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List of works by Stephen Helfand

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

scientific article published on 21 December 2016

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

scholarly article

Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction.

scientific article published in December 2005

Chromatin structure and transposable elements in organismal aging

scientific article published on 04 December 2013

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

scientific article published on 12 September 2016

Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila.

scientific article

Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies

scholarly article

Contribution of Retrotransposable Elements to Aging

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

scholarly article by Andreas L. Birkenfeld et al published October 2011 in Cell Metabolism

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

scientific article

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

scientific article published on November 2013

Dietary restriction: standing up for sirtuins

scientific article published on August 2010

Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster

scientific article

Erratum: corrigendum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans

scientific article published in Nature

Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling.

scholarly article

From genes to aging in Drosophila

scientific article

Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy

scientific article

Functional characterization of a Drosophila mitochondrial uncoupling protein

scientific article published in June 2004

Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster

scientific article

Genetics of aging in the fruit fly, Drosophila melanogaster

scientific article

Impact papers on aging in 2009.

scientific article

Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner

scientific article (publication date: September 2013)

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

scientific article

Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion

scientific article published on January 2014

Indy mutations and Drosophila longevity

scientific article published on 8 April 2013

Involvement of Drosophila uncoupling protein 5 in metabolism and aging

scientific article

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

scientific article published on 07 March 2019

Long-lived Indy and calorie restriction interact to extend life span.

scientific article published on 22 May 2009

Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage

scholarly article

Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.

scientific article published in November 2002

Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span

scientific article published in November 2005

New comparative genomics approach reveals a conserved health span signature across species ⬇️

scientific article published on June 1, 2011

RNA editing regulates transposon-mediated heterochromatic gene silencing

scientific article published on January 2013

Sir2 and longevity: the p53 connection

scientific article

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

scientific article

Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster

scientific article published on 29 January 2018

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

scientific article (publication date: 5 August 2004)

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

scientific article published in February 2005

The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates

scientific article

Transcriptional response to dietary restriction in Drosophila melanogaster.

scientific article

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span

scientific article

dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster

scientific article published on January 2009

takeout-dependent longevity is associated with altered Juvenile Hormone signaling.

scientific article

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