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List of works by David Schaffer

A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes.

scientific article published on 22 December 2016

A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line.

scientific article published on 13 September 2017

A medium-throughput analysis of signaling pathways involved in early stages of stem cell reprogramming

scientific article published on 02 September 2014

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

scientific article

AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers

scientific article published on 31 December 2013

AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina

scientific article

Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells.

scientific article

Adeno-associated virus (AAV) vectors in cancer gene therapy.

scientific article

Advanced targeting strategies for murine retroviral and adeno-associated viral vectors.

scientific article

Advances in AAV vector development for gene therapy in the retina

scientific article published on January 2014

Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis

scientific article published on May 2015

Akt Increases Sox2 Expression in Adult Hippocampal Neural Progenitor Cells, but Increased Sox2 Does Not Promote Proliferation ⬇️

scientific article published on December 22, 2010

Antiviral RNAi: translating science towards therapeutic success

scientific article published on 09 August 2011

Apodization Specific Fitting for Improved Resolution, Charge Measurement, and Data Analysis Speed in Charge Detection Mass Spectrometry

scientific article published in 2022

Bidirectional regulation of mRNA translation in mammalian cells by using PUF domains.

scientific article published on 26 March 2014

Biogenic gas nanostructures as ultrasonic molecular reporters

scientific article

Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior

scientific article published in April 2007

Biophysical regulation of epigenetic state and cell reprogramming

scientific article

Biophysical regulation of stem cell behavior within the niche

scientific article published on 14 December 2012

Biophysics and dynamics of natural and engineered stem cell microenvironments ⬇️

scientific article published on January 1, 2010

Bringing next-generation therapeutics to the clinic through synthetic biology

scientific article published on 18 May 2012

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes

scientific article published on 08 September 2016

CRISPR-mediated Activation of Latent HIV-1 Expression

scientific article published on 26 November 2015

Challenging Regeneration to Transform Medicine

scientific article

Characterization of integrin engagement during defined human embryonic stem cell culture

scientific article

Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing

scientific article published in January 2017

Computational models of the Notch network elucidate mechanisms of context-dependent signaling

scientific article

Conjugation of proteins to polymer chains to create multivalent molecules

scientific article published in January 2014

DNA shuffling of adeno-associated virus yields functionally diverse viral progeny

scientific article

Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

scientific article

Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer

scientific article

Designing synthetic materials to control stem cell phenotype

scientific article

Development of quantitative PCR methods to analyse neural progenitor cell culture state

scientific article published in April 2006

Directed evolution of adeno-associated virus to an infectious respiratory virus

scientific article

Dynamics of Mechanosensitive Neural Stem Cell Differentiation.

scientific article

Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease

scientific article

Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform

scientific article

Engineered AAV vectors for improved central nervous system gene delivery

scientific article published on 3 December 2015

Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons

scientific article published on 5 May 2017

Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography

scientific article

Engineering adeno-associated viruses for clinical gene therapy

scientific article published on 20 May 2014

Engineering biomaterials for synthetic neural stem cell microenvironments

scientific article published on May 2008

Engineering strategies to emulate the stem cell niche

scientific article published on 29 December 2009

Engineering the surface properties of synthetic gene delivery vectors

scientific article

Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus

scientific article published on January 2014

Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus

scientific article published in August 2007

Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus

scientific article

Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.

scientific article published on 22 January 2015

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

scientific article

Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies

scientific article

Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture

scientific article

Exploring and Engineering Stem Cells and their Niches

scientific article

Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells

scientific article published on 6 December 2011

Gene Editing to Generate Versatile Human Pluripotent Stem Cell Reporter Lines for Analysis of Differentiation and Lineage Tracing

scientific article published on 13 November 2019

Genetic approaches to tissue engineering: breakout session summary

scientific article published on 01 June 2002

Genetic approaches to tissue repair

scientific article published on 01 June 2002

Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications

scientific article published on 16 September 2015

Genome-wide activation screens to increase adeno-associated virus production

scientific article published on 16 July 2021

HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites

scientific article published on 31 January 2012

High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform

scientific article published on 27 October 2016

High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates

scientific article published on 07 August 2020

High-throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate

scientific article published on 06 November 2018

High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture

scientific article published on 27 October 2018

High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells

scientific article

Imaging light responses of foveal ganglion cells in the living macaque eye.

scientific article

Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells

scientific article published in December 2007

In situ stem cell therapy: novel targets, familiar challenges

scientific article

In vivo genome editing improves motor function and extends survival in a mouse model of ALS.

scientific article published on 20 December 2017

Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous

scientific article published in 2009

Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities

scientific article published on 12 January 2016

Investigating the GRNN Oracle as a Method for Combining Multiple Predictive Models of Colon Cancer Recurrence from Gene Microarrays

article

In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.

scientific article published on 8 September 2017

Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells

scientific article published on June 2004

Library selection and directed evolution approaches to engineering targeted viral vectors

scientific article

Light-inducible activation of target mRNA translation in mammalian cells.

scientific article published in September 2013

Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

scientific article

Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis

scientific article

Microarraying for mechanosensivitity

scientific article published in September 2010

Microarraying the cellular microenvironment

scientific article published on 4 July 2006

Microelastic mapping of the rat dentate gyrus

scientific article

Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis

scientific article published on 12 December 2007

Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scattering

scientific article

Molecular engineering of viral gene delivery vehicles

scientific article

Molecular evolution of adeno-associated virus for enhanced glial gene delivery

scientific article published on 11 August 2009

Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency

scientific article published on 2 April 2008

Multivalent ligands control stem cell behaviour in vitro and in vivo

scientific article published on 20 October 2013

NanoLiterBioReactor: long-term mammalian cell culture at nanofabricated scale

scientific article

Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons

scientific article published on January 2008

Neurogenesis and neuroadaptation

scientific article published on January 2004

Newborn neuroblasts feel the field in the adult brain

scientific article published on 18 January 2013

Nox2 redox signaling maintains essential cell populations in the brain

scientific article

Optogenetic protein clustering and signaling activation in mammalian cells

scientific article

Optogenetic tools for cell biological applications

scientific article published in December 2017

Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues

scientific article published on January 2010

Progress and prospects for stem cell engineering

scientific article published on January 2011

Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo

scientific article

Quantitative analysis of signaling mechanisms controlling adult neural progenitor cell proliferation

scientific article published in January 2004

Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach

scientific article published on 18 March 2020

Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses

scientific article published on 2 September 2009

Response to "HIV Escape From RNAi Antivirals: Yet Another Houdini Action?".

scientific article published on 12 June 2012

Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells

scientific article published in November 2011

Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture

scientific article published on 19 September 2007

Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas

scientific article published in January 2018

Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectors

scientific article

Signal dynamics in Sonic hedgehog tissue patterning

scientific article

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

scientific article published in February 2002

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

scientific article

Spatial organization of cell-adhesive ligands for advanced cell culture.

scientific article

Substrate modulus directs neural stem cell behavior

scientific article

Surface creasing instability of soft polyacrylamide cell culture substrates

scientific article

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

scientific article published in May 2015

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

scientific article

Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors

scientific article published in April 2007

The AAV vector toolkit: poised at the clinical crossroads

scientific article published on 24 January 2012

The biology and engineering of stem-cell control

scientific article published in August 2004

The delivery challenge: fulfilling the promise of therapeutic genome editing

scientific article published on 29 June 2020

The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons

scientific article published on 27 October 2013

The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age

scientific article published on 16 September 2014

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

scientific article published on 17 June 2009

The sonic hedgehog signaling system as a bistable genetic switch

scientific article

Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture

scientific article

Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells

scientific article published in April 2010

Translational repression using BIV Tat peptide-TAR RNA interaction in mammalian cells

scientific article published on August 2013

Transposon-based mutagenesis generates diverse adeno-associated viral libraries with novel gene delivery properties

scientific article published in January 2008

Viral Vectors for Gene Therapy: Translational and Clinical Outlook

scientific article

Viral infection: A key host receptor for AAV.

scientific article published on February 2016

Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas

scientific article published on September 2016

X-space MPI: magnetic nanoparticles for safe medical imaging

scientific article published on July 2012

cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming

scientific article published on 10 February 2015

hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding

scientific article published on May 2013

hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.

scientific article published on 5 April 2018

β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells

scientific article published on 02 November 2020

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