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List of works by Theodore Jardetzky

A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV

scientific article

A class act

scientific article published in Nature

A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion

scientific article

A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform

scientific article

A readily applicable strategy to convert peptides to peptoid-based therapeutics

scientific article

A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion

scientific article published on 29 November 2012

A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions.

scientific article

Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor

scientific article

Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

scientific article

Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail

scholarly article

Activation of paramyxovirus membrane fusion and virus entry

scientific article

An Engineered Disulfide Bond Reversibly Traps the IgE-Fc3-4 in a Closed, Nonreceptor Binding Conformation

scientific article

Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis

scientific article

Assembly and architecture of the EBV B cell entry triggering complex

scientific article (publication date: August 2014)

Beta A versus beta B: is it merely a matter of expression?

scientific article published in October 2004

Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering

scientific article

Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.

scientific article

Characteristics of Epstein-Barr virus envelope protein gp42.

scientific article

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

scientific article

Class III viral membrane fusion proteins

scientific article

Class III viral membrane fusion proteins

scientific article published on 01 January 2011

Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes

scientific article published on 15 April 2009

Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function

scientific article published on 9 December 2015

Conformational Flexibility in Immunoglobulin E-Fc3–4 Revealed in Multiple Crystal Forms

scientific article

Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state

scientific article published on December 2004

Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha

scientific article published on 26 October 2021

Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex

scientific article

De novo protein design enables the precise induction of RSV-neutralizing antibodies

scientific article published on 01 May 2020

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

scientific article published on 01 December 2020

Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia

publication published on 12 November 2021

Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein

scientific article published on 2 July 2008

EBV gH/gL and KSHV gH/gL bind to different sites on EphA2 to trigger fusion

scientific article published on 26 August 2020

Editorial overview: Virus structure and functions

scientific article published in June 2017

Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor

scientific article published on 19 February 2019

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

scientific article published in January 2018

Ephrin receptor A4 (EphA4) is a new Kaposi's sarcoma-associated herpesvirus virus entry receptor

EphrinB2 clustering by Nipah virus G is required to activate and trap F intermediates at supported lipid bilayer-cell interfaces

scientific article

Epstein-Barr virus fusion with epithelial cells triggered by gB is restricted by a gL glycosylation site.

scientific article published on 27 September 2017

Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion

scientific article published on 03 August 2016

Functional Analysis of the Transmembrane Domain in Paramyxovirus F Protein-Mediated Membrane Fusion

scientific article (publication date: 13 February 2009)

Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion

scientific article published on 20 May 2009

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

scientific article

Fusing structure and function: a structural view of the herpesvirus entry machinery

scientific article published on 11 April 2011

Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering

scientific article

Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells

scientific article published on 22 January 2014

H-IPSE is a pathogen-secreted host nucleus infiltrating protein (infiltrin) expressed exclusively by the Schistosoma haematobium egg stage.

scientific article published on 18 September 2017

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission

article

HIV: conformational camouflage

scientific article published on 01 December 2002

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2

scientific article published on 03 September 2020

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

scientific article published on 09 July 2020

Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity

scientific article

IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis

scientific article published on 20 February 2019

IPSE, a parasite-derived, host immunomodulatory infiltrin protein, alleviates resiniferatoxin-induced bladder pain

scientific article published on 01 January 2020

IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways

scientific article published in Scientific Reports

IPSE, an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium, promotes proliferation of bladder cancer cells and angiogenesis

scientific article published on 22 October 2020

Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors

scientific article published on 22 April 2022

Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins

scientific article published on 22 June 2016

Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling

scientific article published on 20 January 2012

Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.

scientific article published on 22 September 2017

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition ⬇️

scientific article published on September 22, 2003

Investigation of the function of the putative self-association site of Epstein-Barr virus (EBV) glycoprotein 42 (gp42).

scientific article

Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL.

scientific article

Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays

scientific article

Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers

scientific article

Molecular biology of inhibin action

scientific article published in August 2004

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

scientific article published on 3 October 2017

Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane-Proximal Stalk Region Influences Stability, Receptor Binding, and Neuraminidase Activity

scientific article published on 22 June 2016

Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion

scientific article

Mutational analysis of the HLA class II interaction with Epstein-Barr virus glycoprotein 42.

scientific article

Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability

scientific article published on 02 October 2013

NMEGylation: a novel modification to enhance the bioavailability of therapeutic peptides

scientific article published on January 2011

On the stability of parainfluenza virus 5 F proteins

scientific article

Paramyxovirus membrane fusion: lessons from the F and HN atomic structures

scientific article

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist

scientific article (publication date: 2010)

Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711-718

scientific article published on 01 October 2018

Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.

scientific article published on January 2015

Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies

scientific article

Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting

scientific article

Program review. Challenges and opportunities for training the next generation of biophysicists: perspectives of the directors of the Molecular Biophysics Training Program at Northwestern University

scientific article published on April 2008

Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy

scientific article

Reversible inhibition of fusion activity of a paramyxovirus fusion protein by an engineered disulfide bond in the membrane-proximal external region

scientific article

SARS-CoV-2 Antibody Responses Correlate with Resolution of RNAemia But Are Short-Lived in Patients with Mild Illness

scientific article published on 17 August 2020

Selectivity in the post-translational, transglutaminase-dependent acylation of lysine residues.

scientific article

Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion

scientific article

Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus

scientific article

Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions

scientific article

Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.

scientific article published on 08 December 2016

Structural basis for a functional antagonist in the transforming growth factor beta superfamily

scientific article published on 26 September 2005

Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus

scientific article published on 30 January 2017

Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein

scientific article published on 17 October 2016

Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.

scientific article published on 19 May 2016

Structural basis of viral invasion: lessons from paramyxovirus F

scientific article

Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding

scientific article published on 01 June 2006

Structural insights into the interactions between human IgE and its high affinity receptor FcepsilonRI.

scientific article

Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose

scientific article

Structure and Mutagenesis of the Parainfluenza Virus 5 Hemagglutinin-Neuraminidase Stalk Domain Reveals a Four-Helix Bundle and the Role of the Stalk in Fusion Promotion

scientific article

Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form

scientific article published on 28 December 2015

Structure of Epstein-Barr Virus Glycoprotein 42 Suggests a Mechanism for Triggering Receptor-Activated Virus Entry

scientific article

Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B

scientific article

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-  binding

scientific article

Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1

scientific article

Structure of the Newcastle disease virus F protein in the post-fusion conformation

scientific article

Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk

scientific article

Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence

scientific article

Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein

scientific article

Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site

scientific article

Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain

scientific article

Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation

scientific article

Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein

scientific article

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions

scientific article (publication date: April 2003)

The COMPLEXity in herpesvirus entry

scientific article

The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment

scientific article

The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion

scientific article

The IgA receptor complex: a two-for-one deal

The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells

scientific article published on 3 January 2012

The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells

scientific article

The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion

scientific article published on 16 January 2013

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

scientific article published on 08 January 2020

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding

scientific article published on August 2006

The structural basis of herpesvirus entry

scientific article published on 21 October 2020

The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding

scientific article

The structures that underlie normal reproductive function

scientific article published on 30 November 2006

Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis.

scientific article published on 3 April 2018

Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry

scientific article published on 12 March 2015

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