List of works - Danette Daniels

CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2

scientific article published on 16 November 2020

Development of a Dehalogenase-Based Protein Fusion Tag Capable of Rapid, Selective and Covalent Attachment to Customizable Ligands ⬇️

scientific article published on October 5, 2012

Discovering protein interactions and characterizing protein function using HaloTag technology

scientific article published on 12 July 2014

Discovery and resistance mechanism of a selective CDK12 degrader

scientific article published on 22 March 2021

Examining the complexity of human RNA polymerase complexes using HaloTag technology coupled to label free quantitative proteomics.

scientific article

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

scientific article

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds using HiBiT CRISPR Cell Lines

scientific article published on 09 November 2020

Isolation of Intracellular Protein – DNA Complexes Using HaloCHIP, an Antibody-Free Alternative to Chromatin Immunoprecipitation ⬇️

scientific article published on January 1, 2013

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

scientific article published on 28 December 2018

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

scientific article published on 29 January 2022

Monitoring and deciphering protein degradation pathways inside cells

scientific article published on 19 December 2018

Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action

scientific article published on 30 August 2018

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation

scientific article

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

scientific article

Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules

scientific article published in January 2017

Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3

scientific article published on 01 December 2020

The TIP60 Complex Is a Conserved Coactivator of HIF1A

scientific article published on 15 June 2016

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

scientific article published on 21 October 2021

List of works by Danette Daniels

CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2

Development of a Dehalogenase-Based Protein Fusion Tag Capable of Rapid, Selective and Covalent Attachment to Customizable Ligands ⬇️

Discovering protein interactions and characterizing protein function using HaloTag technology

Discovery and resistance mechanism of a selective CDK12 degrader

Examining the complexity of human RNA polymerase complexes using HaloTag technology coupled to label free quantitative proteomics.

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds using HiBiT CRISPR Cell Lines

Isolation of Intracellular Protein – DNA Complexes Using HaloCHIP, an Antibody-Free Alternative to Chromatin Immunoprecipitation ⬇️

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

Monitoring and deciphering protein degradation pathways inside cells

Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules

Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3

The TIP60 Complex Is a Conserved Coactivator of HIF1A

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity