List of works - Hilal Lashuel

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides

scientific article published on 27 October 2016

A century-old debate on protein aggregation and neurodegeneration enters the clinic

scientific article published on October 2006

A glimpse of a possible amyloidogenic intermediate of transthyretin

scientific article published on September 2000

A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization

scientific article

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

scientific article published in October 2009

A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations

scientific article

Abeta protofibrils possess a stable core structure resistant to hydrogen exchange

scientific article published in December 2003

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

scientific article

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

scientific article published in December 2017

Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies ⬇️

scientific article published on August 21, 2013

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

scientific article published on October 2002

Amyloid fibril formation by macrophage migration inhibitory factor

scientific article

Amyloid single-cell cytotoxicity assays by nanomotion detection

scientific article published on 21 August 2017

Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

scientific article published on August 2010

Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies

scientific article published on August 2009

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

scientific article

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

scientific article

Arab world needs its science diaspora

scientific article published in April 2011

Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

scientific article published on May 2006

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation

scientific article published in October 2007

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

scientific article

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

scientific article

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

scientific article

Chemical Synthesis and Expression of the HIV‐1 Rev Protein ⬇️

scientific article published on April 12, 2011

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

scientific article published on 14 February 2012

Comparative Characterization of a Wild Type and Transmembrane Domain-Deleted Fatty Acid Amide Hydrolase: Identification of the Transmembrane Domain as a Site for Oligomerization ⬇️

scientific article published on October 27, 1998

Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)

scientific article

Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ.

scientific article published on 21 June 2015

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

scientific article published on 22 November 2017

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

scientific article

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line ⬇️

scientific article published on September 1, 2003

Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity

scientific article published on November 12, 2012

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

scientific article published in January 2007

Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease

scientific article published on 21 January 2009

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

scientific article published on 4 August 2003

Dopamine Affects the Stability, Hydration, and Packing of Protofibrils and Fibrils of the Wild Type and Variants of α-Synuclein†

scholarly article by Cristian Follmer et al published January 2007 in Biochemistry

E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

scientific article published on 5 April 2009

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

scientific article

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

scientific article published on 13 March 2012

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

scientific article

Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches

scientific article published in January 2012

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

scientific article

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

scientific article published on 3 July 2015

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

scientific article published on 10 April 2017

Highly efficient and chemoselective peptide ubiquitylation

scientific article published in January 2009

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

scientific article published on September 2008

Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils

scientific article

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease

scientific article published in May 2003

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

scientific article

In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein

scientific article

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

scientific article published on 2 February 2016

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

scientific article published on 14 January 2015

Inhibiting transthyretin amyloid fibril formation via protein stabilization

scientific article published on December 1996

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation ⬇️

scientific article published on October 27, 1998

Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

scientific article

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

scientific article published on January 2004

Islam: governments need to reform education and build a scientific culture.

scientific article published in November 2006

Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors

scientific article

Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation

scientific journal article

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

scientific article

Membrane permeabilization: a common mechanism in protein-misfolding diseases

scientific article

Membrane scission driven by the PROPPIN Atg18.

scientific article published on 13 October 2017

Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons

scientific article published on 4 December 2015

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores

scientific article

Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel

scientific article

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

scientific article published on 23 March 2017

Neurodegenerative disease: amyloid pores from pathogenic mutations

scientific article

New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE

scientific article

Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation

scientific article published on 13 February 2013

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

scientific article

Oligomerization properties of GCN4 leucine zipper e and g position mutants ⬇️

scientific article published on October 1, 1997

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease

scientific article

One-pot total chemical synthesis of human α-synuclein

scientific article published in October 2013

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

scientific article

Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

scientific article

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo

scientific article

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein

scientific journal article

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

scientific article

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

scientific article

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

scientific article

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation

scientific article

Phosphorylation of synucleins by members of the Polo-like kinase family

scientific article

Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders

scientific article

Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction ⬇️

scientific article published on July 7, 2012

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

scientific article

Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models

scientific article published on 11 July 2017

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research

scientific article

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta

scientific article

Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science

scientific article

Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions

scientific article published in October 2004

Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons ⬇️

scientific article published on June 1, 2012

Recombinant Human Retinol-Binding Protein Refolding, Native Disulfide Formation, and Characterization ⬇️

scientific article published on October 1, 1998

Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease

scientific article published on August 2006

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

scientific article published on January 2010

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

scientific article published in January 2016

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations

scientific article published on 29 June 2016

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding

Stable α-Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones ⬇️

scientific article published on September 16, 2010

Structural differences of amyloid-β fibrils revealed by antibodies from phage display

scientific article published on 18 June 2015

Structural properties of pore-forming oligomers of alpha-synuclein

article by Hai-Young Kim et al published 2 December 2009 in Journal of the American Chemical Society

Structure and function of the molecular chaperone Hsp104 from yeast

scientific article published on March 2010

Switch peptide via Staudinger reaction

scientific article published on 30 October 2008

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

scientific article

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents

scientific article

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

scientific article published in January 2002

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

scientific article published on 16 September 2013

The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden

scientific article published in March 2003

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

scientific article

The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor

scientific article

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

scientific article

The many faces of α-synuclein: from structure and toxicity to therapeutic target ⬇️

scientific article published on January 1, 2013

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions

scientific article published on October 1999

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

scientific article

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation

scientific article published on 16 August 2012

Transthyretin Quaternary and Tertiary Structural Changes Facilitate Misassembly into Amyloid ⬇️

scientific article published on January 1, 1997

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

scientific article

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

scientific article

List of works by Hilal Lashuel

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides

A century-old debate on protein aggregation and neurodegeneration enters the clinic

A glimpse of a possible amyloidogenic intermediate of transthyretin

A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations

Abeta protofibrils possess a stable core structure resistant to hydrogen exchange

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies ⬇️

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

Amyloid fibril formation by macrophage migration inhibitory factor

Amyloid single-cell cytotoxicity assays by nanomotion detection

Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

Arab world needs its science diaspora

Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

Chemical Synthesis and Expression of the HIV‐1 Rev Protein ⬇️

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Comparative Characterization of a Wild Type and Transmembrane Domain-Deleted Fatty Acid Amide Hydrolase: Identification of the Transmembrane Domain as a Site for Oligomerization ⬇️

Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)

Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line ⬇️

Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

Dopamine Affects the Stability, Hydration, and Packing of Protofibrils and Fibrils of the Wild Type and Variants of α-Synuclein†

E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Highly efficient and chemoselective peptide ubiquitylation

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

Inhibiting transthyretin amyloid fibril formation via protein stabilization

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation ⬇️

Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

Islam: governments need to reform education and build a scientific culture.

Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors

Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Membrane permeabilization: a common mechanism in protein-misfolding diseases

Membrane scission driven by the PROPPIN Atg18.

Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores

Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

Neurodegenerative disease: amyloid pores from pathogenic mutations

New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE

Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Oligomerization properties of GCN4 leucine zipper e and g position mutants ⬇️

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease

One-pot total chemical synthesis of human α-synuclein

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions