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List of works by John G Doench

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels

scientific article published on 13 June 2019

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

article

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

scientific article published on 01 November 2019

A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion

scientific article published on 14 December 2018

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

scientific article published on 08 April 2019

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

scientific article published on 9 September 2016

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017

A case of mistaken identity

scientific article published on 01 September 2018

A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition

scientific article published on 18 May 2022

A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing

scientific article published on 4 January 2018

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

scientific article published on 20 December 2019

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

scientific article published on 26 May 2020

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

scientific article published on 20 April 2015

Am I ready for CRISPR? A user's guide to genetic screens

scientific article published on 4 December 2017

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

scientific article published on 30 July 2018

Analysis of microRNA effector functions in vitro

scientific article published on October 2007

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 25 June 2020

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

scientific article published on 25 July 2019

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

scientific article published on 14 March 2022

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

scientific article published on 15 September 2016

CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.

scientific article

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

scientific article published on 06 October 2020

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

scientific article published on 29 November 2019

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

scientific article published on 15 April 2019

CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors

scientific article published on May 2017

CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

scientific article published on 01 July 2019

CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity

scientific article published on 19 July 2016

CRISPR/Cas9 gene editing special issue

scientific article

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 18 May 2020

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

scientific article published on 6 October 2021

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

scientific article published on 05 May 2022

Comparison of siRNA-induced off-target RNA and protein effects

scientific article published on 19 January 2007

Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

scientific article published on 01 November 2020

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

scientific article published on 31 October 2017

Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

scientific article published on 13 June 2017

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

scientific article

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

scientific article published on 17 February 2020

DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression

scientific article published on 18 May 2020

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

scientific article

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

scientific article published in Nature

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

scientific article published on August 2017

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

scientific article published on 01 June 2020

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

scientific article

Design and analysis of CRISPR-Cas experiments

scientific article published on 13 April 2020

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

scientific article published on 21 February 2019

Discovering metabolic disease gene interactions by correlated effects on cellular morphology

article

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

scientific article published on 20 January 2020

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

scientific article

Discovery of a proteinaceous cellular receptor for a norovirus

scientific article

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

scientific article published on 05 May 2021

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

scientific article

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

scientific article

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

scientific article

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

scientific article published on 09 May 2019

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

scientific article published on September 2016

Genetic screens and functional genomics using CRISPR/Cas9 technology

scientific article

Genetic screens in isogenic mammalian cell lines without single cell cloning

scientific article published on 06 February 2020

Genome-scale CRISPR-Cas9 knockout screening in human cells

scientific article (publication date: 3 January 2014)

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

scientific article published on 20 October 2020

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

scientific article published on 09 January 2020

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

scientific article published on 17 June 2020

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

scientific article published on 24 January 2020

HDAC5 controls MEF2C-driven sclerostin expression in osteocytes

scientific article

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published on 28 July 2016

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published in December 2017

IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

article

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

scientific article

Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

scientific article published on 01 September 2020

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

scientific article published on 19 July 2017

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

scientific article published in 2022

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency

scientific article published in July 2015

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

scientific article published on 26 November 2020

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

scientific article published on February 2017

Kinase requirements in human cells: I. Comparing kinase requirements across various cell types

scholarly article

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

scientific article published on 17 December 2018

MEN1 mutations mediate clinical resistance to menin inhibition

scientific article published on 15 March 2023

MYC Controls the Epstein-Barr Virus Lytic Switch

scientific article published on 03 April 2020

Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion ⬇️

scientific article published on May 2015

Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

scientific article published on 31 January 2020

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

scientific article published on 19 September 2019

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

scientific article published on 21 July 2015

Mutational processes shape the landscape of TP53 mutations in human cancer.

scientific article

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

scientific article published on 12 July 2017

Natural variation in arsenic toxicity is explained by differences in branched chain amino acid catabolism

article

Natural variation in arsenic toxicity is explained by differences in branched chain amino acid metabolism

article

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes

scientific article published on 01 July 2018

Optimization of AsCas12a for combinatorial genetic screens in human cells

scientific article published on 13 July 2020

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

scientific article published in Nature Communications

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

scientific article published on 18 January 2016

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

scientific article

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

scientific article

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

scientific article published on 28 June 2018

Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

scientific article published on 10 January 2018

Progression signature underlies clonal evolution and dissemination of multiple myeloma

scientific article published on 04 November 2020

RNA interference of Xenopus NMDAR NR1 in vitro and in vivo

scientific article

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

scientific article

Recapitulation of short RNA-directed translational gene silencing in vitro

article

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.

scientific article published on April 2012

SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas

scientific article published on June 2013

Specificity of microRNA target selection in translational repression

scientific article (publication date: March 2004)

Synergistic interactions with PI3K inhibition that induce apoptosis.

scientific article

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

scientific article

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

scientific article

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

scientific article published on 11 December 2019

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer

scientific article published on 05 June 2018

UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages

scientific article published on 01 January 2021

Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens.

scientific article published on 25 May 2018

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential

scientific article published on 11 July 2018

siRNAs can function as miRNAs

scientific article (publication date: 15 February 2003)

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