactions and molecular assemblies

scientific article

Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis

scientific article

Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening

scientific article

Flow cytometry for high-throughput, high-content screening

scientific article

Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases

scientific article published on 08 July 2008

Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters

scientific article

Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia

scientific article

Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins

scientific article

GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone

scientific article published on 17 January 2011

GPR30: A G protein-coupled receptor for estrogen

scientific article

GPR30: a novel therapeutic target in estrogen-related disease

scientific article published on 11 February 2008

Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion

scientific article

Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.

scientific article published in May 2006

High throughput flow cytometry based yeast two-hybrid array approach for large-scale analysis of protein-protein interactions

scientific article published on 27 September 2011

High-Throughput Flow Cytometry

High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy Analysis Software, SynScreen

scientific article published on 29 May 2018

High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL

article

High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.

scientific article published in January 2018

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining

article published in 2018

High-content screening: flow cytometry analysis

scientific article

High-throughput cytotoxicity screening by propidium iodide staining

scientific article published on July 2007

High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors

scientific article published on January 2012

High-throughput flow cytometry compatible biosensor based on fluorogen activating protein technology

scientific article

High-throughput flow cytometry for drug discovery

scientific article published in May 2007

High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters

scientific article

High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening

scientific article

High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors

scientific article

High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry

scientific article

High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent

scientific article

High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands

scientific article

Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

scientific article

High‐throughput flow cytometry: Validation in microvolume bioassays ⬇️

scientific article published on May 1, 2003

Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p

scientific article published on 03 July 2009

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity

scientific article published on 14 July 2011

Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay

scientific article

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

scientific article published in February 2012

Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry

scientific article

Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening

scientific article (publication date: 2014)

Immobilized stromal cell-derived factor-1alpha triggers rapid VLA-4 affinity increases to stabilize lymphocyte tethers on VCAM-1 and subsequently initiate firm adhesion

scientific article

In vivo effects of a GPR30 antagonist

scientific article

Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents

scientific article

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

scientific article

Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins

scientific article published in February 2005

Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p).

scientific article

Integration of virtual and physical screening

Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists

scientific article published on 23 August 2005

Is prolonged stem cell mobilization detrimental for hematopoiesis?

scientific article

Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.

scientific article published in November 2003

Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates.

scientific article published on November 2006

Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide

scientific article published on April 2009

Microbial efflux pump inhibition: tactics and strategies

scientific article

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

scientific article published in May 2006

Microsphere‐Based Flow Cytometry Protease Assays for Use in Protease Activity Detection and High‐Throughput Screening ⬇️

scientific article published on October 1, 2010

N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity

scientific article published on 6 November 2002

Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

scientific article

Novel ABCG2 Antagonists Reverse Topotecan-Mediated Chemotherapeutic Resistance in Ovarian Carcinoma Xenografts

scientific article published on 26 September 2016

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

scientific article

Nozzle design parameters and their effects on rapid sample delivery in flow cytometry.

scientific article published in February 2002

Open, reconfigurable cytometric acquisition system: ORCAS.

scientific article

Overview: assays for studying integrin-dependent cell adhesion.

scientific article published on January 2012

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

scientific article

Pharos: Collating protein information to shed light on the druggable genome

scientific article

Post-high-throughput screening analysis: an empirical compound prioritization scheme

scientific article published in August 2005

Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.

scientific article published on 15 May 2008

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway

scientific article published on 10 May 2013

Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

scientific article published on 09 September 2020

Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein.

scientific article published in January 2015

Quantum Dots for Quantitative Flow Cytometry ⬇️

scientific article published on January 1, 2011

R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis

scientific article

Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides

scientific article published on 14 August 2007

Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation

scientific article

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

scientific article

Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.

scientific article

Real-time analysis of very late antigen-4 affinity modulation by shear

scientific article

Real-time detection of protein trafficking with high-throughput flow cytometry (HTFC) and fluorogen-activating protein (FAP) base biosensor

scientific article

Real-time partitioning of octadecyl rhodamine B into bead-supported lipid bilayer membranes revealing quantitative differences in saturable binding sites in DOPC and 1:1:1 DOPC/SM/cholesterol membranes

scientific article

Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: Toward the development of high-throughput screening flow cytometry assays

scientific article published on 2 April 2010

Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin

scientific article published on June 2007

Regulation of human basophil adhesion to endothelium under flow conditions: Different very late antigen 4 regulation on umbilical cord blood-derived and peripheral blood basophils.

scientific article published in September 2002

Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stress

scientific article

Relationship of light scatter change and Cdc42-regulated actin status.

scientific article published on 13 January 2015

Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

scientific article published in September 2003

Retraction Notice to: ATP Hydrolysis-Dependent Disassembly of the 26S Proteasome Is Part of the Catalytic Cycle

scientific article published on 01 April 2018

Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3.

scientific article published on 20 February 2006

Selective Bcl-2 Inhibitor Probes

scientific article published on 10 May 2013

Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2

scientific article published on 10 May 2013

Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries

scientific article

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance

scientific article (publication date: June 2014)

Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples.

scientific article

Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus

scientific article

Small-volume rapid-mix device for subsecond kinetic analysis in flow cytometry

scientific article published in September 2005

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads

scientific article published on January 2007

Spectroscopic characterization of streptavidin functionalized quantum dots

scientific article

Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands

scientific article published on July 2006

Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.

scientific article

Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.

scientific article published on 27 July 2007

TIN-X: target importance and novelty explorer

scientific article published on 07 April 2017

Targeting efflux pumps to overcome antifungal drug resistance

scientific article published on 27 July 2016

Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy

scientific article

Techniques: GPCR assembly, pharmacology and screening by flow cytometry.

scientific article

The University of New Mexico Center for Molecular Discovery

scientific article

The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy

scientific article

The evaluation of thioridazine as a hematopoietic progenitor cell mobilizing agent in healthy human subjects

scientific article published on 4 February 2015

The ins and outs of GPR30: a transmembrane estrogen receptor

scientific article published on 6 March 2008

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates

scientific article

The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures.

scientific article

Three small molecule pan activator families of Ras-related GTPases

Unexplored therapeutic opportunities in the human genome

scientific article published on 23 March 2018

Unexplored therapeutic opportunities in the human genome.

scientific article published on 23 February 2018

Virtual and <i>In Vitro</i> Antiviral Screening Revive Therapeutic Drugs for COVID-19

scientific article published on 14 October 2020

Virtual and biomolecular screening converge on a selective agonist for GPR30.

scientific article published on 5 March 2006

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